THE USE OF ORIPAVINE AS A STARTING MATERIAL FOR BUPRENORPHINE

There is provided a method for the synthesis of norbuprenorphine, and ultimately buprenorphine, utilizing oripavine as the starting material. Conventional methods of producing buprenorphine utilize thebaine as the starting material, requiring an O-demethylation step, typically a low to moderate yiel...

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Bibliographische Detailangaben

Hauptverfasser:	MANNINO, ANTHONY, HILL, LLOYD, P, BUEHLER, HENRY, J, HOEFGEN, ERIK, R
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY
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