KINASE MODULATORS AND METHODS OF USE
The present invention relates to compounds of the Formula (I) and (II) wherein R, R21, R25-R33, m, n, X21-X23, and Q1 are defined herein. The compounds modulate protein kinase enzymatic activity to modulate cellular activities such as proliferation, differentiation, programmed cell death, migration...
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| creator | KLEIN, RHETT, RONALD BOWLES, OWEN, JOSEPH BUSSENIUS, JOERG FRANZINI, MAURIZIO BLAZEY, CHARLES, M CANNE BANNEN, LYNNE JAMMALAMADAKA, VASU DUBENKO, LARISA COSTANZO, SIMONA MAC, MORRISON, B HUANG, PING PARKS, JASON, JEVIOUS CHAN, DIVA SZE-MING KIM, MOON, HWAN LE, DONNA, TRA CO, ERICK WANG ANAND, NEEL, K DEFINA, STEVEN, CHARLES CHEN, BAILI KHOURY, RICHARD GEORGE |
| description | The present invention relates to compounds of the Formula (I) and (II) wherein R, R21, R25-R33, m, n, X21-X23, and Q1 are defined herein. The compounds modulate protein kinase enzymatic activity to modulate cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Compounds of the invention inhibit, regulate and/or modulate kinases, particularly p70S6 and/or Akt kinases. Methods of using and preparing the compounds, and pharmaceutical compositions thereof, to treat kinase-dependent diseases and conditions are also an aspect of the invention. |
| format | Patent |
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The compounds modulate protein kinase enzymatic activity to modulate cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Compounds of the invention inhibit, regulate and/or modulate kinases, particularly p70S6 and/or Akt kinases. Methods of using and preparing the compounds, and pharmaceutical compositions thereof, to treat kinase-dependent diseases and conditions are also an aspect of the invention.</description><language>eng ; fre ; ger</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><creationdate>2007</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20070214&DB=EPODOC&CC=EP&NR=1750727A2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25563,76418</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20070214&DB=EPODOC&CC=EP&NR=1750727A2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>KLEIN, RHETT, RONALD</creatorcontrib><creatorcontrib>BOWLES, OWEN, JOSEPH</creatorcontrib><creatorcontrib>BUSSENIUS, JOERG</creatorcontrib><creatorcontrib>FRANZINI, MAURIZIO</creatorcontrib><creatorcontrib>BLAZEY, CHARLES, M</creatorcontrib><creatorcontrib>CANNE BANNEN, LYNNE</creatorcontrib><creatorcontrib>JAMMALAMADAKA, VASU</creatorcontrib><creatorcontrib>DUBENKO, LARISA</creatorcontrib><creatorcontrib>COSTANZO, SIMONA</creatorcontrib><creatorcontrib>MAC, MORRISON, B</creatorcontrib><creatorcontrib>HUANG, PING</creatorcontrib><creatorcontrib>PARKS, JASON, JEVIOUS</creatorcontrib><creatorcontrib>CHAN, DIVA SZE-MING</creatorcontrib><creatorcontrib>KIM, MOON, HWAN</creatorcontrib><creatorcontrib>LE, DONNA, TRA</creatorcontrib><creatorcontrib>CO, ERICK WANG</creatorcontrib><creatorcontrib>ANAND, NEEL, K</creatorcontrib><creatorcontrib>DEFINA, STEVEN, CHARLES</creatorcontrib><creatorcontrib>CHEN, BAILI</creatorcontrib><creatorcontrib>KHOURY, RICHARD GEORGE</creatorcontrib><title>KINASE MODULATORS AND METHODS OF USE</title><description>The present invention relates to compounds of the Formula (I) and (II) wherein R, R21, R25-R33, m, n, X21-X23, and Q1 are defined herein. The compounds modulate protein kinase enzymatic activity to modulate cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Compounds of the invention inhibit, regulate and/or modulate kinases, particularly p70S6 and/or Akt kinases. Methods of using and preparing the compounds, and pharmaceutical compositions thereof, to treat kinase-dependent diseases and conditions are also an aspect of the invention.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2007</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZFDx9vRzDHZV8PV3CfVxDPEPClZw9HNR8HUN8fB3CVbwd1MIDXblYWBNS8wpTuWF0twMCm6uIc4euqkF-fGpxQWJyal5qSXxrgGG5qYG5kbmjkbGRCgBAC8ZIn0</recordid><startdate>20070214</startdate><enddate>20070214</enddate><creator>KLEIN, RHETT, RONALD</creator><creator>BOWLES, OWEN, JOSEPH</creator><creator>BUSSENIUS, JOERG</creator><creator>FRANZINI, MAURIZIO</creator><creator>BLAZEY, CHARLES, M</creator><creator>CANNE BANNEN, LYNNE</creator><creator>JAMMALAMADAKA, VASU</creator><creator>DUBENKO, LARISA</creator><creator>COSTANZO, SIMONA</creator><creator>MAC, MORRISON, B</creator><creator>HUANG, PING</creator><creator>PARKS, JASON, JEVIOUS</creator><creator>CHAN, DIVA SZE-MING</creator><creator>KIM, MOON, HWAN</creator><creator>LE, DONNA, TRA</creator><creator>CO, ERICK WANG</creator><creator>ANAND, NEEL, K</creator><creator>DEFINA, STEVEN, CHARLES</creator><creator>CHEN, BAILI</creator><creator>KHOURY, RICHARD GEORGE</creator><scope>EVB</scope></search><sort><creationdate>20070214</creationdate><title>KINASE MODULATORS AND METHODS OF USE</title><author>KLEIN, RHETT, RONALD ; BOWLES, OWEN, JOSEPH ; BUSSENIUS, JOERG ; FRANZINI, MAURIZIO ; BLAZEY, CHARLES, M ; CANNE BANNEN, LYNNE ; JAMMALAMADAKA, VASU ; DUBENKO, LARISA ; COSTANZO, SIMONA ; MAC, MORRISON, B ; HUANG, PING ; PARKS, JASON, JEVIOUS ; CHAN, DIVA SZE-MING ; KIM, MOON, HWAN ; LE, DONNA, TRA ; CO, ERICK WANG ; ANAND, NEEL, K ; DEFINA, STEVEN, CHARLES ; CHEN, BAILI ; KHOURY, RICHARD GEORGE</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_EP1750727A23</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre ; ger</language><creationdate>2007</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><toplevel>online_resources</toplevel><creatorcontrib>KLEIN, RHETT, RONALD</creatorcontrib><creatorcontrib>BOWLES, OWEN, JOSEPH</creatorcontrib><creatorcontrib>BUSSENIUS, JOERG</creatorcontrib><creatorcontrib>FRANZINI, MAURIZIO</creatorcontrib><creatorcontrib>BLAZEY, CHARLES, M</creatorcontrib><creatorcontrib>CANNE BANNEN, LYNNE</creatorcontrib><creatorcontrib>JAMMALAMADAKA, VASU</creatorcontrib><creatorcontrib>DUBENKO, LARISA</creatorcontrib><creatorcontrib>COSTANZO, SIMONA</creatorcontrib><creatorcontrib>MAC, MORRISON, B</creatorcontrib><creatorcontrib>HUANG, PING</creatorcontrib><creatorcontrib>PARKS, JASON, JEVIOUS</creatorcontrib><creatorcontrib>CHAN, DIVA SZE-MING</creatorcontrib><creatorcontrib>KIM, MOON, HWAN</creatorcontrib><creatorcontrib>LE, DONNA, TRA</creatorcontrib><creatorcontrib>CO, ERICK WANG</creatorcontrib><creatorcontrib>ANAND, NEEL, K</creatorcontrib><creatorcontrib>DEFINA, STEVEN, CHARLES</creatorcontrib><creatorcontrib>CHEN, BAILI</creatorcontrib><creatorcontrib>KHOURY, RICHARD GEORGE</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>KLEIN, RHETT, RONALD</au><au>BOWLES, OWEN, JOSEPH</au><au>BUSSENIUS, JOERG</au><au>FRANZINI, MAURIZIO</au><au>BLAZEY, CHARLES, M</au><au>CANNE BANNEN, LYNNE</au><au>JAMMALAMADAKA, VASU</au><au>DUBENKO, LARISA</au><au>COSTANZO, SIMONA</au><au>MAC, MORRISON, B</au><au>HUANG, PING</au><au>PARKS, JASON, JEVIOUS</au><au>CHAN, DIVA SZE-MING</au><au>KIM, MOON, HWAN</au><au>LE, DONNA, TRA</au><au>CO, ERICK WANG</au><au>ANAND, NEEL, K</au><au>DEFINA, STEVEN, CHARLES</au><au>CHEN, BAILI</au><au>KHOURY, RICHARD GEORGE</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>KINASE MODULATORS AND METHODS OF USE</title><date>2007-02-14</date><risdate>2007</risdate><abstract>The present invention relates to compounds of the Formula (I) and (II) wherein R, R21, R25-R33, m, n, X21-X23, and Q1 are defined herein. The compounds modulate protein kinase enzymatic activity to modulate cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Compounds of the invention inhibit, regulate and/or modulate kinases, particularly p70S6 and/or Akt kinases. Methods of using and preparing the compounds, and pharmaceutical compositions thereof, to treat kinase-dependent diseases and conditions are also an aspect of the invention.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES |
| title | KINASE MODULATORS AND METHODS OF USE |
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