NEW MODIFIED RELEASE TABLET FORMULATIONS FOR PROTON PUMP INHIBITORS

NEW MODIFIED RELEASE TABLET FORMULATIONS FOR PROTON PUMP INHIBITORS

An oral solid pharmaceutical dosage form comprising an acid sensitive proton pump inhibitor (PPI) as single active drug, releasing the PPI in two separate pulses, one immediate and one delayed. The PPI is formulated into a core material in the form of tablets, which are coated i.a. with a combinatio...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: WANG, PETER, LOEFROTH, JAN-ERIK, CLEMMENSEN, NICLAS, WIKBERG, MARTIN, SAHLEN, HENRIK, WALTER, KATRIN
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:An oral solid pharmaceutical dosage form comprising an acid sensitive proton pump inhibitor (PPI) as single active drug, releasing the PPI in two separate pulses, one immediate and one delayed. The PPI is formulated into a core material in the form of tablets, which are coated i.a. with a combination of a delay release modifying layer and a lag time controlling layer that together achieves beneficial release properties. The tablets are further provided with an enteric coating layer. The application also relates to processes for preparing the dosage forms as well as their use in the treatment of gastrointestinal diseases.