FRAGMENTS OF THE RETINOIC ACID-RELATED ORPHAN RECEPTOR (ROR) COMPRISING THE LIGAND BINDING DOMAIN (LBD), CRYSTAL STRUCTURE OF THE LBD OF ROR-BETA AND THEIR APPLICATIONS
The invention relates to polypeptides derived from the retinoic acid-related orphan receptor (ROR) in mammals, characterized in that they are delimited in their N-terminal extremity by an amino-acid located between positions 1 to 209, and in their C-terminal extremity by an amino-acid located betwee...
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| creator | RENAUD, JEAN-PAUL WURTZ, JEAN-MARIE SCHUELE, ROLAND GREINER, ERICH, FRIEDRICH MORAS, DINO STEHLIN, CATHERINE |
| description | The invention relates to polypeptides derived from the retinoic acid-related orphan receptor (ROR) in mammals, characterized in that they are delimited in their N-terminal extremity by an amino-acid located between positions 1 to 209, and in their C-terminal extremity by an amino-acid located between positions 450 to 452 of the rat RORbeta, alpha, or gamma, or by an amino-acid located at corresponding positions in nuclear receptor ROR of other subtypes than alpha, beta and gamma, and/or of the other mammals. The invention also relates to the use of these polypeptides, or of the molecular complexes or the crystals containing them, for carrying out:-a process for the screening of a ROR-LBD ligand which is an agonist, or an antagonist of said receptor,-or a process for the analysis of the tridimensional structure of the complexes formed with said polypeptides, molecular complexes or crystals and a particular compound. |
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The invention also relates to the use of these polypeptides, or of the molecular complexes or the crystals containing them, for carrying out:-a process for the screening of a ROR-LBD ligand which is an agonist, or an antagonist of said receptor,-or a process for the analysis of the tridimensional structure of the complexes formed with said polypeptides, molecular complexes or crystals and a particular compound.</description><language>eng ; fre ; ger</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE ; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES ; MEASURING ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; ORGANIC CHEMISTRY ; PEPTIDES ; PHYSICS ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPIRITS ; TESTING ; VINEGAR ; WINE</subject><creationdate>2008</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20080416&DB=EPODOC&CC=EP&NR=1385885B1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,777,882,25545,76296</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20080416&DB=EPODOC&CC=EP&NR=1385885B1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>RENAUD, JEAN-PAUL</creatorcontrib><creatorcontrib>WURTZ, JEAN-MARIE</creatorcontrib><creatorcontrib>SCHUELE, ROLAND</creatorcontrib><creatorcontrib>GREINER, ERICH, FRIEDRICH</creatorcontrib><creatorcontrib>MORAS, DINO</creatorcontrib><creatorcontrib>STEHLIN, CATHERINE</creatorcontrib><title>FRAGMENTS OF THE RETINOIC ACID-RELATED ORPHAN RECEPTOR (ROR) COMPRISING THE LIGAND BINDING DOMAIN (LBD), CRYSTAL STRUCTURE OF THE LBD OF ROR-BETA AND THEIR APPLICATIONS</title><description>The invention relates to polypeptides derived from the retinoic acid-related orphan receptor (ROR) in mammals, characterized in that they are delimited in their N-terminal extremity by an amino-acid located between positions 1 to 209, and in their C-terminal extremity by an amino-acid located between positions 450 to 452 of the rat RORbeta, alpha, or gamma, or by an amino-acid located at corresponding positions in nuclear receptor ROR of other subtypes than alpha, beta and gamma, and/or of the other mammals. The invention also relates to the use of these polypeptides, or of the molecular complexes or the crystals containing them, for carrying out:-a process for the screening of a ROR-LBD ligand which is an agonist, or an antagonist of said receptor,-or a process for the analysis of the tridimensional structure of the complexes formed with said polypeptides, molecular complexes or crystals and a particular compound.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE</subject><subject>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</subject><subject>MEASURING</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PHYSICS</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPIRITS</subject><subject>TESTING</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2008</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNTT2LwkAQTWNx6P2HKRUuRQhC2snuJBnY7C6zk8JKRNZKVPB-1P3MS46zt3qP9_lR_HSC_UheE4QOdCAQUvaBDaBhWwo5VLIQJA7oZ9NQ1CCwlSA7MGGMwol9_1d13KO30LK3i2TDiOxh61q7-wIjh6ToIKlMRieh1-FsL3QeLFtShGVi1lkAY3RsUDn4tClWl9P1mT__cV1AR2qGMj_ux_x8nM75lr-PFKu62TfNvq3qNyK_b-5FvQ</recordid><startdate>20080416</startdate><enddate>20080416</enddate><creator>RENAUD, JEAN-PAUL</creator><creator>WURTZ, JEAN-MARIE</creator><creator>SCHUELE, ROLAND</creator><creator>GREINER, ERICH, FRIEDRICH</creator><creator>MORAS, DINO</creator><creator>STEHLIN, CATHERINE</creator><scope>EVB</scope></search><sort><creationdate>20080416</creationdate><title>FRAGMENTS OF THE RETINOIC ACID-RELATED ORPHAN RECEPTOR (ROR) COMPRISING THE LIGAND BINDING DOMAIN (LBD), CRYSTAL STRUCTURE OF THE LBD OF ROR-BETA AND THEIR APPLICATIONS</title><author>RENAUD, JEAN-PAUL ; WURTZ, JEAN-MARIE ; SCHUELE, ROLAND ; GREINER, ERICH, FRIEDRICH ; MORAS, DINO ; STEHLIN, CATHERINE</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_EP1385885B13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre ; ger</language><creationdate>2008</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE</topic><topic>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</topic><topic>MEASURING</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PHYSICS</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPIRITS</topic><topic>TESTING</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>RENAUD, JEAN-PAUL</creatorcontrib><creatorcontrib>WURTZ, JEAN-MARIE</creatorcontrib><creatorcontrib>SCHUELE, ROLAND</creatorcontrib><creatorcontrib>GREINER, ERICH, FRIEDRICH</creatorcontrib><creatorcontrib>MORAS, DINO</creatorcontrib><creatorcontrib>STEHLIN, CATHERINE</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>RENAUD, JEAN-PAUL</au><au>WURTZ, JEAN-MARIE</au><au>SCHUELE, ROLAND</au><au>GREINER, ERICH, FRIEDRICH</au><au>MORAS, DINO</au><au>STEHLIN, CATHERINE</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>FRAGMENTS OF THE RETINOIC ACID-RELATED ORPHAN RECEPTOR (ROR) COMPRISING THE LIGAND BINDING DOMAIN (LBD), CRYSTAL STRUCTURE OF THE LBD OF ROR-BETA AND THEIR APPLICATIONS</title><date>2008-04-16</date><risdate>2008</risdate><abstract>The invention relates to polypeptides derived from the retinoic acid-related orphan receptor (ROR) in mammals, characterized in that they are delimited in their N-terminal extremity by an amino-acid located between positions 1 to 209, and in their C-terminal extremity by an amino-acid located between positions 450 to 452 of the rat RORbeta, alpha, or gamma, or by an amino-acid located at corresponding positions in nuclear receptor ROR of other subtypes than alpha, beta and gamma, and/or of the other mammals. The invention also relates to the use of these polypeptides, or of the molecular complexes or the crystals containing them, for carrying out:-a process for the screening of a ROR-LBD ligand which is an agonist, or an antagonist of said receptor,-or a process for the analysis of the tridimensional structure of the complexes formed with said polypeptides, molecular complexes or crystals and a particular compound.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS TESTING VINEGAR WINE |
| title | FRAGMENTS OF THE RETINOIC ACID-RELATED ORPHAN RECEPTOR (ROR) COMPRISING THE LIGAND BINDING DOMAIN (LBD), CRYSTAL STRUCTURE OF THE LBD OF ROR-BETA AND THEIR APPLICATIONS |
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