Antitumoral pharmaceutical composition containing polypeptide fragments of serralysins
The present invention is related to a composition capable of inhibiting the growth of tumoral cells of different histological origins and of activated endothelial cells. The components of said compositions are polypeptide fragments of the serralisins, corresponding to the C-terminal fragment, from t...
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| creator | BEQUET ROMERO, MONICA VELIZ RIOS, GLORIA GARCIA SUAREZ, JOSE GOMEZ RIERA, RAUL GAVILONDO COWLEY, JORGE VICTOR CASTELLANOS SERRA, LILA ROSA REYES GONZALEZ, JESUS ABRAHANTES PEREZ, MARIA DEL CARMEN MARTINEZ DIAZ, EDUARDO SELMAN-HOUSEIN SOSA, MANUEL GASMURI GONZALEZ, CARIDAD ANAIS GONZALEZ LOPEZ, LUIS JAVIER |
| description | The present invention is related to a composition capable of inhibiting the growth of tumoral cells of different histological origins and of activated endothelial cells. The components of said compositions are polypeptide fragments of the serralisins, corresponding to the C-terminal fragment, from the internal metionine trough the end of the molecule, which could be combined among them and optionally with the prodigiosins that potentiate the antitumoral effect of the composition. The prodigiosins in the composition could be at a concentration of 0.1 - 100 nM. The anti-proliferative action of this composition is mediated by apoptotic mechanism. It's "in vivo" administration has antitumoral, antiangiogenic and protective effect against malignant tumors. |
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The components of said compositions are polypeptide fragments of the serralisins, corresponding to the C-terminal fragment, from the internal metionine trough the end of the molecule, which could be combined among them and optionally with the prodigiosins that potentiate the antitumoral effect of the composition. The prodigiosins in the composition could be at a concentration of 0.1 - 100 nM. The anti-proliferative action of this composition is mediated by apoptotic mechanism. It's "in vivo" administration has antitumoral, antiangiogenic and protective effect against malignant tumors.</description><language>eng ; fre ; ger</language><subject>CHEMISTRY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PEPTIDES ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2007</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20070523&DB=EPODOC&CC=EP&NR=1787653A2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20070523&DB=EPODOC&CC=EP&NR=1787653A2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>BEQUET ROMERO, MONICA</creatorcontrib><creatorcontrib>VELIZ RIOS, GLORIA</creatorcontrib><creatorcontrib>GARCIA SUAREZ, JOSE</creatorcontrib><creatorcontrib>GOMEZ RIERA, RAUL</creatorcontrib><creatorcontrib>GAVILONDO COWLEY, JORGE VICTOR</creatorcontrib><creatorcontrib>CASTELLANOS SERRA, LILA ROSA</creatorcontrib><creatorcontrib>REYES GONZALEZ, JESUS</creatorcontrib><creatorcontrib>ABRAHANTES PEREZ, MARIA DEL CARMEN</creatorcontrib><creatorcontrib>MARTINEZ DIAZ, EDUARDO</creatorcontrib><creatorcontrib>SELMAN-HOUSEIN SOSA, MANUEL</creatorcontrib><creatorcontrib>GASMURI GONZALEZ, CARIDAD ANAIS</creatorcontrib><creatorcontrib>GONZALEZ LOPEZ, LUIS JAVIER</creatorcontrib><title>Antitumoral pharmaceutical composition containing polypeptide fragments of serralysins</title><description>The present invention is related to a composition capable of inhibiting the growth of tumoral cells of different histological origins and of activated endothelial cells. 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The components of said compositions are polypeptide fragments of the serralisins, corresponding to the C-terminal fragment, from the internal metionine trough the end of the molecule, which could be combined among them and optionally with the prodigiosins that potentiate the antitumoral effect of the composition. The prodigiosins in the composition could be at a concentration of 0.1 - 100 nM. The anti-proliferative action of this composition is mediated by apoptotic mechanism. It's "in vivo" administration has antitumoral, antiangiogenic and protective effect against malignant tumors.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Antitumoral pharmaceutical composition containing polypeptide fragments of serralysins |
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