CHOLANIC ACID-CHITOSAN COMPLEX FORMING SELF-AGGREGATES AND PREPARATION METHOD THEREOF
Disclosed are a pharmaceutical formulation characterized in that hydrophobic anticancer drugs are incorporated into a cholanic acid-chitosan complex and a preparation method thereof, and more particularly, the cholanic acid-chitosan complex composing of hydrophobic cholanic acid and hydrophilic chit...
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| creator | CHUNG, Hesson JEONG, Seo Young KIM, Jong-ho SEO, Sang Bong KWON, Ick Chan KIM, In-san PARK, Jae Hyung KIM, Kwangmyung KWON, Seunglee |
| description | Disclosed are a pharmaceutical formulation characterized in that hydrophobic anticancer drugs are incorporated into a cholanic acid-chitosan complex and a preparation method thereof, and more particularly, the cholanic acid-chitosan complex composing of hydrophobic cholanic acid and hydrophilic chitosan forms self-aggregates in an aquatic environment. The pharmaceutical formulation characterized in that hydrophobic anticancer drugs are incorporated into a cholanic acid-chitosan complex, wherein the cholanic acid-chitosan complex forms self-aggregates, prolongs the drug release period, enhances the selectivity of the complex for tumor tissue, and greatly increases drug loading content when a drug is incorporated into the self-aggregates, compared to chemical bonding, which limits drug incorporation. Thus, the pharmaceutical formulation of the present invention is useful for anticancer chemotherapy. |
| format | Patent |
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The pharmaceutical formulation characterized in that hydrophobic anticancer drugs are incorporated into a cholanic acid-chitosan complex, wherein the cholanic acid-chitosan complex forms self-aggregates, prolongs the drug release period, enhances the selectivity of the complex for tumor tissue, and greatly increases drug loading content when a drug is incorporated into the self-aggregates, compared to chemical bonding, which limits drug incorporation. 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The pharmaceutical formulation characterized in that hydrophobic anticancer drugs are incorporated into a cholanic acid-chitosan complex, wherein the cholanic acid-chitosan complex forms self-aggregates, prolongs the drug release period, enhances the selectivity of the complex for tumor tissue, and greatly increases drug loading content when a drug is incorporated into the self-aggregates, compared to chemical bonding, which limits drug incorporation. Thus, the pharmaceutical formulation of the present invention is useful for anticancer chemotherapy.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES |
| title | CHOLANIC ACID-CHITOSAN COMPLEX FORMING SELF-AGGREGATES AND PREPARATION METHOD THEREOF |
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