2-AMINOQUINAZOLINE DERIVATIVES
The present invention provides 2-aminoquinazoline derivatives represented by formula (I): wherein R 1 and R 2 may be the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, and the like; X represents a bond or CR 7a R 7b wherein R 7a and R 7b may be the s...
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| creator | IKEMURA, TOSHIHIDE KASHIMA, HAJIME MORI, KIYOTOSHI KISHIKAWA, KUNIYUKI IMASE, HIDETOMO NAKASATO, YOSHISUKE TOMURO, MISATO |
| description | The present invention provides 2-aminoquinazoline derivatives represented by formula (I):
wherein R 1 and R 2 may be the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, and the like;
X represents a bond or CR 7a R 7b wherein R 7a and R 7b may be the same or different and each represents a hydrogen atom, and the like;
when X is a bond, R 3 represents substituted or unsubstituted aryl or a substituted or unsubstituted aromatic heterocyclic group;
when X is CR 7a R 7b wherein R 7a and R 7b have the same meanings as defined above, respectively, R 3 represents substituted or unsubstituted lower alkoxy, substituted or unsubstituted aryl, and the like;
R 4 represents a hydrogen atom, hydroxy, substituted or unsubstituted lower alkoxy, and the like; and
R 5 represents a hydrogen atom, substituted or unsubstituted aryl, and the like, or a pharmaceutically acceptable salt thereof. |
| format | Patent |
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wherein R 1 and R 2 may be the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, and the like;
X represents a bond or CR 7a R 7b wherein R 7a and R 7b may be the same or different and each represents a hydrogen atom, and the like;
when X is a bond, R 3 represents substituted or unsubstituted aryl or a substituted or unsubstituted aromatic heterocyclic group;
when X is CR 7a R 7b wherein R 7a and R 7b have the same meanings as defined above, respectively, R 3 represents substituted or unsubstituted lower alkoxy, substituted or unsubstituted aryl, and the like;
R 4 represents a hydrogen atom, hydroxy, substituted or unsubstituted lower alkoxy, and the like; and
R 5 represents a hydrogen atom, substituted or unsubstituted aryl, and the like, or a pharmaceutically acceptable salt thereof.</description><language>eng ; fre ; ger</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2008</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20080116&DB=EPODOC&CC=EP&NR=1878727A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25543,76293</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20080116&DB=EPODOC&CC=EP&NR=1878727A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>IKEMURA, TOSHIHIDE</creatorcontrib><creatorcontrib>KASHIMA, HAJIME</creatorcontrib><creatorcontrib>MORI, KIYOTOSHI</creatorcontrib><creatorcontrib>KISHIKAWA, KUNIYUKI</creatorcontrib><creatorcontrib>IMASE, HIDETOMO</creatorcontrib><creatorcontrib>NAKASATO, YOSHISUKE</creatorcontrib><creatorcontrib>TOMURO, MISATO</creatorcontrib><title>2-AMINOQUINAZOLINE DERIVATIVES</title><description>The present invention provides 2-aminoquinazoline derivatives represented by formula (I):
wherein R 1 and R 2 may be the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, and the like;
X represents a bond or CR 7a R 7b wherein R 7a and R 7b may be the same or different and each represents a hydrogen atom, and the like;
when X is a bond, R 3 represents substituted or unsubstituted aryl or a substituted or unsubstituted aromatic heterocyclic group;
when X is CR 7a R 7b wherein R 7a and R 7b have the same meanings as defined above, respectively, R 3 represents substituted or unsubstituted lower alkoxy, substituted or unsubstituted aryl, and the like;
R 4 represents a hydrogen atom, hydroxy, substituted or unsubstituted lower alkoxy, and the like; and
R 5 represents a hydrogen atom, substituted or unsubstituted aryl, and the like, or a pharmaceutically acceptable salt thereof.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2008</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZJAz0nX09fTzDwz19HOM8vfx9HNVcHEN8gxzDPEMcw3mYWBNS8wpTuWF0twMCm6uIc4euqkF-fGpxQWJyal5qSXxrgGGFuYW5kbmjobGRCgBAIluIUU</recordid><startdate>20080116</startdate><enddate>20080116</enddate><creator>IKEMURA, TOSHIHIDE</creator><creator>KASHIMA, HAJIME</creator><creator>MORI, KIYOTOSHI</creator><creator>KISHIKAWA, KUNIYUKI</creator><creator>IMASE, HIDETOMO</creator><creator>NAKASATO, YOSHISUKE</creator><creator>TOMURO, MISATO</creator><scope>EVB</scope></search><sort><creationdate>20080116</creationdate><title>2-AMINOQUINAZOLINE DERIVATIVES</title><author>IKEMURA, TOSHIHIDE ; KASHIMA, HAJIME ; MORI, KIYOTOSHI ; KISHIKAWA, KUNIYUKI ; IMASE, HIDETOMO ; NAKASATO, YOSHISUKE ; TOMURO, MISATO</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_EP1878727A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre ; ger</language><creationdate>2008</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>IKEMURA, TOSHIHIDE</creatorcontrib><creatorcontrib>KASHIMA, HAJIME</creatorcontrib><creatorcontrib>MORI, KIYOTOSHI</creatorcontrib><creatorcontrib>KISHIKAWA, KUNIYUKI</creatorcontrib><creatorcontrib>IMASE, HIDETOMO</creatorcontrib><creatorcontrib>NAKASATO, YOSHISUKE</creatorcontrib><creatorcontrib>TOMURO, MISATO</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>IKEMURA, TOSHIHIDE</au><au>KASHIMA, HAJIME</au><au>MORI, KIYOTOSHI</au><au>KISHIKAWA, KUNIYUKI</au><au>IMASE, HIDETOMO</au><au>NAKASATO, YOSHISUKE</au><au>TOMURO, MISATO</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>2-AMINOQUINAZOLINE DERIVATIVES</title><date>2008-01-16</date><risdate>2008</risdate><abstract>The present invention provides 2-aminoquinazoline derivatives represented by formula (I):
wherein R 1 and R 2 may be the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, and the like;
X represents a bond or CR 7a R 7b wherein R 7a and R 7b may be the same or different and each represents a hydrogen atom, and the like;
when X is a bond, R 3 represents substituted or unsubstituted aryl or a substituted or unsubstituted aromatic heterocyclic group;
when X is CR 7a R 7b wherein R 7a and R 7b have the same meanings as defined above, respectively, R 3 represents substituted or unsubstituted lower alkoxy, substituted or unsubstituted aryl, and the like;
R 4 represents a hydrogen atom, hydroxy, substituted or unsubstituted lower alkoxy, and the like; and
R 5 represents a hydrogen atom, substituted or unsubstituted aryl, and the like, or a pharmaceutically acceptable salt thereof.</abstract><oa>free_for_read</oa></addata></record> |
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| language | eng ; fre ; ger |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | 2-AMINOQUINAZOLINE DERIVATIVES |
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