DEVICE FOR PRESENTING POLYPEPTIDES, ABLE TO BE USED AS A CHIP FOR MINIATURISED DETECTION OF MOLECULES

The invention concerns a device for presentation of peptides or of proteins, which can be used as a "polypeptide chip" for the miniaturised detection of molecules structurally or functionally complementary to the said polypeptides. This device consists of a flat support onto which the polypeptides are covalently bonded, this bonding between the polypeptides and the support resulting from the formation of a semicarbazone bond. The semicarbazone bond results in particular from the reaction between polypeptides bearing an aldehyde or ketone function and a support functionalised with semicarbazide groups. The invention also concerns the process for preparation of the supports and for attaching polypeptides onto these supports and also the use of the devices thus obtained as polypeptide chips.