METHODS AND COMPOSITION TO GENERATE UNIQUE SEQUENCE DNA PROBES, IABELING OF DNA PROBES AND THE USE OF THESE PROBES
A method for detecting the presence of a target sequence comprising: a. adding a probe, said probe having been produced by a method comprising: i. obtaining double strand polynucleotides known to contain complementary target sequences and repetitive sequences; ii. fragmenting said double strand poly...
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| creator | TIBBE, ARJAN, G.J TERSTAPPEN, LEON, W.M.M SWENNENHUIS, JOOST, F FOULK, BRAD VERRANT, JOHN, A CONNELLY, MARK, CARLE KAGAN, MICHAEL, T |
| description | A method for detecting the presence of a target sequence comprising:
a. adding a probe, said probe having been produced by a method comprising:
i. obtaining double strand polynucleotides known to contain complementary target sequences and repetitive sequences;
ii. fragmenting said double strand polynucleotides into fragments;
iii. denaturing said fragments into single strands;
iv. hybridizing said repetitive sequences to form a mixture of double strands and single strands;
v. cleaving said double strands; and
vi. amplifying said single strands wherein said single strands are complementary to said target sequences; and
b. detecting said probe wherein said detection is selected from a group consisting of ISH, FISH, CGH, spectral karyotyping, chromosome painting, Northern blots, Southern blots, microarray analysis, and combinations thereof. |
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a. adding a probe, said probe having been produced by a method comprising:
i. obtaining double strand polynucleotides known to contain complementary target sequences and repetitive sequences;
ii. fragmenting said double strand polynucleotides into fragments;
iii. denaturing said fragments into single strands;
iv. hybridizing said repetitive sequences to form a mixture of double strands and single strands;
v. cleaving said double strands; and
vi. amplifying said single strands wherein said single strands are complementary to said target sequences; and
b. detecting said probe wherein said detection is selected from a group consisting of ISH, FISH, CGH, spectral karyotyping, chromosome painting, Northern blots, Southern blots, microarray analysis, and combinations thereof.</description><language>eng ; fre ; ger</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; DERIVATIVES THEREOF ; ENZYMOLOGY ; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE ; METALLURGY ; MICROBIOLOGY ; MUTATION OR GENETIC ENGINEERING ; NUCLEIC ACIDS ; NUCLEOSIDES ; NUCLEOTIDES ; ORGANIC CHEMISTRY ; SPIRITS ; SUGARS ; VINEGAR ; WINE</subject><creationdate>2009</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20090624&DB=EPODOC&CC=EP&NR=1941050A4$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,777,882,25545,76296</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20090624&DB=EPODOC&CC=EP&NR=1941050A4$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>TIBBE, ARJAN, G.J</creatorcontrib><creatorcontrib>TERSTAPPEN, LEON, W.M.M</creatorcontrib><creatorcontrib>SWENNENHUIS, JOOST, F</creatorcontrib><creatorcontrib>FOULK, BRAD</creatorcontrib><creatorcontrib>VERRANT, JOHN, A</creatorcontrib><creatorcontrib>CONNELLY, MARK, CARLE</creatorcontrib><creatorcontrib>KAGAN, MICHAEL, T</creatorcontrib><title>METHODS AND COMPOSITION TO GENERATE UNIQUE SEQUENCE DNA PROBES, IABELING OF DNA PROBES AND THE USE OF THESE PROBES</title><description>A method for detecting the presence of a target sequence comprising:
a. adding a probe, said probe having been produced by a method comprising:
i. obtaining double strand polynucleotides known to contain complementary target sequences and repetitive sequences;
ii. fragmenting said double strand polynucleotides into fragments;
iii. denaturing said fragments into single strands;
iv. hybridizing said repetitive sequences to form a mixture of double strands and single strands;
v. cleaving said double strands; and
vi. amplifying said single strands wherein said single strands are complementary to said target sequences; and
b. detecting said probe wherein said detection is selected from a group consisting of ISH, FISH, CGH, spectral karyotyping, chromosome painting, Northern blots, Southern blots, microarray analysis, and combinations thereof.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>DERIVATIVES THEREOF</subject><subject>ENZYMOLOGY</subject><subject>FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>NUCLEIC ACIDS</subject><subject>NUCLEOSIDES</subject><subject>NUCLEOTIDES</subject><subject>ORGANIC CHEMISTRY</subject><subject>SPIRITS</subject><subject>SUGARS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2009</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNTDkOwjAQdEOBgD_sA0BKRCgoHXsTWyK7JnbqKEKmQhAR_i_MUVDSzIzmmot7g8Gw9iBJg-LGsbfBMkFgqJGwlQGhI3vsEDwmJIWgSYJruUS_BitLPFiqgasf_30XTJp6fCVJJvHJlmJ2Hi5TXH15IaDCoMwmjrc-TuNwitf46NHl-yLPdpkstn9UnoeQNzo</recordid><startdate>20090624</startdate><enddate>20090624</enddate><creator>TIBBE, ARJAN, G.J</creator><creator>TERSTAPPEN, LEON, W.M.M</creator><creator>SWENNENHUIS, JOOST, F</creator><creator>FOULK, BRAD</creator><creator>VERRANT, JOHN, A</creator><creator>CONNELLY, MARK, CARLE</creator><creator>KAGAN, MICHAEL, T</creator><scope>EVB</scope></search><sort><creationdate>20090624</creationdate><title>METHODS AND COMPOSITION TO GENERATE UNIQUE SEQUENCE DNA PROBES, IABELING OF DNA PROBES AND THE USE OF THESE PROBES</title><author>TIBBE, ARJAN, G.J ; TERSTAPPEN, LEON, W.M.M ; SWENNENHUIS, JOOST, F ; FOULK, BRAD ; VERRANT, JOHN, A ; CONNELLY, MARK, CARLE ; KAGAN, MICHAEL, T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_EP1941050A43</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre ; ger</language><creationdate>2009</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>DERIVATIVES THEREOF</topic><topic>ENZYMOLOGY</topic><topic>FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>NUCLEIC ACIDS</topic><topic>NUCLEOSIDES</topic><topic>NUCLEOTIDES</topic><topic>ORGANIC CHEMISTRY</topic><topic>SPIRITS</topic><topic>SUGARS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>TIBBE, ARJAN, G.J</creatorcontrib><creatorcontrib>TERSTAPPEN, LEON, W.M.M</creatorcontrib><creatorcontrib>SWENNENHUIS, JOOST, F</creatorcontrib><creatorcontrib>FOULK, BRAD</creatorcontrib><creatorcontrib>VERRANT, JOHN, A</creatorcontrib><creatorcontrib>CONNELLY, MARK, CARLE</creatorcontrib><creatorcontrib>KAGAN, MICHAEL, T</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>TIBBE, ARJAN, G.J</au><au>TERSTAPPEN, LEON, W.M.M</au><au>SWENNENHUIS, JOOST, F</au><au>FOULK, BRAD</au><au>VERRANT, JOHN, A</au><au>CONNELLY, MARK, CARLE</au><au>KAGAN, MICHAEL, T</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>METHODS AND COMPOSITION TO GENERATE UNIQUE SEQUENCE DNA PROBES, IABELING OF DNA PROBES AND THE USE OF THESE PROBES</title><date>2009-06-24</date><risdate>2009</risdate><abstract>A method for detecting the presence of a target sequence comprising:
a. adding a probe, said probe having been produced by a method comprising:
i. obtaining double strand polynucleotides known to contain complementary target sequences and repetitive sequences;
ii. fragmenting said double strand polynucleotides into fragments;
iii. denaturing said fragments into single strands;
iv. hybridizing said repetitive sequences to form a mixture of double strands and single strands;
v. cleaving said double strands; and
vi. amplifying said single strands wherein said single strands are complementary to said target sequences; and
b. detecting said probe wherein said detection is selected from a group consisting of ISH, FISH, CGH, spectral karyotyping, chromosome painting, Northern blots, Southern blots, microarray analysis, and combinations thereof.</abstract><oa>free_for_read</oa></addata></record> |
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| language | eng ; fre ; ger |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY DERIVATIVES THEREOF ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY SPIRITS SUGARS VINEGAR WINE |
| title | METHODS AND COMPOSITION TO GENERATE UNIQUE SEQUENCE DNA PROBES, IABELING OF DNA PROBES AND THE USE OF THESE PROBES |
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