USE OF A KINASE INHIBITOR FOR THE TREATMENT OF PARTICULAR RESISTANT TUMORS

USE OF A KINASE INHIBITOR FOR THE TREATMENT OF PARTICULAR RESISTANT TUMORS

The invention provides low molecular weight compounds, namely 1H-thieno[2,3-c]pyrazoles, showing a high affinity for the ATP pocket of ABL tyrosine kinase. These compounds are thus ATP-competitive tyrosine kinase inhibitors displaying a significant inhibitory potency also, and in particular, towards...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: FANCELLI, DANIELE, SONCINI, CHIARA, RUSCONI, LUISA, ISACCHI, ANTONELLA, LUPI, ROSITA, MODUGNO, MICHELE, MOLL, JURGEN
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page
container_issue
container_start_page
container_title
container_volume
creator FANCELLI, DANIELE
SONCINI, CHIARA
RUSCONI, LUISA
ISACCHI, ANTONELLA
LUPI, ROSITA
MODUGNO, MICHELE
MOLL, JURGEN
description The invention provides low molecular weight compounds, namely 1H-thieno[2,3-c]pyrazoles, showing a high affinity for the ATP pocket of ABL tyrosine kinase. These compounds are thus ATP-competitive tyrosine kinase inhibitors displaying a significant inhibitory potency also, and in particular, towards BCR-ABL inhibitor-resistant T315I ABL mutants. The compounds of the invention find a useful application in the treatment of BCR-ABL inhibitor-resistant ABL-mediated diseases, such as Imatinib-resistant chronic myelogenous leukemia. Moreover, the invention provides a screening method for the identification of compounds capable of binding the ATP pocket of a kinase protein, in particular of the T315I mutant ABL kinase.
format Patent
fullrecord <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_EP2007380B1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>EP2007380B1</sourcerecordid><originalsourceid>FETCH-epo_espacenet_EP2007380B13</originalsourceid><addsrcrecordid>eNrjZPAKDXZV8HdTcFTw9vRzBLI9_Tw8nTxD_IMU3IA4xMNVISTI1THE19UvBKQuwDEoxNM51McxSCHINdgzOMQRKB4S6usfFMzDwJqWmFOcyguluRkU3FxDnD10Uwvy41OLCxKTU_NSS-JdA4wMDMyNLQycDI2JUAIA9Sws-A</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>USE OF A KINASE INHIBITOR FOR THE TREATMENT OF PARTICULAR RESISTANT TUMORS</title><source>esp@cenet</source><creator>FANCELLI, DANIELE ; SONCINI, CHIARA ; RUSCONI, LUISA ; ISACCHI, ANTONELLA ; LUPI, ROSITA ; MODUGNO, MICHELE ; MOLL, JURGEN</creator><creatorcontrib>FANCELLI, DANIELE ; SONCINI, CHIARA ; RUSCONI, LUISA ; ISACCHI, ANTONELLA ; LUPI, ROSITA ; MODUGNO, MICHELE ; MOLL, JURGEN</creatorcontrib><description>The invention provides low molecular weight compounds, namely 1H-thieno[2,3-c]pyrazoles, showing a high affinity for the ATP pocket of ABL tyrosine kinase. These compounds are thus ATP-competitive tyrosine kinase inhibitors displaying a significant inhibitory potency also, and in particular, towards BCR-ABL inhibitor-resistant T315I ABL mutants. The compounds of the invention find a useful application in the treatment of BCR-ABL inhibitor-resistant ABL-mediated diseases, such as Imatinib-resistant chronic myelogenous leukemia. Moreover, the invention provides a screening method for the identification of compounds capable of binding the ATP pocket of a kinase protein, in particular of the T315I mutant ABL kinase.</description><language>eng ; fre ; ger</language><subject>HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2011</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&amp;date=20110914&amp;DB=EPODOC&amp;CC=EP&amp;NR=2007380B1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&amp;date=20110914&amp;DB=EPODOC&amp;CC=EP&amp;NR=2007380B1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>FANCELLI, DANIELE</creatorcontrib><creatorcontrib>SONCINI, CHIARA</creatorcontrib><creatorcontrib>RUSCONI, LUISA</creatorcontrib><creatorcontrib>ISACCHI, ANTONELLA</creatorcontrib><creatorcontrib>LUPI, ROSITA</creatorcontrib><creatorcontrib>MODUGNO, MICHELE</creatorcontrib><creatorcontrib>MOLL, JURGEN</creatorcontrib><title>USE OF A KINASE INHIBITOR FOR THE TREATMENT OF PARTICULAR RESISTANT TUMORS</title><description>The invention provides low molecular weight compounds, namely 1H-thieno[2,3-c]pyrazoles, showing a high affinity for the ATP pocket of ABL tyrosine kinase. These compounds are thus ATP-competitive tyrosine kinase inhibitors displaying a significant inhibitory potency also, and in particular, towards BCR-ABL inhibitor-resistant T315I ABL mutants. The compounds of the invention find a useful application in the treatment of BCR-ABL inhibitor-resistant ABL-mediated diseases, such as Imatinib-resistant chronic myelogenous leukemia. Moreover, the invention provides a screening method for the identification of compounds capable of binding the ATP pocket of a kinase protein, in particular of the T315I mutant ABL kinase.</description><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2011</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZPAKDXZV8HdTcFTw9vRzBLI9_Tw8nTxD_IMU3IA4xMNVISTI1THE19UvBKQuwDEoxNM51McxSCHINdgzOMQRKB4S6usfFMzDwJqWmFOcyguluRkU3FxDnD10Uwvy41OLCxKTU_NSS-JdA4wMDMyNLQycDI2JUAIA9Sws-A</recordid><startdate>20110914</startdate><enddate>20110914</enddate><creator>FANCELLI, DANIELE</creator><creator>SONCINI, CHIARA</creator><creator>RUSCONI, LUISA</creator><creator>ISACCHI, ANTONELLA</creator><creator>LUPI, ROSITA</creator><creator>MODUGNO, MICHELE</creator><creator>MOLL, JURGEN</creator><scope>EVB</scope></search><sort><creationdate>20110914</creationdate><title>USE OF A KINASE INHIBITOR FOR THE TREATMENT OF PARTICULAR RESISTANT TUMORS</title><author>FANCELLI, DANIELE ; SONCINI, CHIARA ; RUSCONI, LUISA ; ISACCHI, ANTONELLA ; LUPI, ROSITA ; MODUGNO, MICHELE ; MOLL, JURGEN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_EP2007380B13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre ; ger</language><creationdate>2011</creationdate><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>FANCELLI, DANIELE</creatorcontrib><creatorcontrib>SONCINI, CHIARA</creatorcontrib><creatorcontrib>RUSCONI, LUISA</creatorcontrib><creatorcontrib>ISACCHI, ANTONELLA</creatorcontrib><creatorcontrib>LUPI, ROSITA</creatorcontrib><creatorcontrib>MODUGNO, MICHELE</creatorcontrib><creatorcontrib>MOLL, JURGEN</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>FANCELLI, DANIELE</au><au>SONCINI, CHIARA</au><au>RUSCONI, LUISA</au><au>ISACCHI, ANTONELLA</au><au>LUPI, ROSITA</au><au>MODUGNO, MICHELE</au><au>MOLL, JURGEN</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>USE OF A KINASE INHIBITOR FOR THE TREATMENT OF PARTICULAR RESISTANT TUMORS</title><date>2011-09-14</date><risdate>2011</risdate><abstract>The invention provides low molecular weight compounds, namely 1H-thieno[2,3-c]pyrazoles, showing a high affinity for the ATP pocket of ABL tyrosine kinase. These compounds are thus ATP-competitive tyrosine kinase inhibitors displaying a significant inhibitory potency also, and in particular, towards BCR-ABL inhibitor-resistant T315I ABL mutants. The compounds of the invention find a useful application in the treatment of BCR-ABL inhibitor-resistant ABL-mediated diseases, such as Imatinib-resistant chronic myelogenous leukemia. Moreover, the invention provides a screening method for the identification of compounds capable of binding the ATP pocket of a kinase protein, in particular of the T315I mutant ABL kinase.</abstract><oa>free_for_read</oa></addata></record>
fulltext fulltext_linktorsrc
identifier
ispartof
issn
language eng ; fre ; ger
recordid cdi_epo_espacenet_EP2007380B1
source esp@cenet
subjects HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title USE OF A KINASE INHIBITOR FOR THE TREATMENT OF PARTICULAR RESISTANT TUMORS
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-11T04%3A24%3A42IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=FANCELLI,%20DANIELE&rft.date=2011-09-14&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3EEP2007380B1%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true