PROCESS FOR PRODUCING A SOLID DISPERSION OF AN ACTIVE INGREDIENT

PROCESS FOR PRODUCING A SOLID DISPERSION OF AN ACTIVE INGREDIENT

The present invention relates to a solid dispersion comprising a biologically active ingredient and a matrix-forming agent, wherein the biologically active ingredient comprises ritonavir and the solid dispersion has been obtained by a process which comprises feeding the active ingredient and a matri...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: BREITENBACH, JOERG, KESSLER, THOMAS, DEGENHARDT, MATTHIAS, KRULL, HARALD, SCHMIDT, CHRISTOPH, ROSENBERG, JOERG
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PERFORMING OPERATIONS
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDEDFOR
SHAPING OR JOINING OF PLASTICS
TRANSPORTING
WORKING OF PLASTICS
WORKING OF SUBSTANCES IN A PLASTIC STATE, IN GENERAL
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Beschreibung
Zusammenfassung:The present invention relates to a solid dispersion comprising a biologically active ingredient and a matrix-forming agent, wherein the biologically active ingredient comprises ritonavir and the solid dispersion has been obtained by a process which comprises feeding the active ingredient and a matrix-forming agent to an extruder and forming a uniform extrudate, wherein the extruder comprises at least two rotating shafts (2), each of the shafts (2) carrying a plurality of processing elements disposed axially one behind the other, the processing elements defining (i) a feeding and conveying section (A), (ii) at least one mixing section (B), and (iii) a discharging section (E), wherein the processing element(s) defining the mixing section (B) comprise(s) a mixing element (11, 12, 13) that is derived from a screw type element.