PHARMACEUTICALLY ACTIVE 4,6-DISUBSTITUTED AMINOPYRIMIDINE DERIVATIVES AS MODULATORS OF PROTEIN KINASES
The present invention relates to 4,6-disubstituted aminopyrimidine derivatives and/or pharmaceutically acceptable salts thereof, the use of these derivatives as pharmaceutically active agents, especially for the prophylaxis and/or treatment of infectious diseases, including opportunistic diseases, p...
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| creator | BRAVO, JOSE HERGET, THOMAS FREISLEBEN, ACHIM CHOIDAS, AXEL HARRIS, JOHN HARTUNG, CHRISTIAN MUELLER, GERHARD MISSIO, ANDREA COTTEN, MATT ENGKVIST, OLA FELBER, BEATRICE KLEBL, BERT HABENBERGER, PETER ZECH, BIRGIT GODL, KLAUS HOPPE, EDMUND BACKES, ALEXANDER GREFF, ZOLTAN SCHWAB, WILFRIED HAFENBRADL, DORIS |
| description | The present invention relates to 4,6-disubstituted aminopyrimidine derivatives and/or pharmaceutically acceptable salts thereof, the use of these derivatives as pharmaceutically active agents, especially for the prophylaxis and/or treatment of infectious diseases, including opportunistic diseases, prion diseases, immunological diseases, autoimmune diseases, bipolar and clinical disorders, cardiovascular diseases, cell proliferative diseases, diabetes, inflammation, transplant rejections, erectile dysfunction, neurodegenerative diseases and stroke, and pharmaceutical compositions containing at least one of said 4,6-di substituted aminopyrimidine derivatives and/or pharmaceutically acceptable salts thereof. Furthermore, the present invention relates to the use of said 4,6-disubstituted aminopyrimidine derivatives as inhibitors for a protein kinase and a medium comprising at least one of said 4,6-disubstituted aminopyrimidine derivatives in an immobilized form and the use of said medium for enriching, purifying and/or depleting nucleotide binding proteins which bind to the immobilized 4,6-disubstituted aminopyrimidine derivatives. |
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Furthermore, the present invention relates to the use of said 4,6-disubstituted aminopyrimidine derivatives as inhibitors for a protein kinase and a medium comprising at least one of said 4,6-disubstituted aminopyrimidine derivatives in an immobilized form and the use of said medium for enriching, purifying and/or depleting nucleotide binding proteins which bind to the immobilized 4,6-disubstituted aminopyrimidine derivatives.</description><language>eng ; fre ; ger</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><creationdate>2012</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20120808&DB=EPODOC&CC=EP&NR=1678147B1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76516</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20120808&DB=EPODOC&CC=EP&NR=1678147B1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>BRAVO, JOSE</creatorcontrib><creatorcontrib>HERGET, THOMAS</creatorcontrib><creatorcontrib>FREISLEBEN, ACHIM</creatorcontrib><creatorcontrib>CHOIDAS, AXEL</creatorcontrib><creatorcontrib>HARRIS, JOHN</creatorcontrib><creatorcontrib>HARTUNG, CHRISTIAN</creatorcontrib><creatorcontrib>MUELLER, GERHARD</creatorcontrib><creatorcontrib>MISSIO, ANDREA</creatorcontrib><creatorcontrib>COTTEN, MATT</creatorcontrib><creatorcontrib>ENGKVIST, OLA</creatorcontrib><creatorcontrib>FELBER, BEATRICE</creatorcontrib><creatorcontrib>KLEBL, BERT</creatorcontrib><creatorcontrib>HABENBERGER, PETER</creatorcontrib><creatorcontrib>ZECH, BIRGIT</creatorcontrib><creatorcontrib>GODL, KLAUS</creatorcontrib><creatorcontrib>HOPPE, EDMUND</creatorcontrib><creatorcontrib>BACKES, ALEXANDER</creatorcontrib><creatorcontrib>GREFF, ZOLTAN</creatorcontrib><creatorcontrib>SCHWAB, WILFRIED</creatorcontrib><creatorcontrib>HAFENBRADL, DORIS</creatorcontrib><title>PHARMACEUTICALLY ACTIVE 4,6-DISUBSTITUTED AMINOPYRIMIDINE DERIVATIVES AS MODULATORS OF PROTEIN KINASES</title><description>The present invention relates to 4,6-disubstituted aminopyrimidine derivatives and/or pharmaceutically acceptable salts thereof, the use of these derivatives as pharmaceutically active agents, especially for the prophylaxis and/or treatment of infectious diseases, including opportunistic diseases, prion diseases, immunological diseases, autoimmune diseases, bipolar and clinical disorders, cardiovascular diseases, cell proliferative diseases, diabetes, inflammation, transplant rejections, erectile dysfunction, neurodegenerative diseases and stroke, and pharmaceutical compositions containing at least one of said 4,6-di substituted aminopyrimidine derivatives and/or pharmaceutically acceptable salts thereof. Furthermore, the present invention relates to the use of said 4,6-disubstituted aminopyrimidine derivatives as inhibitors for a protein kinase and a medium comprising at least one of said 4,6-disubstituted aminopyrimidine derivatives in an immobilized form and the use of said medium for enriching, purifying and/or depleting nucleotide binding proteins which bind to the immobilized 4,6-disubstituted aminopyrimidine derivatives.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2012</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNyssKgkAUAFA3LaL6h_sBuZBE215nrnjJeTAPwZVIjKsowf6fCPqAVmdz9tliO3QKBcXAAvt-BBSBB4LyXOWSfWx84BADSUDF2tjRsWLJmkCS4wG_2QN6UEbGHoNxHkwL1plArOHGGj35Y7Zb5seWTj8PGbQURJen9TWlbZ3v6ZneE9miqq9FWTfF5Y_yAZkONUU</recordid><startdate>20120808</startdate><enddate>20120808</enddate><creator>BRAVO, JOSE</creator><creator>HERGET, THOMAS</creator><creator>FREISLEBEN, ACHIM</creator><creator>CHOIDAS, AXEL</creator><creator>HARRIS, JOHN</creator><creator>HARTUNG, CHRISTIAN</creator><creator>MUELLER, GERHARD</creator><creator>MISSIO, ANDREA</creator><creator>COTTEN, MATT</creator><creator>ENGKVIST, OLA</creator><creator>FELBER, BEATRICE</creator><creator>KLEBL, BERT</creator><creator>HABENBERGER, PETER</creator><creator>ZECH, BIRGIT</creator><creator>GODL, KLAUS</creator><creator>HOPPE, EDMUND</creator><creator>BACKES, ALEXANDER</creator><creator>GREFF, ZOLTAN</creator><creator>SCHWAB, WILFRIED</creator><creator>HAFENBRADL, DORIS</creator><scope>EVB</scope></search><sort><creationdate>20120808</creationdate><title>PHARMACEUTICALLY ACTIVE 4,6-DISUBSTITUTED AMINOPYRIMIDINE DERIVATIVES AS MODULATORS OF PROTEIN KINASES</title><author>BRAVO, JOSE ; 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Furthermore, the present invention relates to the use of said 4,6-disubstituted aminopyrimidine derivatives as inhibitors for a protein kinase and a medium comprising at least one of said 4,6-disubstituted aminopyrimidine derivatives in an immobilized form and the use of said medium for enriching, purifying and/or depleting nucleotide binding proteins which bind to the immobilized 4,6-disubstituted aminopyrimidine derivatives.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES |
| title | PHARMACEUTICALLY ACTIVE 4,6-DISUBSTITUTED AMINOPYRIMIDINE DERIVATIVES AS MODULATORS OF PROTEIN KINASES |
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