Production method for biarylalanine
There is provided a method for producing a biarylalanine compound of formula (4): wherein R 1 represents an amino protective group, and R 2 represents an amino protective group or a hydrogen atom, R 3 is a carboxy protective group, or said amino protective and carboxy protective groups together form...
Gespeichert in:
Hauptverfasser: | , |
---|---|
Format: | Patent |
Sprache: | eng ; fre ; ger |
Schlagworte: | |
Online-Zugang: | Volltext bestellen |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | |
---|---|
container_issue | |
container_start_page | |
container_title | |
container_volume | |
creator | UEDA, HIROSHI KURIMOTO, ISAO |
description | There is provided a method for producing a biarylalanine compound of formula (4):
wherein
R 1 represents an amino protective group, and R 2 represents an amino protective group or a hydrogen atom,
R 3 is a carboxy protective group, or
said amino protective and carboxy protective groups together form an amino acid protective group, and
R 4 is a substituted or unsubstituted aryl or heteroaryl group, which comprises reacting an aromatic amino acid of formula (1): wherein
X is a halogen atom or a trifluoromethanesulfonyloxy group, and
R 1 , R 2 and R 3 are the same as defined above, with an organic boron compound of formula (2): wherein R 4 has the same meaning as defined above, and
Q 1 and Q 2 are the same or different and independently represent a hydroxy group or an alkoxy group having 1 to 4 carbon atoms, or
Q 1 and Q 2 together form an alkylenedioxy or 1,2-phenylenedioxy group optionally substituted by an alkyl group having 1 to 4 carbon atoms,
or
a boroxine ring compound of formula (3):
wherein R 4 has the same meaning as defined above, or a mixture thereof, in the presence of a nickel catalyst and a base. |
format | Patent |
fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_EP1346971B1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>EP1346971B1</sourcerecordid><originalsourceid>FETCH-epo_espacenet_EP1346971B13</originalsourceid><addsrcrecordid>eNrjZFAOKMpPKU0uyczPU8hNLcnIT1FIyy9SSMpMLKrMScxJzMvMS-VhYE1LzClO5YXS3AwKbq4hzh66qQX58anFBYnJqXmpJfGuAYbGJmaW5oZOhsZEKAEAuDcmXA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>Production method for biarylalanine</title><source>esp@cenet</source><creator>UEDA, HIROSHI ; KURIMOTO, ISAO</creator><creatorcontrib>UEDA, HIROSHI ; KURIMOTO, ISAO</creatorcontrib><description>There is provided a method for producing a biarylalanine compound of formula (4):
wherein
R 1 represents an amino protective group, and R 2 represents an amino protective group or a hydrogen atom,
R 3 is a carboxy protective group, or
said amino protective and carboxy protective groups together form an amino acid protective group, and
R 4 is a substituted or unsubstituted aryl or heteroaryl group, which comprises reacting an aromatic amino acid of formula (1): wherein
X is a halogen atom or a trifluoromethanesulfonyloxy group, and
R 1 , R 2 and R 3 are the same as defined above, with an organic boron compound of formula (2): wherein R 4 has the same meaning as defined above, and
Q 1 and Q 2 are the same or different and independently represent a hydroxy group or an alkoxy group having 1 to 4 carbon atoms, or
Q 1 and Q 2 together form an alkylenedioxy or 1,2-phenylenedioxy group optionally substituted by an alkyl group having 1 to 4 carbon atoms,
or
a boroxine ring compound of formula (3):
wherein R 4 has the same meaning as defined above, or a mixture thereof, in the presence of a nickel catalyst and a base.</description><language>eng ; fre ; ger</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; APPARATUS THEREFOR ; BLASTING ; CHEMISTRY ; DISPOSAL OF SOLID WASTE ; DRYING ; DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM ; GENERAL METHODS OF ORGANIC CHEMISTRY ; HEATING ; HETEROCYCLIC COMPOUNDS ; LIGHTING ; MECHANICAL ENGINEERING ; METALLURGY ; ORGANIC CHEMISTRY ; PERFORMING OPERATIONS ; RECLAMATION OF CONTAMINED SOIL SOIL ; TRANSPORTING ; TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE ; WEAPONS</subject><creationdate>2010</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20100120&DB=EPODOC&CC=EP&NR=1346971B1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,777,882,25545,76296</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20100120&DB=EPODOC&CC=EP&NR=1346971B1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>UEDA, HIROSHI</creatorcontrib><creatorcontrib>KURIMOTO, ISAO</creatorcontrib><title>Production method for biarylalanine</title><description>There is provided a method for producing a biarylalanine compound of formula (4):
wherein
R 1 represents an amino protective group, and R 2 represents an amino protective group or a hydrogen atom,
R 3 is a carboxy protective group, or
said amino protective and carboxy protective groups together form an amino acid protective group, and
R 4 is a substituted or unsubstituted aryl or heteroaryl group, which comprises reacting an aromatic amino acid of formula (1): wherein
X is a halogen atom or a trifluoromethanesulfonyloxy group, and
R 1 , R 2 and R 3 are the same as defined above, with an organic boron compound of formula (2): wherein R 4 has the same meaning as defined above, and
Q 1 and Q 2 are the same or different and independently represent a hydroxy group or an alkoxy group having 1 to 4 carbon atoms, or
Q 1 and Q 2 together form an alkylenedioxy or 1,2-phenylenedioxy group optionally substituted by an alkyl group having 1 to 4 carbon atoms,
or
a boroxine ring compound of formula (3):
wherein R 4 has the same meaning as defined above, or a mixture thereof, in the presence of a nickel catalyst and a base.</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>APPARATUS THEREFOR</subject><subject>BLASTING</subject><subject>CHEMISTRY</subject><subject>DISPOSAL OF SOLID WASTE</subject><subject>DRYING</subject><subject>DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM</subject><subject>GENERAL METHODS OF ORGANIC CHEMISTRY</subject><subject>HEATING</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>LIGHTING</subject><subject>MECHANICAL ENGINEERING</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PERFORMING OPERATIONS</subject><subject>RECLAMATION OF CONTAMINED SOIL SOIL</subject><subject>TRANSPORTING</subject><subject>TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE</subject><subject>WEAPONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2010</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZFAOKMpPKU0uyczPU8hNLcnIT1FIyy9SSMpMLKrMScxJzMvMS-VhYE1LzClO5YXS3AwKbq4hzh66qQX58anFBYnJqXmpJfGuAYbGJmaW5oZOhsZEKAEAuDcmXA</recordid><startdate>20100120</startdate><enddate>20100120</enddate><creator>UEDA, HIROSHI</creator><creator>KURIMOTO, ISAO</creator><scope>EVB</scope></search><sort><creationdate>20100120</creationdate><title>Production method for biarylalanine</title><author>UEDA, HIROSHI ; KURIMOTO, ISAO</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_EP1346971B13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre ; ger</language><creationdate>2010</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>APPARATUS THEREFOR</topic><topic>BLASTING</topic><topic>CHEMISTRY</topic><topic>DISPOSAL OF SOLID WASTE</topic><topic>DRYING</topic><topic>DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM</topic><topic>GENERAL METHODS OF ORGANIC CHEMISTRY</topic><topic>HEATING</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>LIGHTING</topic><topic>MECHANICAL ENGINEERING</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PERFORMING OPERATIONS</topic><topic>RECLAMATION OF CONTAMINED SOIL SOIL</topic><topic>TRANSPORTING</topic><topic>TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE</topic><topic>WEAPONS</topic><toplevel>online_resources</toplevel><creatorcontrib>UEDA, HIROSHI</creatorcontrib><creatorcontrib>KURIMOTO, ISAO</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>UEDA, HIROSHI</au><au>KURIMOTO, ISAO</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Production method for biarylalanine</title><date>2010-01-20</date><risdate>2010</risdate><abstract>There is provided a method for producing a biarylalanine compound of formula (4):
wherein
R 1 represents an amino protective group, and R 2 represents an amino protective group or a hydrogen atom,
R 3 is a carboxy protective group, or
said amino protective and carboxy protective groups together form an amino acid protective group, and
R 4 is a substituted or unsubstituted aryl or heteroaryl group, which comprises reacting an aromatic amino acid of formula (1): wherein
X is a halogen atom or a trifluoromethanesulfonyloxy group, and
R 1 , R 2 and R 3 are the same as defined above, with an organic boron compound of formula (2): wherein R 4 has the same meaning as defined above, and
Q 1 and Q 2 are the same or different and independently represent a hydroxy group or an alkoxy group having 1 to 4 carbon atoms, or
Q 1 and Q 2 together form an alkylenedioxy or 1,2-phenylenedioxy group optionally substituted by an alkyl group having 1 to 4 carbon atoms,
or
a boroxine ring compound of formula (3):
wherein R 4 has the same meaning as defined above, or a mixture thereof, in the presence of a nickel catalyst and a base.</abstract><oa>free_for_read</oa></addata></record> |
fulltext | fulltext_linktorsrc |
identifier | |
ispartof | |
issn | |
language | eng ; fre ; ger |
recordid | cdi_epo_espacenet_EP1346971B1 |
source | esp@cenet |
subjects | ACYCLIC OR CARBOCYCLIC COMPOUNDS APPARATUS THEREFOR BLASTING CHEMISTRY DISPOSAL OF SOLID WASTE DRYING DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM GENERAL METHODS OF ORGANIC CHEMISTRY HEATING HETEROCYCLIC COMPOUNDS LIGHTING MECHANICAL ENGINEERING METALLURGY ORGANIC CHEMISTRY PERFORMING OPERATIONS RECLAMATION OF CONTAMINED SOIL SOIL TRANSPORTING TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE WEAPONS |
title | Production method for biarylalanine |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-17T14%3A33%3A24IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=UEDA,%20HIROSHI&rft.date=2010-01-20&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3EEP1346971B1%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |