MATRIX, CELL IMPLANTATION AND METHOD FOR THEIR PRODUCTION AND USE
A porous matrix based on a biocompatible polymer or polymer mixture comprising pores of size 150 Microm or below and also pores of size 300 Microm or above, where the degree of porosity of the matrix is 93-98 %, is new. Independent claims are also included for: (1) production of a porous matrix base...
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| creator | GÖRNE, Martin KAUFMANN, Peter, Matthias |
| description | A porous matrix based on a biocompatible polymer or polymer mixture comprising pores of size 150 Microm or below and also pores of size 300 Microm or above, where the degree of porosity of the matrix is 93-98 %, is new. Independent claims are also included for: (1) production of a porous matrix based on a biodegradable polymer (mixture) by compacting a mixture of polymer particles of size 20-950 (especially 108-250) Microm and cooking salt of particle size 90-670 (especially 250-425) Microm and then dissolving out the salt; (2) production of a porous matrix based on a biocompatible polymer (mixture) by compacting a mixture of polymer particles, a pore-former and polymer solution and then dissolving out the pore-former; (3) implants comprising the matrices and cells, the cells being of >=2 types, one type being hepatocytes and another being Langerhans islets; and (4) a cell recovery process for the inoculation of implantable matrices comprising removing a piece of tissue, treating the piece with sodium chloride, potassium chloride, HEPES, calcium chloride, collagenase and trypsin inhibitor at pH 7.3-7.4, optionally freshening the tissue piece and then shaking it in a suitable medium and recovering the resulting cell suspension. |
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Independent claims are also included for: (1) production of a porous matrix based on a biodegradable polymer (mixture) by compacting a mixture of polymer particles of size 20-950 (especially 108-250) Microm and cooking salt of particle size 90-670 (especially 250-425) Microm and then dissolving out the salt; (2) production of a porous matrix based on a biocompatible polymer (mixture) by compacting a mixture of polymer particles, a pore-former and polymer solution and then dissolving out the pore-former; (3) implants comprising the matrices and cells, the cells being of >=2 types, one type being hepatocytes and another being Langerhans islets; and (4) a cell recovery process for the inoculation of implantable matrices comprising removing a piece of tissue, treating the piece with sodium chloride, potassium chloride, HEPES, calcium chloride, collagenase and trypsin inhibitor at pH 7.3-7.4, optionally freshening the tissue piece and then shaking it in a suitable medium and recovering the resulting cell suspension.</description><language>eng ; fre ; ger</language><subject>AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F,C08G ; BEER ; BIOCHEMISTRY ; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES ; CHEMISTRY ; COMPOSITIONS BASED THEREON ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR ; ENZYMOLOGY ; GENERAL PROCESSES OF COMPOUNDING ; HUMAN NECESSITIES ; HYGIENE ; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; ORGANIC MACROMOLECULAR COMPOUNDS ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPIRITS ; THEIR PREPARATION OR CHEMICAL WORKING-UP ; VINEGAR ; WINE ; WORKING-UP</subject><creationdate>2017</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20170315&DB=EPODOC&CC=EP&NR=1633807B8$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,309,781,886,25569,76552</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20170315&DB=EPODOC&CC=EP&NR=1633807B8$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>GÖRNE, Martin</creatorcontrib><creatorcontrib>KAUFMANN, Peter, Matthias</creatorcontrib><title>MATRIX, CELL IMPLANTATION AND METHOD FOR THEIR PRODUCTION AND USE</title><description>A porous matrix based on a biocompatible polymer or polymer mixture comprising pores of size 150 Microm or below and also pores of size 300 Microm or above, where the degree of porosity of the matrix is 93-98 %, is new. Independent claims are also included for: (1) production of a porous matrix based on a biodegradable polymer (mixture) by compacting a mixture of polymer particles of size 20-950 (especially 108-250) Microm and cooking salt of particle size 90-670 (especially 250-425) Microm and then dissolving out the salt; (2) production of a porous matrix based on a biocompatible polymer (mixture) by compacting a mixture of polymer particles, a pore-former and polymer solution and then dissolving out the pore-former; (3) implants comprising the matrices and cells, the cells being of >=2 types, one type being hepatocytes and another being Langerhans islets; and (4) a cell recovery process for the inoculation of implantable matrices comprising removing a piece of tissue, treating the piece with sodium chloride, potassium chloride, HEPES, calcium chloride, collagenase and trypsin inhibitor at pH 7.3-7.4, optionally freshening the tissue piece and then shaking it in a suitable medium and recovering the resulting cell suspension.</description><subject>AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F,C08G</subject><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS BASED THEREON</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>DISINFECTION, STERILISATION, OR DEODORISATION OF AIR</subject><subject>ENZYMOLOGY</subject><subject>GENERAL PROCESSES OF COMPOUNDING</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>ORGANIC MACROMOLECULAR COMPOUNDS</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPIRITS</subject><subject>THEIR PREPARATION OR CHEMICAL WORKING-UP</subject><subject>VINEGAR</subject><subject>WINE</subject><subject>WORKING-UP</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2017</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZHD0dQwJ8ozQUXB29fFR8PQN8HH0C3EM8fT3U3D0c1HwdQ3x8HdRcPMPUgjxcPUMUggI8ncJdYbLhwa78jCwpiXmFKfyQmluBgU31xBnD93Ugvz41OKCxOTUvNSSeNcAQzNjYwsDcycLYyKUAABtcipn</recordid><startdate>20170315</startdate><enddate>20170315</enddate><creator>GÖRNE, Martin</creator><creator>KAUFMANN, Peter, Matthias</creator><scope>EVB</scope></search><sort><creationdate>20170315</creationdate><title>MATRIX, CELL IMPLANTATION AND METHOD FOR THEIR PRODUCTION AND USE</title><author>GÖRNE, Martin ; 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Independent claims are also included for: (1) production of a porous matrix based on a biodegradable polymer (mixture) by compacting a mixture of polymer particles of size 20-950 (especially 108-250) Microm and cooking salt of particle size 90-670 (especially 250-425) Microm and then dissolving out the salt; (2) production of a porous matrix based on a biocompatible polymer (mixture) by compacting a mixture of polymer particles, a pore-former and polymer solution and then dissolving out the pore-former; (3) implants comprising the matrices and cells, the cells being of >=2 types, one type being hepatocytes and another being Langerhans islets; and (4) a cell recovery process for the inoculation of implantable matrices comprising removing a piece of tissue, treating the piece with sodium chloride, potassium chloride, HEPES, calcium chloride, collagenase and trypsin inhibitor at pH 7.3-7.4, optionally freshening the tissue piece and then shaking it in a suitable medium and recovering the resulting cell suspension.</abstract><oa>free_for_read</oa></addata></record> |
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| language | eng ; fre ; ger |
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| subjects | AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F,C08G BEER BIOCHEMISTRY CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES CHEMISTRY COMPOSITIONS BASED THEREON COMPOSITIONS THEREOF CULTURE MEDIA DISINFECTION, STERILISATION, OR DEODORISATION OF AIR ENZYMOLOGY GENERAL PROCESSES OF COMPOUNDING HUMAN NECESSITIES HYGIENE MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES MEDICAL OR VETERINARY SCIENCE METALLURGY METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC MACROMOLECULAR COMPOUNDS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS THEIR PREPARATION OR CHEMICAL WORKING-UP VINEGAR WINE WORKING-UP |
| title | MATRIX, CELL IMPLANTATION AND METHOD FOR THEIR PRODUCTION AND USE |
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