GENE CONSTRUCT FOR PRODRUG ACTIVATION ENCODING A HETEROLOGOUS, GLYCOSYLPHOPHATIDYLINOSITOL-MODIFIED CARBOXYPEPTIDASE G2 AND A CELL SURFACE TARGETING SIGNAL PEPTIDE

This invention relates particularly to gene directed enzyme prodrug therapy (GDEPT) using post translational glycosylphosphatidylinositol (GPI addition to a prodrug activating enzyme to enable anchorage of the enzyme at the cell surface, particularly for use in cancer therapy. A preferred prodrug ac...

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Hauptverfasser: LOWENSTEIN, PEDRO, RICARDO, CASTRO, MARIA, GRACIELA, EMERY, STEPHEN, CHARLES
Format: Patent
Sprache:eng ; fre ; ger
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Zusammenfassung:This invention relates particularly to gene directed enzyme prodrug therapy (GDEPT) using post translational glycosylphosphatidylinositol (GPI addition to a prodrug activating enzyme to enable anchorage of the enzyme at the cell surface, particularly for use in cancer therapy. A preferred prodrug activating enzyme is carboxypeptidase G2.