PYK2 INHIBITORS FOR STIMULATION OF OSTEOBLAST FUNCTION

PYK2 INHIBITORS FOR STIMULATION OF OSTEOBLAST FUNCTION

The present invention relates to methods of stimulating osteoblast function with a PYK2 inhibitor in subjects with osteoporosis, bone fractures, non-unions, pseudoarthroses, periodontal disease or other disorders of bone metabolism. Optionally, the method further comprises administration of a second...

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Hauptverfasser: LUZZIO, MICHAEL JOSEPH, OLSON, LISA MARIA, KATH, JOHN CHARLES, BROWN, THOMAS AQUINAS, BUCKBINDER, LEONARD, GUZMAN-PEREZ, ANGEL, KE, HUA ZHU
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Sprache:eng ; fre ; ger
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HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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creator LUZZIO, MICHAEL JOSEPH
OLSON, LISA MARIA
KATH, JOHN CHARLES
BROWN, THOMAS AQUINAS
BUCKBINDER, LEONARD
GUZMAN-PEREZ, ANGEL
KE, HUA ZHU
description The present invention relates to methods of stimulating osteoblast function with a PYK2 inhibitor in subjects with osteoporosis, bone fractures, non-unions, pseudoarthroses, periodontal disease or other disorders of bone metabolism. Optionally, the method further comprises administration of a second therapeutic bone agent. The present invention also relates to methods to identify a PYK2 inhibitor effective as a therapeutic bone agent comprising administering a test agent to an osteoblast-like cell and determining if osteoblast function is stimulated. Optionally, the identifying method further comprises contacting the test agent with PYK2 and determining if PYK2 activity is inhibited.
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subjects HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title PYK2 INHIBITORS FOR STIMULATION OF OSTEOBLAST FUNCTION
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