Production method for biarylalanine

There is provided a method for producing a biarylalanine compound of formula (4): wherein R 1 represents an amino protective group, and R 2 represents an amino protective group or a hydrogen atom, R 3 is a carboxy protective group, or said amino protective and carboxy protective groups together form...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: UEDA, HIROSHI, KURIMOTO, ISAO
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page
container_issue
container_start_page
container_title
container_volume
creator UEDA, HIROSHI
KURIMOTO, ISAO
description There is provided a method for producing a biarylalanine compound of formula (4): wherein R 1 represents an amino protective group, and R 2 represents an amino protective group or a hydrogen atom, R 3 is a carboxy protective group, or said amino protective and carboxy protective groups together form an amino acid protective group, and R 4 is a substituted or unsubstituted aryl or heteroaryl group, which comprises reacting an aromatic amino acid of formula (1): wherein X is a halogen atom or a trifluoromethanesulfonyloxy group, and R 1 , R 2 and R 3 are the same as defined above, with an organic boron compound of formula (2): wherein R 4 has the same meaning as defined above, and Q 1 and Q 2 are the same or different and independently represent a hydroxy group or an alkoxy group having 1 to 4 carbon atoms, or Q 1 and Q 2 together form an alkylenedioxy or 1,2-phenylenedioxy group optionally substituted by an alkyl group having 1 to 4 carbon atoms, or a boroxine ring compound of formula (3): wherein R 4 has the same meaning as defined above, or a mixture thereof, in the presence of a nickel catalyst and a base.
format Patent
fullrecord <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_EP1346971B1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>EP1346971B1</sourcerecordid><originalsourceid>FETCH-epo_espacenet_EP1346971B13</originalsourceid><addsrcrecordid>eNrjZFAOKMpPKU0uyczPU8hNLcnIT1FIyy9SSMpMLKrMScxJzMvMS-VhYE1LzClO5YXS3AwKbq4hzh66qQX58anFBYnJqXmpJfGuAYbGJmaW5oZOhsZEKAEAuDcmXA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>Production method for biarylalanine</title><source>esp@cenet</source><creator>UEDA, HIROSHI ; KURIMOTO, ISAO</creator><creatorcontrib>UEDA, HIROSHI ; KURIMOTO, ISAO</creatorcontrib><description>There is provided a method for producing a biarylalanine compound of formula (4): wherein R 1 represents an amino protective group, and R 2 represents an amino protective group or a hydrogen atom, R 3 is a carboxy protective group, or said amino protective and carboxy protective groups together form an amino acid protective group, and R 4 is a substituted or unsubstituted aryl or heteroaryl group, which comprises reacting an aromatic amino acid of formula (1): wherein X is a halogen atom or a trifluoromethanesulfonyloxy group, and R 1 , R 2 and R 3 are the same as defined above, with an organic boron compound of formula (2): wherein R 4 has the same meaning as defined above, and Q 1 and Q 2 are the same or different and independently represent a hydroxy group or an alkoxy group having 1 to 4 carbon atoms, or Q 1 and Q 2 together form an alkylenedioxy or 1,2-phenylenedioxy group optionally substituted by an alkyl group having 1 to 4 carbon atoms, or a boroxine ring compound of formula (3): wherein R 4 has the same meaning as defined above, or a mixture thereof, in the presence of a nickel catalyst and a base.</description><language>eng ; fre ; ger</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; APPARATUS THEREFOR ; BLASTING ; CHEMISTRY ; DISPOSAL OF SOLID WASTE ; DRYING ; DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM ; GENERAL METHODS OF ORGANIC CHEMISTRY ; HEATING ; HETEROCYCLIC COMPOUNDS ; LIGHTING ; MECHANICAL ENGINEERING ; METALLURGY ; ORGANIC CHEMISTRY ; PERFORMING OPERATIONS ; RECLAMATION OF CONTAMINED SOIL SOIL ; TRANSPORTING ; TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE ; WEAPONS</subject><creationdate>2010</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&amp;date=20100120&amp;DB=EPODOC&amp;CC=EP&amp;NR=1346971B1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,777,882,25545,76296</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&amp;date=20100120&amp;DB=EPODOC&amp;CC=EP&amp;NR=1346971B1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>UEDA, HIROSHI</creatorcontrib><creatorcontrib>KURIMOTO, ISAO</creatorcontrib><title>Production method for biarylalanine</title><description>There is provided a method for producing a biarylalanine compound of formula (4): wherein R 1 represents an amino protective group, and R 2 represents an amino protective group or a hydrogen atom, R 3 is a carboxy protective group, or said amino protective and carboxy protective groups together form an amino acid protective group, and R 4 is a substituted or unsubstituted aryl or heteroaryl group, which comprises reacting an aromatic amino acid of formula (1): wherein X is a halogen atom or a trifluoromethanesulfonyloxy group, and R 1 , R 2 and R 3 are the same as defined above, with an organic boron compound of formula (2): wherein R 4 has the same meaning as defined above, and Q 1 and Q 2 are the same or different and independently represent a hydroxy group or an alkoxy group having 1 to 4 carbon atoms, or Q 1 and Q 2 together form an alkylenedioxy or 1,2-phenylenedioxy group optionally substituted by an alkyl group having 1 to 4 carbon atoms, or a boroxine ring compound of formula (3): wherein R 4 has the same meaning as defined above, or a mixture thereof, in the presence of a nickel catalyst and a base.</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>APPARATUS THEREFOR</subject><subject>BLASTING</subject><subject>CHEMISTRY</subject><subject>DISPOSAL OF SOLID WASTE</subject><subject>DRYING</subject><subject>DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM</subject><subject>GENERAL METHODS OF ORGANIC CHEMISTRY</subject><subject>HEATING</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>LIGHTING</subject><subject>MECHANICAL ENGINEERING</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PERFORMING OPERATIONS</subject><subject>RECLAMATION OF CONTAMINED SOIL SOIL</subject><subject>TRANSPORTING</subject><subject>TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE</subject><subject>WEAPONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2010</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZFAOKMpPKU0uyczPU8hNLcnIT1FIyy9SSMpMLKrMScxJzMvMS-VhYE1LzClO5YXS3AwKbq4hzh66qQX58anFBYnJqXmpJfGuAYbGJmaW5oZOhsZEKAEAuDcmXA</recordid><startdate>20100120</startdate><enddate>20100120</enddate><creator>UEDA, HIROSHI</creator><creator>KURIMOTO, ISAO</creator><scope>EVB</scope></search><sort><creationdate>20100120</creationdate><title>Production method for biarylalanine</title><author>UEDA, HIROSHI ; KURIMOTO, ISAO</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_EP1346971B13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre ; ger</language><creationdate>2010</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>APPARATUS THEREFOR</topic><topic>BLASTING</topic><topic>CHEMISTRY</topic><topic>DISPOSAL OF SOLID WASTE</topic><topic>DRYING</topic><topic>DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM</topic><topic>GENERAL METHODS OF ORGANIC CHEMISTRY</topic><topic>HEATING</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>LIGHTING</topic><topic>MECHANICAL ENGINEERING</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PERFORMING OPERATIONS</topic><topic>RECLAMATION OF CONTAMINED SOIL SOIL</topic><topic>TRANSPORTING</topic><topic>TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE</topic><topic>WEAPONS</topic><toplevel>online_resources</toplevel><creatorcontrib>UEDA, HIROSHI</creatorcontrib><creatorcontrib>KURIMOTO, ISAO</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>UEDA, HIROSHI</au><au>KURIMOTO, ISAO</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Production method for biarylalanine</title><date>2010-01-20</date><risdate>2010</risdate><abstract>There is provided a method for producing a biarylalanine compound of formula (4): wherein R 1 represents an amino protective group, and R 2 represents an amino protective group or a hydrogen atom, R 3 is a carboxy protective group, or said amino protective and carboxy protective groups together form an amino acid protective group, and R 4 is a substituted or unsubstituted aryl or heteroaryl group, which comprises reacting an aromatic amino acid of formula (1): wherein X is a halogen atom or a trifluoromethanesulfonyloxy group, and R 1 , R 2 and R 3 are the same as defined above, with an organic boron compound of formula (2): wherein R 4 has the same meaning as defined above, and Q 1 and Q 2 are the same or different and independently represent a hydroxy group or an alkoxy group having 1 to 4 carbon atoms, or Q 1 and Q 2 together form an alkylenedioxy or 1,2-phenylenedioxy group optionally substituted by an alkyl group having 1 to 4 carbon atoms, or a boroxine ring compound of formula (3): wherein R 4 has the same meaning as defined above, or a mixture thereof, in the presence of a nickel catalyst and a base.</abstract><oa>free_for_read</oa></addata></record>
fulltext fulltext_linktorsrc
identifier
ispartof
issn
language eng ; fre ; ger
recordid cdi_epo_espacenet_EP1346971B1
source esp@cenet
subjects ACYCLIC OR CARBOCYCLIC COMPOUNDS
APPARATUS THEREFOR
BLASTING
CHEMISTRY
DISPOSAL OF SOLID WASTE
DRYING
DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
GENERAL METHODS OF ORGANIC CHEMISTRY
HEATING
HETEROCYCLIC COMPOUNDS
LIGHTING
MECHANICAL ENGINEERING
METALLURGY
ORGANIC CHEMISTRY
PERFORMING OPERATIONS
RECLAMATION OF CONTAMINED SOIL SOIL
TRANSPORTING
TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
WEAPONS
title Production method for biarylalanine
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-17T14%3A33%3A24IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=UEDA,%20HIROSHI&rft.date=2010-01-20&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3EEP1346971B1%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true