AN IMPROVED PROCESS FOR LACTONIZATION IN THE PREPARATION OF STATINS

AN IMPROVED PROCESS FOR LACTONIZATION IN THE PREPARATION OF STATINS

The present invention relates to an improved and industrial friendly process for lactonization to produce compound of the Formula [I], from compound of the Formula [II] in presence of an inorganic compound as a suitable lactonizing agent, preferably alkali metal hydrogen sulfate, and crystallizing t...

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Hauptverfasser: PANCHASARA, DINESH R, THAPER, RAJESH KUMAR, BHADWAL, PARAMVIR, DUBEY, SUSHIL KUMAR, JAISWAL, SANJAY, KHANNA, JAG MOHAN, SINGH, GOVIND
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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creator PANCHASARA, DINESH R
THAPER, RAJESH KUMAR
BHADWAL, PARAMVIR
DUBEY, SUSHIL KUMAR
JAISWAL, SANJAY
KHANNA, JAG MOHAN
SINGH, GOVIND
description The present invention relates to an improved and industrial friendly process for lactonization to produce compound of the Formula [I], from compound of the Formula [II] in presence of an inorganic compound as a suitable lactonizing agent, preferably alkali metal hydrogen sulfate, and crystallizing the obtained lactone product in a solvent; or treating compound of the Formula [II] in the presence of an inorganic compound preferably alkali metal hydrogen sulfate using phase transfer catalyst in heterogeneous phase followed by crystallizing the obtained lactone product in a solvent.
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subjects ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
title AN IMPROVED PROCESS FOR LACTONIZATION IN THE PREPARATION OF STATINS
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