CRYSTAL STRUCTURE OF BACE AND USES THEREOF
This invention is directed to the three dimensional crystal structure of Beta-site APP Cleaving Enzyme (BACE), and to the use of this structure in rational drug design methods to identify agents that may interact with active sites of BACE. Such agents may represent new therapeutics in the treatment...
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| creator | CHOPPA, RAJIV STAHL, MARK, LLOYD AKOPIAN, TATOS, N BARD, JONATHAN SVENSON, KRISTINE ANNIS, BETHANY SOMERS, WILLIAM, S |
| description | This invention is directed to the three dimensional crystal structure of Beta-site APP Cleaving Enzyme (BACE), and to the use of this structure in rational drug design methods to identify agents that may interact with active sites of BACE. Such agents may represent new therapeutics in the treatment and/or prevention of Alzheimer's Disease. |
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Such agents may represent new therapeutics in the treatment and/or prevention of Alzheimer's Disease.</description><edition>7</edition><language>eng ; fre ; ger</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; ORGANIC CHEMISTRY ; PEPTIDES ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>2005</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20050209&DB=EPODOC&CC=EP&NR=1327143A4$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20050209&DB=EPODOC&CC=EP&NR=1327143A4$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>CHOPPA, RAJIV</creatorcontrib><creatorcontrib>STAHL, MARK, LLOYD</creatorcontrib><creatorcontrib>AKOPIAN, TATOS, N</creatorcontrib><creatorcontrib>BARD, JONATHAN</creatorcontrib><creatorcontrib>SVENSON, KRISTINE</creatorcontrib><creatorcontrib>ANNIS, BETHANY</creatorcontrib><creatorcontrib>SOMERS, WILLIAM, S</creatorcontrib><title>CRYSTAL STRUCTURE OF BACE AND USES THEREOF</title><description>This invention is directed to the three dimensional crystal structure of Beta-site APP Cleaving Enzyme (BACE), and to the use of this structure in rational drug design methods to identify agents that may interact with active sites of BACE. 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Such agents may represent new therapeutics in the treatment and/or prevention of Alzheimer's Disease.</abstract><edition>7</edition><oa>free_for_read</oa></addata></record> |
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| language | eng ; fre ; ger |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE |
| title | CRYSTAL STRUCTURE OF BACE AND USES THEREOF |
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