NITROGENATED HETEROCYCLIC DERIVATIVES AS PROTEIN KINASE MODULATORS AND USE FOR THE TREATMENT OF ANGIOGENESIS AND CANCER
The present invention relates to chemical compounds having a general formula I wherein A, B, D, E, G, H1-5 and R1-4 are defined herein, and synthetic intermediates, which are capable of modulating various protein kinase receptor enzymes and, thereby, influencing various disease states and conditions...
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| creator | TEMPEST, PAUL, A ALBRECHT, BRIAN, K NGUYEN, HANH, NHO HODOUS, BRIAN, L BELLON, STEVEN CHAFFEE, STUART, C JOHNSON, REBECCA, E CEE, VICTOR, J OLIVIERI, PHILIP, R CHENG, YUAN XI, NING ROMERO, KARINA GEUNS-MEYER, STEPHANIE, D ZHU, XIAOTIAN KIM, JOSEPH, L PATEL, VINOD, F DEAK, HOLLY, L |
| description | The present invention relates to chemical compounds having a general formula I wherein A, B, D, E, G, H1-5 and R1-4 are defined herein, and synthetic intermediates, which are capable of modulating various protein kinase receptor enzymes and, thereby, influencing various disease states and conditions related to the activities of these kinases. For example, the compounds are capable of modulating kinase enzymes thereby influencing the process of angiogenesis and treating angiogenesis-related diseases and other poliferative disorders, including cancer and inflammation. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of protein kinases. |
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For example, the compounds are capable of modulating kinase enzymes thereby influencing the process of angiogenesis and treating angiogenesis-related diseases and other poliferative disorders, including cancer and inflammation. 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For example, the compounds are capable of modulating kinase enzymes thereby influencing the process of angiogenesis and treating angiogenesis-related diseases and other poliferative disorders, including cancer and inflammation. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of protein kinases.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2014</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNjEEKwjAQRbtxIeod5gIuQlHXMZk2g21SJtOCq1IkrkQLFby-FT2Aqw_vPf4ye3kSDiV6LWjBoSAHczYVGbDI1GmhDiPoCA0HQfJwIq8jQh1sW2kJPEtvoZ1RERjEIQijlhq9QChmWdLnHyN9S6O9QV5ni-twm9Lmt6sMChTjtml89Gkah0u6p2ePjTrslMr3R5X_kbwBFpo5Zg</recordid><startdate>20140702</startdate><enddate>20140702</enddate><creator>TEMPEST, PAUL, A</creator><creator>ALBRECHT, BRIAN, K</creator><creator>NGUYEN, HANH, NHO</creator><creator>HODOUS, BRIAN, L</creator><creator>BELLON, STEVEN</creator><creator>CHAFFEE, STUART, C</creator><creator>JOHNSON, REBECCA, E</creator><creator>CEE, VICTOR, J</creator><creator>OLIVIERI, PHILIP, R</creator><creator>CHENG, YUAN</creator><creator>XI, NING</creator><creator>ROMERO, KARINA</creator><creator>GEUNS-MEYER, STEPHANIE, D</creator><creator>ZHU, XIAOTIAN</creator><creator>KIM, JOSEPH, L</creator><creator>PATEL, VINOD, F</creator><creator>DEAK, HOLLY, L</creator><scope>EVB</scope></search><sort><creationdate>20140702</creationdate><title>NITROGENATED HETEROCYCLIC DERIVATIVES AS PROTEIN KINASE MODULATORS AND USE FOR THE TREATMENT OF ANGIOGENESIS AND CANCER</title><author>TEMPEST, PAUL, A ; ALBRECHT, BRIAN, K ; NGUYEN, HANH, NHO ; HODOUS, BRIAN, L ; BELLON, STEVEN ; CHAFFEE, STUART, C ; JOHNSON, REBECCA, E ; CEE, VICTOR, J ; OLIVIERI, PHILIP, R ; CHENG, YUAN ; XI, NING ; ROMERO, KARINA ; GEUNS-MEYER, STEPHANIE, D ; ZHU, XIAOTIAN ; KIM, JOSEPH, L ; PATEL, VINOD, F ; DEAK, HOLLY, L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_EP1751136B13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre ; ger</language><creationdate>2014</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><toplevel>online_resources</toplevel><creatorcontrib>TEMPEST, PAUL, A</creatorcontrib><creatorcontrib>ALBRECHT, BRIAN, K</creatorcontrib><creatorcontrib>NGUYEN, HANH, NHO</creatorcontrib><creatorcontrib>HODOUS, BRIAN, L</creatorcontrib><creatorcontrib>BELLON, STEVEN</creatorcontrib><creatorcontrib>CHAFFEE, STUART, C</creatorcontrib><creatorcontrib>JOHNSON, REBECCA, E</creatorcontrib><creatorcontrib>CEE, VICTOR, J</creatorcontrib><creatorcontrib>OLIVIERI, PHILIP, R</creatorcontrib><creatorcontrib>CHENG, YUAN</creatorcontrib><creatorcontrib>XI, NING</creatorcontrib><creatorcontrib>ROMERO, KARINA</creatorcontrib><creatorcontrib>GEUNS-MEYER, STEPHANIE, D</creatorcontrib><creatorcontrib>ZHU, XIAOTIAN</creatorcontrib><creatorcontrib>KIM, JOSEPH, L</creatorcontrib><creatorcontrib>PATEL, VINOD, F</creatorcontrib><creatorcontrib>DEAK, HOLLY, L</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>TEMPEST, PAUL, A</au><au>ALBRECHT, BRIAN, K</au><au>NGUYEN, HANH, NHO</au><au>HODOUS, BRIAN, L</au><au>BELLON, STEVEN</au><au>CHAFFEE, STUART, C</au><au>JOHNSON, REBECCA, E</au><au>CEE, VICTOR, J</au><au>OLIVIERI, PHILIP, R</au><au>CHENG, YUAN</au><au>XI, NING</au><au>ROMERO, KARINA</au><au>GEUNS-MEYER, STEPHANIE, D</au><au>ZHU, XIAOTIAN</au><au>KIM, JOSEPH, L</au><au>PATEL, VINOD, F</au><au>DEAK, HOLLY, L</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>NITROGENATED HETEROCYCLIC DERIVATIVES AS PROTEIN KINASE MODULATORS AND USE FOR THE TREATMENT OF ANGIOGENESIS AND CANCER</title><date>2014-07-02</date><risdate>2014</risdate><abstract>The present invention relates to chemical compounds having a general formula I wherein A, B, D, E, G, H1-5 and R1-4 are defined herein, and synthetic intermediates, which are capable of modulating various protein kinase receptor enzymes and, thereby, influencing various disease states and conditions related to the activities of these kinases. For example, the compounds are capable of modulating kinase enzymes thereby influencing the process of angiogenesis and treating angiogenesis-related diseases and other poliferative disorders, including cancer and inflammation. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of protein kinases.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES |
| title | NITROGENATED HETEROCYCLIC DERIVATIVES AS PROTEIN KINASE MODULATORS AND USE FOR THE TREATMENT OF ANGIOGENESIS AND CANCER |
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