Substituted aminopyrazolopyridines and salts thereof, their preparations and pharmaceutical compositions comprising them
The invention relates to substituted aminopyrazolopyridines according to the general formula (I) : in which A, B, D, E, R a , R 1 , R 2 , R 3 , R 4 , R 5 and q are as defined in the claims, and salts thereof, to pharmaceutical compositions comprising said substituted aminopyrazolopyridines, to metho...
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| creator | THIERAUCH, KARL-HEINZ INCE, STUART HARTUNG, INGO KETTSCHAU, GEORG BRIEM, HANS TER LAAK, ANTONIUS SCHWEDE, WOLFGANG |
| description | The invention relates to substituted aminopyrazolopyridines according to the general formula (I) :
in which A, B, D, E, R a , R 1 , R 2 , R 3 , R 4 , R 5 and q are as defined in the claims, and salts thereof, to pharmaceutical compositions comprising said substituted aminopyrazolopyridines, to methods of preparing said substituted aminopyrazolopyridines as well as the use thereof for manufacturing a pharmaceutical composition for the treatment of diseases of dysregulated vascular growth or of diseases which are accompanied with dysregulated vascular growth, wherein the compounds effectively interfere with Tie2 signalling. |
| format | Patent |
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in which A, B, D, E, R a , R 1 , R 2 , R 3 , R 4 , R 5 and q are as defined in the claims, and salts thereof, to pharmaceutical compositions comprising said substituted aminopyrazolopyridines, to methods of preparing said substituted aminopyrazolopyridines as well as the use thereof for manufacturing a pharmaceutical composition for the treatment of diseases of dysregulated vascular growth or of diseases which are accompanied with dysregulated vascular growth, wherein the compounds effectively interfere with Tie2 signalling.</description><language>eng ; fre ; ger</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2007</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20071219&DB=EPODOC&CC=EP&NR=1867647A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,778,883,25547,76298</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20071219&DB=EPODOC&CC=EP&NR=1867647A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>THIERAUCH, KARL-HEINZ</creatorcontrib><creatorcontrib>INCE, STUART</creatorcontrib><creatorcontrib>HARTUNG, INGO</creatorcontrib><creatorcontrib>KETTSCHAU, GEORG</creatorcontrib><creatorcontrib>BRIEM, HANS</creatorcontrib><creatorcontrib>TER LAAK, ANTONIUS</creatorcontrib><creatorcontrib>SCHWEDE, WOLFGANG</creatorcontrib><title>Substituted aminopyrazolopyridines and salts thereof, their preparations and pharmaceutical compositions comprising them</title><description>The invention relates to substituted aminopyrazolopyridines according to the general formula (I) :
in which A, B, D, E, R a , R 1 , R 2 , R 3 , R 4 , R 5 and q are as defined in the claims, and salts thereof, to pharmaceutical compositions comprising said substituted aminopyrazolopyridines, to methods of preparing said substituted aminopyrazolopyridines as well as the use thereof for manufacturing a pharmaceutical composition for the treatment of diseases of dysregulated vascular growth or of diseases which are accompanied with dysregulated vascular growth, wherein the compounds effectively interfere with Tie2 signalling.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2007</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNjL0KwkAQhNNYiPoO-wBaBCWxFYlYCtqHNdmYhfvjdg_Up9cjPoDVzDDfzLx4XtNdlDUp9YCWnQ-viG9vsnLPjgTQ9SBoVEBHiuSHdTYcIUQKGFHZu4kKI0aLHSXlDg103gYvPPU5RBZ2j7y2y2I2oBFa_XRRwKm5Hc8bCr4lCd8XR9o2l3Jf1dWuPpTbP5APg6ZILQ</recordid><startdate>20071219</startdate><enddate>20071219</enddate><creator>THIERAUCH, KARL-HEINZ</creator><creator>INCE, STUART</creator><creator>HARTUNG, INGO</creator><creator>KETTSCHAU, GEORG</creator><creator>BRIEM, HANS</creator><creator>TER LAAK, ANTONIUS</creator><creator>SCHWEDE, WOLFGANG</creator><scope>EVB</scope></search><sort><creationdate>20071219</creationdate><title>Substituted aminopyrazolopyridines and salts thereof, their preparations and pharmaceutical compositions comprising them</title><author>THIERAUCH, KARL-HEINZ ; INCE, STUART ; HARTUNG, INGO ; KETTSCHAU, GEORG ; BRIEM, HANS ; TER LAAK, ANTONIUS ; SCHWEDE, WOLFGANG</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_EP1867647A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre ; ger</language><creationdate>2007</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>THIERAUCH, KARL-HEINZ</creatorcontrib><creatorcontrib>INCE, STUART</creatorcontrib><creatorcontrib>HARTUNG, INGO</creatorcontrib><creatorcontrib>KETTSCHAU, GEORG</creatorcontrib><creatorcontrib>BRIEM, HANS</creatorcontrib><creatorcontrib>TER LAAK, ANTONIUS</creatorcontrib><creatorcontrib>SCHWEDE, WOLFGANG</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>THIERAUCH, KARL-HEINZ</au><au>INCE, STUART</au><au>HARTUNG, INGO</au><au>KETTSCHAU, GEORG</au><au>BRIEM, HANS</au><au>TER LAAK, ANTONIUS</au><au>SCHWEDE, WOLFGANG</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Substituted aminopyrazolopyridines and salts thereof, their preparations and pharmaceutical compositions comprising them</title><date>2007-12-19</date><risdate>2007</risdate><abstract>The invention relates to substituted aminopyrazolopyridines according to the general formula (I) :
in which A, B, D, E, R a , R 1 , R 2 , R 3 , R 4 , R 5 and q are as defined in the claims, and salts thereof, to pharmaceutical compositions comprising said substituted aminopyrazolopyridines, to methods of preparing said substituted aminopyrazolopyridines as well as the use thereof for manufacturing a pharmaceutical composition for the treatment of diseases of dysregulated vascular growth or of diseases which are accompanied with dysregulated vascular growth, wherein the compounds effectively interfere with Tie2 signalling.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Substituted aminopyrazolopyridines and salts thereof, their preparations and pharmaceutical compositions comprising them |
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