Correlation of the ratio of thymidine phosphorylase and dihydropyrimidine dehydrogenase mRNA expression levels in colorectal cancer with disease-free survival in 5-FU treated patients
The present invention is directed to a method for determining whether a patient suffering from cancer is susceptable to a treatment with a 5-Fluoro-Uracil analogon comprising a) determination of Thymidine Phosphorylase mRNA expression in a clinical sample, b) determination of Dihydropyrimindine Dehy...
Gespeichert in:
| Hauptverfasser: | , , , , , , |
|---|---|
| Format: | Patent |
| Sprache: | eng ; fre ; ger |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | POIGNEE, MANUELA KRAUSE, FRIEDMANN LASSMANN, SILKE WERNER, MARTIN, DR PORSTMANN, BAERBEL, DR LUTZ, VERENA WALTER, THOMAS |
| description | The present invention is directed to a method for determining whether a patient suffering from cancer is susceptable to a treatment with a 5-Fluoro-Uracil analogon comprising a) determination of Thymidine Phosphorylase mRNA expression in a clinical sample, b) determination of Dihydropyrimindine Dehydrogenase mRNA expression in said clinical sample, and c) determination of the ratio of the value obtained in step a) and the value obtained in step b). If the ratio exceeds a certain cut off, susceptability to 5-FU and/or 5-FU analoga can be expected. |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_EP1510588A1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>EP1510588A1</sourcerecordid><originalsourceid>FETCH-epo_espacenet_EP1510588A13</originalsourceid><addsrcrecordid>eNqNjkEKwjAURLtxIeod_gUKFim4FVFciYiuJSRTG4hJ-D9WezKvZ6oewMXwmeH9YcbFax2Y4VSywVNoKLUgHtzX9DdrrAfFNkgW904JSHlDxra94RB7tj_G4JNc4QfmdtyvCM_IEBm6HTo4IetJBxcYOilHWnkNpodNbS4U5MeyYYDkzp3tMpH5utyeKTFUgqGYt8EnmRajRjnB7HcnBW03p_WuRAwXSFQaHumyOVR1Na-Xy1W1-AN5Ax3ZXkY</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>Correlation of the ratio of thymidine phosphorylase and dihydropyrimidine dehydrogenase mRNA expression levels in colorectal cancer with disease-free survival in 5-FU treated patients</title><source>esp@cenet</source><creator>POIGNEE, MANUELA ; KRAUSE, FRIEDMANN ; LASSMANN, SILKE ; WERNER, MARTIN, DR ; PORSTMANN, BAERBEL, DR ; LUTZ, VERENA ; WALTER, THOMAS</creator><creatorcontrib>POIGNEE, MANUELA ; KRAUSE, FRIEDMANN ; LASSMANN, SILKE ; WERNER, MARTIN, DR ; PORSTMANN, BAERBEL, DR ; LUTZ, VERENA ; WALTER, THOMAS</creatorcontrib><description>The present invention is directed to a method for determining whether a patient suffering from cancer is susceptable to a treatment with a 5-Fluoro-Uracil analogon comprising a) determination of Thymidine Phosphorylase mRNA expression in a clinical sample, b) determination of Dihydropyrimindine Dehydrogenase mRNA expression in said clinical sample, and c) determination of the ratio of the value obtained in step a) and the value obtained in step b). If the ratio exceeds a certain cut off, susceptability to 5-FU and/or 5-FU analoga can be expected.</description><edition>7</edition><language>eng ; fre ; ger</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS OR TEST PAPERS THEREFOR ; COMPOSITIONS THEREOF ; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ; CULTURE MEDIA ; ENZYMOLOGY ; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; PROCESSES OF PREPARING SUCH COMPOSITIONS ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>2005</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20050302&DB=EPODOC&CC=EP&NR=1510588A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25563,76318</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20050302&DB=EPODOC&CC=EP&NR=1510588A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>POIGNEE, MANUELA</creatorcontrib><creatorcontrib>KRAUSE, FRIEDMANN</creatorcontrib><creatorcontrib>LASSMANN, SILKE</creatorcontrib><creatorcontrib>WERNER, MARTIN, DR</creatorcontrib><creatorcontrib>PORSTMANN, BAERBEL, DR</creatorcontrib><creatorcontrib>LUTZ, VERENA</creatorcontrib><creatorcontrib>WALTER, THOMAS</creatorcontrib><title>Correlation of the ratio of thymidine phosphorylase and dihydropyrimidine dehydrogenase mRNA expression levels in colorectal cancer with disease-free survival in 5-FU treated patients</title><description>The present invention is directed to a method for determining whether a patient suffering from cancer is susceptable to a treatment with a 5-Fluoro-Uracil analogon comprising a) determination of Thymidine Phosphorylase mRNA expression in a clinical sample, b) determination of Dihydropyrimindine Dehydrogenase mRNA expression in said clinical sample, and c) determination of the ratio of the value obtained in step a) and the value obtained in step b). If the ratio exceeds a certain cut off, susceptability to 5-FU and/or 5-FU analoga can be expected.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS OR TEST PAPERS THEREFOR</subject><subject>COMPOSITIONS THEREOF</subject><subject>CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>PROCESSES OF PREPARING SUCH COMPOSITIONS</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2005</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNjkEKwjAURLtxIeod_gUKFim4FVFciYiuJSRTG4hJ-D9WezKvZ6oewMXwmeH9YcbFax2Y4VSywVNoKLUgHtzX9DdrrAfFNkgW904JSHlDxra94RB7tj_G4JNc4QfmdtyvCM_IEBm6HTo4IetJBxcYOilHWnkNpodNbS4U5MeyYYDkzp3tMpH5utyeKTFUgqGYt8EnmRajRjnB7HcnBW03p_WuRAwXSFQaHumyOVR1Na-Xy1W1-AN5Ax3ZXkY</recordid><startdate>20050302</startdate><enddate>20050302</enddate><creator>POIGNEE, MANUELA</creator><creator>KRAUSE, FRIEDMANN</creator><creator>LASSMANN, SILKE</creator><creator>WERNER, MARTIN, DR</creator><creator>PORSTMANN, BAERBEL, DR</creator><creator>LUTZ, VERENA</creator><creator>WALTER, THOMAS</creator><scope>EVB</scope></search><sort><creationdate>20050302</creationdate><title>Correlation of the ratio of thymidine phosphorylase and dihydropyrimidine dehydrogenase mRNA expression levels in colorectal cancer with disease-free survival in 5-FU treated patients</title><author>POIGNEE, MANUELA ; KRAUSE, FRIEDMANN ; LASSMANN, SILKE ; WERNER, MARTIN, DR ; PORSTMANN, BAERBEL, DR ; LUTZ, VERENA ; WALTER, THOMAS</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_EP1510588A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre ; ger</language><creationdate>2005</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS OR TEST PAPERS THEREFOR</topic><topic>COMPOSITIONS THEREOF</topic><topic>CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>PROCESSES OF PREPARING SUCH COMPOSITIONS</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPIRITS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>POIGNEE, MANUELA</creatorcontrib><creatorcontrib>KRAUSE, FRIEDMANN</creatorcontrib><creatorcontrib>LASSMANN, SILKE</creatorcontrib><creatorcontrib>WERNER, MARTIN, DR</creatorcontrib><creatorcontrib>PORSTMANN, BAERBEL, DR</creatorcontrib><creatorcontrib>LUTZ, VERENA</creatorcontrib><creatorcontrib>WALTER, THOMAS</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>POIGNEE, MANUELA</au><au>KRAUSE, FRIEDMANN</au><au>LASSMANN, SILKE</au><au>WERNER, MARTIN, DR</au><au>PORSTMANN, BAERBEL, DR</au><au>LUTZ, VERENA</au><au>WALTER, THOMAS</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Correlation of the ratio of thymidine phosphorylase and dihydropyrimidine dehydrogenase mRNA expression levels in colorectal cancer with disease-free survival in 5-FU treated patients</title><date>2005-03-02</date><risdate>2005</risdate><abstract>The present invention is directed to a method for determining whether a patient suffering from cancer is susceptable to a treatment with a 5-Fluoro-Uracil analogon comprising a) determination of Thymidine Phosphorylase mRNA expression in a clinical sample, b) determination of Dihydropyrimindine Dehydrogenase mRNA expression in said clinical sample, and c) determination of the ratio of the value obtained in step a) and the value obtained in step b). If the ratio exceeds a certain cut off, susceptability to 5-FU and/or 5-FU analoga can be expected.</abstract><edition>7</edition><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | eng ; fre ; ger |
| recordid | cdi_epo_espacenet_EP1510588A1 |
| source | esp@cenet |
| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA ENZYMOLOGY MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROCESSES OF PREPARING SUCH COMPOSITIONS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE |
| title | Correlation of the ratio of thymidine phosphorylase and dihydropyrimidine dehydrogenase mRNA expression levels in colorectal cancer with disease-free survival in 5-FU treated patients |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-11T20%3A35%3A51IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=POIGNEE,%20MANUELA&rft.date=2005-03-02&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3EEP1510588A1%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |