6,7,8,9-SUBSTITUTED 1-PHENYL-1,5-DIHYDRO-PYRIDO(3,2-B)INDOL-2-ONES USEFUL AS ANTI-INFECTIVE PHARMACEUTICAL AGENTS
This invention concerns the compounds the N-oxides, salts, stereoisomeric forms, racemic mixtures, prodrugs, esters and metabolites thereof, wherein X is NR2, O, S, SO, SO2; R1 is hydrogen, cyano, halo, substituted carbonyl, methanimidamidyl, N-hydroxy-methanimidamidyl, mono- or di(C1-4alkyl)methani...
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| creator | RABOISSON, PIERRE JEAN-MARIE, BERNARD PEETERS, ANNICK ANN WIGERINCK, PIET, TOM, BERT, PAUL SURLERAUX, DOMINIQUE, LOUIS, NESTOR, GHISLAIN KESTELEYN, BART, RUDOLF, ROMANIE VENDEVILLE, SANDRINE, MARIE, HELENE KINDERMANS, NATALIE, MARIA, FRANCISCA |
| description | This invention concerns the compounds the N-oxides, salts, stereoisomeric forms, racemic mixtures, prodrugs, esters and metabolites thereof, wherein X is NR2, O, S, SO, SO2; R1 is hydrogen, cyano, halo, substituted carbonyl, methanimidamidyl, N-hydroxy-methanimidamidyl, mono- or di(C1-4alkyl)methanimidamidyl, Het1 or Het2; n is 1, 2 or 3; R2 is hydrogen, aryl substituted with a radical -COOR4; or R2 is substituted C1-10alkyl, C2-10alkenyl or C3-7cycloalkyl; or R2 is a radical of formula: -CpH2p-CH(OR14)-CqH2q-R15 (b-3); -CH2-CH2-(O-CH2-CH2)m-OR14 (b-4); -CH2-CH2-(O-CH2-CH2)m-NR5aR5b(b-5) -a1=a2-a3=a4- is -CH-CH-CH-CH-; -N-CH-CH-CH-; -CH-N-CH-CH-; -CH-CH-N-CH-; -CH-CH-CH-N- (c-5); wherein one of the hydrogen atoms in (c-1)-(c-5) is replaced by particular radicals; R3 is nitro, cyano, amino, halo, hydroxy, C1-4alkyloxy, hydroxycarbonyl, substituted carbonyl, methanimidamidyl, mono- or di(C1-4alkyl)methanimidamidyl, N-hydroxy-methanimidamidyl or Het1. |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_EP1751156A1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>EP1751156A1</sourcerecordid><originalsourceid>FETCH-epo_espacenet_EP1751156A13</originalsourceid><addsrcrecordid>eNqNyjEOwiAUANAuDka9A6Mm_IGatjpS-BWSCqSASaemMTgZran3jw4ewOktb5m9SlrRAz2Cj7UPOsSAkjBwCk3fAqMFSK162Vlwfael3e5pDvVOG2lbyMEa9CR6bGJLuCfcBA3aNCiCviBxindnLjAGLfg3nNAEv84Wt_E-p83PVUYaDEJBmp5Dmqfxmh7pPaBjVcFYUXK2_6N8ANLZNn8</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>6,7,8,9-SUBSTITUTED 1-PHENYL-1,5-DIHYDRO-PYRIDO(3,2-B)INDOL-2-ONES USEFUL AS ANTI-INFECTIVE PHARMACEUTICAL AGENTS</title><source>esp@cenet</source><creator>RABOISSON, PIERRE JEAN-MARIE, BERNARD ; PEETERS, ANNICK ANN ; WIGERINCK, PIET, TOM, BERT, PAUL ; SURLERAUX, DOMINIQUE, LOUIS, NESTOR, GHISLAIN ; KESTELEYN, BART, RUDOLF, ROMANIE ; VENDEVILLE, SANDRINE, MARIE, HELENE ; KINDERMANS, NATALIE, MARIA, FRANCISCA</creator><creatorcontrib>RABOISSON, PIERRE JEAN-MARIE, BERNARD ; PEETERS, ANNICK ANN ; WIGERINCK, PIET, TOM, BERT, PAUL ; SURLERAUX, DOMINIQUE, LOUIS, NESTOR, GHISLAIN ; KESTELEYN, BART, RUDOLF, ROMANIE ; VENDEVILLE, SANDRINE, MARIE, HELENE ; KINDERMANS, NATALIE, MARIA, FRANCISCA</creatorcontrib><description>This invention concerns the compounds the N-oxides, salts, stereoisomeric forms, racemic mixtures, prodrugs, esters and metabolites thereof, wherein X is NR2, O, S, SO, SO2; R1 is hydrogen, cyano, halo, substituted carbonyl, methanimidamidyl, N-hydroxy-methanimidamidyl, mono- or di(C1-4alkyl)methanimidamidyl, Het1 or Het2; n is 1, 2 or 3; R2 is hydrogen, aryl substituted with a radical -COOR4; or R2 is substituted C1-10alkyl, C2-10alkenyl or C3-7cycloalkyl; or R2 is a radical of formula: -CpH2p-CH(OR14)-CqH2q-R15 (b-3); -CH2-CH2-(O-CH2-CH2)m-OR14 (b-4); -CH2-CH2-(O-CH2-CH2)m-NR5aR5b(b-5) -a1=a2-a3=a4- is -CH-CH-CH-CH-; -N-CH-CH-CH-; -CH-N-CH-CH-; -CH-CH-N-CH-; -CH-CH-CH-N- (c-5); wherein one of the hydrogen atoms in (c-1)-(c-5) is replaced by particular radicals; R3 is nitro, cyano, amino, halo, hydroxy, C1-4alkyloxy, hydroxycarbonyl, substituted carbonyl, methanimidamidyl, mono- or di(C1-4alkyl)methanimidamidyl, N-hydroxy-methanimidamidyl or Het1.</description><language>eng ; fre ; ger</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2007</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20070214&DB=EPODOC&CC=EP&NR=1751156A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25562,76317</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20070214&DB=EPODOC&CC=EP&NR=1751156A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>RABOISSON, PIERRE JEAN-MARIE, BERNARD</creatorcontrib><creatorcontrib>PEETERS, ANNICK ANN</creatorcontrib><creatorcontrib>WIGERINCK, PIET, TOM, BERT, PAUL</creatorcontrib><creatorcontrib>SURLERAUX, DOMINIQUE, LOUIS, NESTOR, GHISLAIN</creatorcontrib><creatorcontrib>KESTELEYN, BART, RUDOLF, ROMANIE</creatorcontrib><creatorcontrib>VENDEVILLE, SANDRINE, MARIE, HELENE</creatorcontrib><creatorcontrib>KINDERMANS, NATALIE, MARIA, FRANCISCA</creatorcontrib><title>6,7,8,9-SUBSTITUTED 1-PHENYL-1,5-DIHYDRO-PYRIDO(3,2-B)INDOL-2-ONES USEFUL AS ANTI-INFECTIVE PHARMACEUTICAL AGENTS</title><description>This invention concerns the compounds the N-oxides, salts, stereoisomeric forms, racemic mixtures, prodrugs, esters and metabolites thereof, wherein X is NR2, O, S, SO, SO2; R1 is hydrogen, cyano, halo, substituted carbonyl, methanimidamidyl, N-hydroxy-methanimidamidyl, mono- or di(C1-4alkyl)methanimidamidyl, Het1 or Het2; n is 1, 2 or 3; R2 is hydrogen, aryl substituted with a radical -COOR4; or R2 is substituted C1-10alkyl, C2-10alkenyl or C3-7cycloalkyl; or R2 is a radical of formula: -CpH2p-CH(OR14)-CqH2q-R15 (b-3); -CH2-CH2-(O-CH2-CH2)m-OR14 (b-4); -CH2-CH2-(O-CH2-CH2)m-NR5aR5b(b-5) -a1=a2-a3=a4- is -CH-CH-CH-CH-; -N-CH-CH-CH-; -CH-N-CH-CH-; -CH-CH-N-CH-; -CH-CH-CH-N- (c-5); wherein one of the hydrogen atoms in (c-1)-(c-5) is replaced by particular radicals; R3 is nitro, cyano, amino, halo, hydroxy, C1-4alkyloxy, hydroxycarbonyl, substituted carbonyl, methanimidamidyl, mono- or di(C1-4alkyl)methanimidamidyl, N-hydroxy-methanimidamidyl or Het1.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2007</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNyjEOwiAUANAuDka9A6Mm_IGatjpS-BWSCqSASaemMTgZran3jw4ewOktb5m9SlrRAz2Cj7UPOsSAkjBwCk3fAqMFSK162Vlwfael3e5pDvVOG2lbyMEa9CR6bGJLuCfcBA3aNCiCviBxindnLjAGLfg3nNAEv84Wt_E-p83PVUYaDEJBmp5Dmqfxmh7pPaBjVcFYUXK2_6N8ANLZNn8</recordid><startdate>20070214</startdate><enddate>20070214</enddate><creator>RABOISSON, PIERRE JEAN-MARIE, BERNARD</creator><creator>PEETERS, ANNICK ANN</creator><creator>WIGERINCK, PIET, TOM, BERT, PAUL</creator><creator>SURLERAUX, DOMINIQUE, LOUIS, NESTOR, GHISLAIN</creator><creator>KESTELEYN, BART, RUDOLF, ROMANIE</creator><creator>VENDEVILLE, SANDRINE, MARIE, HELENE</creator><creator>KINDERMANS, NATALIE, MARIA, FRANCISCA</creator><scope>EVB</scope></search><sort><creationdate>20070214</creationdate><title>6,7,8,9-SUBSTITUTED 1-PHENYL-1,5-DIHYDRO-PYRIDO(3,2-B)INDOL-2-ONES USEFUL AS ANTI-INFECTIVE PHARMACEUTICAL AGENTS</title><author>RABOISSON, PIERRE JEAN-MARIE, BERNARD ; PEETERS, ANNICK ANN ; WIGERINCK, PIET, TOM, BERT, PAUL ; SURLERAUX, DOMINIQUE, LOUIS, NESTOR, GHISLAIN ; KESTELEYN, BART, RUDOLF, ROMANIE ; VENDEVILLE, SANDRINE, MARIE, HELENE ; KINDERMANS, NATALIE, MARIA, FRANCISCA</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_EP1751156A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre ; ger</language><creationdate>2007</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>RABOISSON, PIERRE JEAN-MARIE, BERNARD</creatorcontrib><creatorcontrib>PEETERS, ANNICK ANN</creatorcontrib><creatorcontrib>WIGERINCK, PIET, TOM, BERT, PAUL</creatorcontrib><creatorcontrib>SURLERAUX, DOMINIQUE, LOUIS, NESTOR, GHISLAIN</creatorcontrib><creatorcontrib>KESTELEYN, BART, RUDOLF, ROMANIE</creatorcontrib><creatorcontrib>VENDEVILLE, SANDRINE, MARIE, HELENE</creatorcontrib><creatorcontrib>KINDERMANS, NATALIE, MARIA, FRANCISCA</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>RABOISSON, PIERRE JEAN-MARIE, BERNARD</au><au>PEETERS, ANNICK ANN</au><au>WIGERINCK, PIET, TOM, BERT, PAUL</au><au>SURLERAUX, DOMINIQUE, LOUIS, NESTOR, GHISLAIN</au><au>KESTELEYN, BART, RUDOLF, ROMANIE</au><au>VENDEVILLE, SANDRINE, MARIE, HELENE</au><au>KINDERMANS, NATALIE, MARIA, FRANCISCA</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>6,7,8,9-SUBSTITUTED 1-PHENYL-1,5-DIHYDRO-PYRIDO(3,2-B)INDOL-2-ONES USEFUL AS ANTI-INFECTIVE PHARMACEUTICAL AGENTS</title><date>2007-02-14</date><risdate>2007</risdate><abstract>This invention concerns the compounds the N-oxides, salts, stereoisomeric forms, racemic mixtures, prodrugs, esters and metabolites thereof, wherein X is NR2, O, S, SO, SO2; R1 is hydrogen, cyano, halo, substituted carbonyl, methanimidamidyl, N-hydroxy-methanimidamidyl, mono- or di(C1-4alkyl)methanimidamidyl, Het1 or Het2; n is 1, 2 or 3; R2 is hydrogen, aryl substituted with a radical -COOR4; or R2 is substituted C1-10alkyl, C2-10alkenyl or C3-7cycloalkyl; or R2 is a radical of formula: -CpH2p-CH(OR14)-CqH2q-R15 (b-3); -CH2-CH2-(O-CH2-CH2)m-OR14 (b-4); -CH2-CH2-(O-CH2-CH2)m-NR5aR5b(b-5) -a1=a2-a3=a4- is -CH-CH-CH-CH-; -N-CH-CH-CH-; -CH-N-CH-CH-; -CH-CH-N-CH-; -CH-CH-CH-N- (c-5); wherein one of the hydrogen atoms in (c-1)-(c-5) is replaced by particular radicals; R3 is nitro, cyano, amino, halo, hydroxy, C1-4alkyloxy, hydroxycarbonyl, substituted carbonyl, methanimidamidyl, mono- or di(C1-4alkyl)methanimidamidyl, N-hydroxy-methanimidamidyl or Het1.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | 6,7,8,9-SUBSTITUTED 1-PHENYL-1,5-DIHYDRO-PYRIDO(3,2-B)INDOL-2-ONES USEFUL AS ANTI-INFECTIVE PHARMACEUTICAL AGENTS |
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