Method for detecting the presence of a residue analyte in a sample

Method for detecting the presence of a residue analyte in a sample

A method for the detection of an analyte in a liquid sample comprises employing a labelled receptor that reacts with the analyte to form an analyte-receptor complex, positioning the labelled receptor within or proximate to a membrane, exposing said membrane to the liquid sample whereby lateral capil...

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Hauptverfasser: FRANCISCO, CHERYL A, AGI-GLICKMAN, YAEL, MARKOVSKY, ROBERT J, CHARM, STANLEY E, SAUL, STEVEN J, SKIFFINGTON, RICHARD T, ZOMER, ELIEZER, DONAHUE, PAUL R, TRIVEDI, SHIFALI B, SCHEEMAKER, JOAN L
Format: Patent
Sprache:eng ; fre ; ger
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INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
PHYSICS
TESTING
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creator FRANCISCO, CHERYL A
AGI-GLICKMAN, YAEL
MARKOVSKY, ROBERT J
CHARM, STANLEY E
SAUL, STEVEN J
SKIFFINGTON, RICHARD T
ZOMER, ELIEZER
DONAHUE, PAUL R
TRIVEDI, SHIFALI B
SCHEEMAKER, JOAN L
description A method for the detection of an analyte in a liquid sample comprises employing a labelled receptor that reacts with the analyte to form an analyte-receptor complex, positioning the labelled receptor within or proximate to a membrane, exposing said membrane to the liquid sample whereby lateral capillary flow occurs thereon, the liquid thereby carrying the analyte-receptor complex and any unbound labelled receptor towards a test zone positioned on the membrane in the flow path, said test zone having a representative analyte conjugate attached to the membrane to bind unbound receptor to form a first analyte conjugate receptor complex that as a result of the label has a signal visible to the eye or readable with an instrument where the receptor may bind a family of analytes which have similar structural binding sites and the method includes the step of employing additional analyte binders that bind a portion of the analyte in competition with the receptor thereby decreasing test sensitivity.
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subjects INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
PHYSICS
TESTING
title Method for detecting the presence of a residue analyte in a sample
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