METHODS FOR DETERMINING CONFORMATIONAL CHANGES AND SELF-ASSEMBLY OF PROTEINS

METHODS FOR DETERMINING CONFORMATIONAL CHANGES AND SELF-ASSEMBLY OF PROTEINS

The invention relates to methods for measuring conformational changes and self-assembly/aggregation of proteins, especially the formation of amyloid fibrils, using conjugated polyelectrolytes. The conjugate polyelectrolyte is exposed to the protein whereby the conjugated polyelectrolyte and the prot...

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Hauptverfasser: HERLAND, ANNA, AASBERG, PETER, HAMMARSTROEM, PER, NILSSON, PETER, INGANAES, OLLE
Format: Patent
Sprache:eng ; fre ; ger
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INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
PHYSICS
TESTING
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creator HERLAND, ANNA
AASBERG, PETER
HAMMARSTROEM, PER
NILSSON, PETER
INGANAES, OLLE
description The invention relates to methods for measuring conformational changes and self-assembly/aggregation of proteins, especially the formation of amyloid fibrils, using conjugated polyelectrolytes. The conjugate polyelectrolyte is exposed to the protein whereby the conjugated polyelectrolyte and the protein of interest interact, and a change of a property of the polyelectrolyte in response to conformational changes of the protein is observed. The detected change is used to determine different conformations of the protein, especially the formation of amyloid fibrils.
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subjects INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
PHYSICS
TESTING
title METHODS FOR DETERMINING CONFORMATIONAL CHANGES AND SELF-ASSEMBLY OF PROTEINS
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