LABEL-FREE HIGH THROUGHPUT BIOMOLECULAR SCREENING SYSTEM AND METHOD

LABEL-FREE HIGH THROUGHPUT BIOMOLECULAR SCREENING SYSTEM AND METHOD

A screening system and method are described herein which provide a unique and practical solution for enabling label-free high throughput screening (HTS) to aid in the discovery of new drugs. In one embodiment, the screening system enables direct binding assays to be performed in which a biomolecular...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: KROL, MARK, F, MOORE, THOMAS, C, PASTEL, DAVID, A, CARRACCI, STEPHEN, J, ECKELT, VOLKER, H, FRUTOS, ANTHONY, G, SHEDD, GORDON, M
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
PHYSICS
TESTING
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page
container_issue
container_start_page
container_title
container_volume
creator KROL, MARK, F
MOORE, THOMAS, C
PASTEL, DAVID, A
CARRACCI, STEPHEN, J
ECKELT, VOLKER, H
FRUTOS, ANTHONY, G
SHEDD, GORDON, M
description A screening system and method are described herein which provide a unique and practical solution for enabling label-free high throughput screening (HTS) to aid in the discovery of new drugs. In one embodiment, the screening system enables direct binding assays to be performed in which a biomolecular interaction of a chemical compound (drug candidate) with a biomolecule (therapeutic target) can be detected using assay volumes and concentrations that are compatible with the current practices of HTS in the pharmaceutical industry. The screening system also enables the detection of bio-chemical interactions that occur in the wells of a microplate which incorporates biosensors and surface chemistry to immobilize the therapeutic target at the surface of the biosensors. The screening system also includes fluid handling and plate handling devices to help perform automated HTS assays.
format Patent
fullrecord <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_EP1904858A1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>EP1904858A1</sourcerecordid><originalsourceid>FETCH-epo_espacenet_EP1904858A13</originalsourceid><addsrcrecordid>eNrjZHD2cXRy9dF1C3J1VfDwdPdQCPEI8g919wgIDVFw8vT39fdxdQ71cQxSCHYGKvHz9HNXCI4MDnH1VXD0c1HwdQ3x8HfhYWBNS8wpTuWF0twMCm6uIc4euqkF-fGpxQWJyal5qSXxrgGGlgYmFqYWjobGRCgBAN8IKzY</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>LABEL-FREE HIGH THROUGHPUT BIOMOLECULAR SCREENING SYSTEM AND METHOD</title><source>esp@cenet</source><creator>KROL, MARK, F ; MOORE, THOMAS, C ; PASTEL, DAVID, A ; CARRACCI, STEPHEN, J ; ECKELT, VOLKER, H ; FRUTOS, ANTHONY, G ; SHEDD, GORDON, M</creator><creatorcontrib>KROL, MARK, F ; MOORE, THOMAS, C ; PASTEL, DAVID, A ; CARRACCI, STEPHEN, J ; ECKELT, VOLKER, H ; FRUTOS, ANTHONY, G ; SHEDD, GORDON, M</creatorcontrib><description>A screening system and method are described herein which provide a unique and practical solution for enabling label-free high throughput screening (HTS) to aid in the discovery of new drugs. In one embodiment, the screening system enables direct binding assays to be performed in which a biomolecular interaction of a chemical compound (drug candidate) with a biomolecule (therapeutic target) can be detected using assay volumes and concentrations that are compatible with the current practices of HTS in the pharmaceutical industry. The screening system also enables the detection of bio-chemical interactions that occur in the wells of a microplate which incorporates biosensors and surface chemistry to immobilize the therapeutic target at the surface of the biosensors. The screening system also includes fluid handling and plate handling devices to help perform automated HTS assays.</description><language>eng ; fre ; ger</language><subject>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES ; MEASURING ; PHYSICS ; TESTING</subject><creationdate>2008</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&amp;date=20080402&amp;DB=EPODOC&amp;CC=EP&amp;NR=1904858A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,777,882,25545,76296</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&amp;date=20080402&amp;DB=EPODOC&amp;CC=EP&amp;NR=1904858A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>KROL, MARK, F</creatorcontrib><creatorcontrib>MOORE, THOMAS, C</creatorcontrib><creatorcontrib>PASTEL, DAVID, A</creatorcontrib><creatorcontrib>CARRACCI, STEPHEN, J</creatorcontrib><creatorcontrib>ECKELT, VOLKER, H</creatorcontrib><creatorcontrib>FRUTOS, ANTHONY, G</creatorcontrib><creatorcontrib>SHEDD, GORDON, M</creatorcontrib><title>LABEL-FREE HIGH THROUGHPUT BIOMOLECULAR SCREENING SYSTEM AND METHOD</title><description>A screening system and method are described herein which provide a unique and practical solution for enabling label-free high throughput screening (HTS) to aid in the discovery of new drugs. In one embodiment, the screening system enables direct binding assays to be performed in which a biomolecular interaction of a chemical compound (drug candidate) with a biomolecule (therapeutic target) can be detected using assay volumes and concentrations that are compatible with the current practices of HTS in the pharmaceutical industry. The screening system also enables the detection of bio-chemical interactions that occur in the wells of a microplate which incorporates biosensors and surface chemistry to immobilize the therapeutic target at the surface of the biosensors. The screening system also includes fluid handling and plate handling devices to help perform automated HTS assays.</description><subject>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</subject><subject>MEASURING</subject><subject>PHYSICS</subject><subject>TESTING</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2008</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZHD2cXRy9dF1C3J1VfDwdPdQCPEI8g919wgIDVFw8vT39fdxdQ71cQxSCHYGKvHz9HNXCI4MDnH1VXD0c1HwdQ3x8HfhYWBNS8wpTuWF0twMCm6uIc4euqkF-fGpxQWJyal5qSXxrgGGlgYmFqYWjobGRCgBAN8IKzY</recordid><startdate>20080402</startdate><enddate>20080402</enddate><creator>KROL, MARK, F</creator><creator>MOORE, THOMAS, C</creator><creator>PASTEL, DAVID, A</creator><creator>CARRACCI, STEPHEN, J</creator><creator>ECKELT, VOLKER, H</creator><creator>FRUTOS, ANTHONY, G</creator><creator>SHEDD, GORDON, M</creator><scope>EVB</scope></search><sort><creationdate>20080402</creationdate><title>LABEL-FREE HIGH THROUGHPUT BIOMOLECULAR SCREENING SYSTEM AND METHOD</title><author>KROL, MARK, F ; MOORE, THOMAS, C ; PASTEL, DAVID, A ; CARRACCI, STEPHEN, J ; ECKELT, VOLKER, H ; FRUTOS, ANTHONY, G ; SHEDD, GORDON, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_EP1904858A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre ; ger</language><creationdate>2008</creationdate><topic>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</topic><topic>MEASURING</topic><topic>PHYSICS</topic><topic>TESTING</topic><toplevel>online_resources</toplevel><creatorcontrib>KROL, MARK, F</creatorcontrib><creatorcontrib>MOORE, THOMAS, C</creatorcontrib><creatorcontrib>PASTEL, DAVID, A</creatorcontrib><creatorcontrib>CARRACCI, STEPHEN, J</creatorcontrib><creatorcontrib>ECKELT, VOLKER, H</creatorcontrib><creatorcontrib>FRUTOS, ANTHONY, G</creatorcontrib><creatorcontrib>SHEDD, GORDON, M</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>KROL, MARK, F</au><au>MOORE, THOMAS, C</au><au>PASTEL, DAVID, A</au><au>CARRACCI, STEPHEN, J</au><au>ECKELT, VOLKER, H</au><au>FRUTOS, ANTHONY, G</au><au>SHEDD, GORDON, M</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>LABEL-FREE HIGH THROUGHPUT BIOMOLECULAR SCREENING SYSTEM AND METHOD</title><date>2008-04-02</date><risdate>2008</risdate><abstract>A screening system and method are described herein which provide a unique and practical solution for enabling label-free high throughput screening (HTS) to aid in the discovery of new drugs. In one embodiment, the screening system enables direct binding assays to be performed in which a biomolecular interaction of a chemical compound (drug candidate) with a biomolecule (therapeutic target) can be detected using assay volumes and concentrations that are compatible with the current practices of HTS in the pharmaceutical industry. The screening system also enables the detection of bio-chemical interactions that occur in the wells of a microplate which incorporates biosensors and surface chemistry to immobilize the therapeutic target at the surface of the biosensors. The screening system also includes fluid handling and plate handling devices to help perform automated HTS assays.</abstract><oa>free_for_read</oa></addata></record>
fulltext fulltext_linktorsrc
identifier
ispartof
issn
language eng ; fre ; ger
recordid cdi_epo_espacenet_EP1904858A1
source esp@cenet
subjects INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
PHYSICS
TESTING
title LABEL-FREE HIGH THROUGHPUT BIOMOLECULAR SCREENING SYSTEM AND METHOD
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-20T06%3A00%3A29IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=KROL,%20MARK,%20F&rft.date=2008-04-02&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3EEP1904858A1%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true