QUANTITATIVE ASSAYS FOR PDGFR-beta IN BODY FLUIDS

The present invention is directed to the detection and quantification of total PDGFR-beta in body fluids, particularly serial changes of total PDGFR-beta levels in a subject's body fluids. Further, the invention is directed to detecting and quantitatiing total PDGFR-beta in conjunction with one...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	MORRIS, LETICIA, HAMER, PETER, J, CARNEY, WALTER, P, ELTING, JAMES
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING PHYSICS TESTING
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Beschreibung
Zusammenfassung:	The present invention is directed to the detection and quantification of total PDGFR-beta in body fluids, particularly serial changes of total PDGFR-beta levels in a subject's body fluids. Further, the invention is directed to detecting and quantitatiing total PDGFR-beta in conjunction with one or more other proteins, such as, oncoproteins, angiogenic factors, tumor markers, inhibitors, growth factor receptors, metastasis proteins, and tumor suppressors. The disclosed methods are diagnostic/prognostic for diseases, and useful to select therapies for patients with diseases, preferably preneoplastic/neoplastic diseases. The disclosed methods are particularly useful to monitor the status of a patient's disease, and/or to monitor how a patient is responding to a therapy.