CHEMOKINE RECEPTOR ANTAGONIST AND MEDICAL USE THEREOF
The present invention relates to a compound represented by formula (I), a salt thereof, an N-oxide thereof, a solvate thereof or a prodrug thereof, and medical use thereof (the symbols in the formula are as described in the specification). The compound represented by formula (I) has chemokine recept...
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| creator | HABASHITA, HIROMU TAKEDA, KAZUHIKO WATANABE, NORIKI SHIBAYAMA, SHIRO OCHIAI, HIROSHI TOKUDA, NATSUKO KOMIYA, TAKAKI |
| description | The present invention relates to a compound represented by formula (I), a salt thereof, an N-oxide thereof, a solvate thereof or a prodrug thereof, and medical use thereof (the symbols in the formula are as described in the specification).
The compound represented by formula (I) has chemokine receptor (especially in CCR4 and/or CCR5) antagonistic activity. Therefore it is useful for prevention and/or treatment of a chemokine receptor-mediated disease such as inflammatory and/or allergic diseases [systemic inflammatory response syndrome (SIRS), anaphylaxis, anaphylactoid reaction, allergic angiitis, transplant rejection reaction, hepatitis, nephritis, nephropathy, pancreatitis, rhinitis, arthritis, inflammatory ocular disease, inflammatory bowel disease, disease in cerebro and/or circulatory system, respiratory disease, dermatosis, autoimmune disease, and the like], infection [viral disease (human immunodeficiency virus infection, acquired immunodeficiency syndrome, SARS, etc .), and the like], and the like. |
| format | Patent |
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The compound represented by formula (I) has chemokine receptor (especially in CCR4 and/or CCR5) antagonistic activity. Therefore it is useful for prevention and/or treatment of a chemokine receptor-mediated disease such as inflammatory and/or allergic diseases [systemic inflammatory response syndrome (SIRS), anaphylaxis, anaphylactoid reaction, allergic angiitis, transplant rejection reaction, hepatitis, nephritis, nephropathy, pancreatitis, rhinitis, arthritis, inflammatory ocular disease, inflammatory bowel disease, disease in cerebro and/or circulatory system, respiratory disease, dermatosis, autoimmune disease, and the like], infection [viral disease (human immunodeficiency virus infection, acquired immunodeficiency syndrome, SARS, etc .), and the like], and the like.</description><edition>7</edition><language>eng ; fre ; ger</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2006</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20060531&DB=EPODOC&CC=EP&NR=1661889A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20060531&DB=EPODOC&CC=EP&NR=1661889A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>HABASHITA, HIROMU</creatorcontrib><creatorcontrib>TAKEDA, KAZUHIKO</creatorcontrib><creatorcontrib>WATANABE, NORIKI</creatorcontrib><creatorcontrib>SHIBAYAMA, SHIRO</creatorcontrib><creatorcontrib>OCHIAI, HIROSHI</creatorcontrib><creatorcontrib>TOKUDA, NATSUKO</creatorcontrib><creatorcontrib>KOMIYA, TAKAKI</creatorcontrib><title>CHEMOKINE RECEPTOR ANTAGONIST AND MEDICAL USE THEREOF</title><description>The present invention relates to a compound represented by formula (I), a salt thereof, an N-oxide thereof, a solvate thereof or a prodrug thereof, and medical use thereof (the symbols in the formula are as described in the specification).
The compound represented by formula (I) has chemokine receptor (especially in CCR4 and/or CCR5) antagonistic activity. Therefore it is useful for prevention and/or treatment of a chemokine receptor-mediated disease such as inflammatory and/or allergic diseases [systemic inflammatory response syndrome (SIRS), anaphylaxis, anaphylactoid reaction, allergic angiitis, transplant rejection reaction, hepatitis, nephritis, nephropathy, pancreatitis, rhinitis, arthritis, inflammatory ocular disease, inflammatory bowel disease, disease in cerebro and/or circulatory system, respiratory disease, dermatosis, autoimmune disease, and the like], infection [viral disease (human immunodeficiency virus infection, acquired immunodeficiency syndrome, SARS, etc .), and the like], and the like.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2006</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZDB19nD19ff29HNVCHJ1dg0I8Q9ScPQLcXT39_MMDgEyXRR8XV08nR19FEKDXRVCPFyDXP3deBhY0xJzilN5oTQ3g4Kba4izh25qQX58anFBYnJqXmpJvGuAoZmZoYWFpaOhMRFKAJpkJz0</recordid><startdate>20060531</startdate><enddate>20060531</enddate><creator>HABASHITA, HIROMU</creator><creator>TAKEDA, KAZUHIKO</creator><creator>WATANABE, NORIKI</creator><creator>SHIBAYAMA, SHIRO</creator><creator>OCHIAI, HIROSHI</creator><creator>TOKUDA, NATSUKO</creator><creator>KOMIYA, TAKAKI</creator><scope>EVB</scope></search><sort><creationdate>20060531</creationdate><title>CHEMOKINE RECEPTOR ANTAGONIST AND MEDICAL USE THEREOF</title><author>HABASHITA, HIROMU ; TAKEDA, KAZUHIKO ; WATANABE, NORIKI ; SHIBAYAMA, SHIRO ; OCHIAI, HIROSHI ; TOKUDA, NATSUKO ; KOMIYA, TAKAKI</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_EP1661889A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre ; ger</language><creationdate>2006</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>HABASHITA, HIROMU</creatorcontrib><creatorcontrib>TAKEDA, KAZUHIKO</creatorcontrib><creatorcontrib>WATANABE, NORIKI</creatorcontrib><creatorcontrib>SHIBAYAMA, SHIRO</creatorcontrib><creatorcontrib>OCHIAI, HIROSHI</creatorcontrib><creatorcontrib>TOKUDA, NATSUKO</creatorcontrib><creatorcontrib>KOMIYA, TAKAKI</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>HABASHITA, HIROMU</au><au>TAKEDA, KAZUHIKO</au><au>WATANABE, NORIKI</au><au>SHIBAYAMA, SHIRO</au><au>OCHIAI, HIROSHI</au><au>TOKUDA, NATSUKO</au><au>KOMIYA, TAKAKI</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>CHEMOKINE RECEPTOR ANTAGONIST AND MEDICAL USE THEREOF</title><date>2006-05-31</date><risdate>2006</risdate><abstract>The present invention relates to a compound represented by formula (I), a salt thereof, an N-oxide thereof, a solvate thereof or a prodrug thereof, and medical use thereof (the symbols in the formula are as described in the specification).
The compound represented by formula (I) has chemokine receptor (especially in CCR4 and/or CCR5) antagonistic activity. Therefore it is useful for prevention and/or treatment of a chemokine receptor-mediated disease such as inflammatory and/or allergic diseases [systemic inflammatory response syndrome (SIRS), anaphylaxis, anaphylactoid reaction, allergic angiitis, transplant rejection reaction, hepatitis, nephritis, nephropathy, pancreatitis, rhinitis, arthritis, inflammatory ocular disease, inflammatory bowel disease, disease in cerebro and/or circulatory system, respiratory disease, dermatosis, autoimmune disease, and the like], infection [viral disease (human immunodeficiency virus infection, acquired immunodeficiency syndrome, SARS, etc .), and the like], and the like.</abstract><edition>7</edition><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | CHEMOKINE RECEPTOR ANTAGONIST AND MEDICAL USE THEREOF |
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