SURROGATE MARKERS OF NEUROPATHIC PAIN

The disclosure provides methods and compositions for the evaluation of neuropathic pain and neurotrophic or other activity of a drug or drug candidate. In the disclosed methods, expression of certain gene(s) in tissue extracts from skin biopsies serves as a proxy of a relevant endpoint.

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Bibliographische Detailangaben
Hauptverfasser: SAH, DINAH, W., Y, BANDARU, RJASEKHAR, SZAK, SUZANNE, CATE, RICHARD, EHRENFELS, CHRISTIAN, W
Format: Patent
Sprache:eng ; fre ; ger
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Beschreibung
Zusammenfassung:The disclosure provides methods and compositions for the evaluation of neuropathic pain and neurotrophic or other activity of a drug or drug candidate. In the disclosed methods, expression of certain gene(s) in tissue extracts from skin biopsies serves as a proxy of a relevant endpoint.