Dimethyl-(3-aryl-but-3-enyl) amine derivatives with analgesic activity
Es werden Dimethyl-(3-aryl-but-3-enyl)-aminverbindungen der allgemeinen Formel 1, Verfahren zu deren Herstellung sowie die Verwendung dieser Verbindungen als pharmazeutische Wirkstoffe beschrieben. in der R C1-5-Alkyl ist und R H oder C-1-5-Alkyl bedeutet oder R und R zusammen -(CH2)2-4-, -(CH2)2-CH...
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| creator | BUSCHMANN, HELMUT HEINRICH FRIDERICHS, ELMAR JOSEF KOEGEL, BABETTE-YVONNE STRASSBURGER, WOLFGANG WERNER ALFRED, -DR |
| description | Es werden Dimethyl-(3-aryl-but-3-enyl)-aminverbindungen der allgemeinen Formel 1, Verfahren zu deren Herstellung sowie die Verwendung dieser Verbindungen als pharmazeutische Wirkstoffe beschrieben. in der R C1-5-Alkyl ist und R H oder C-1-5-Alkyl bedeutet oder R und R zusammen -(CH2)2-4-, -(CH2)2-CHR oder -CH2-CHR -CH2- darstellen, R H oder C1-5-Alkyl bedeutet, R H, OH, C1-4-Alkyl, O-C1-4-Alkyl, O-Benzyl, CF3, O-CF3, Cl, F oder OR bedeutet, R H, OH, C1-4-Alkyl, O-C1-4-Alkyl, O-Benzyl, CHF2, CF3, O-CF3, Cl, F oder OR darstellt und R H, OH, C1-4-Alkyl, O-C1-4-Alkyl, O-Benzyl, CF3, O-CF3, Cl, F oder OR bedeutet, mit der Maßgabe, daß zwei der Reste R , R oder R H sind, oder R und R zusammen -CH=C(R )-O- oder -CH=C(R )-S- bedeuten, mit der Maßgabe, daß R H ist, oder R und R zusammen -CH=CH-C(OR )=CH- bedeuten, mit der Maßgabe, daß R H ist.
Dimethyl-(3-aryl-but-3-enyl)amine compounds of formula (I) and their salts, as enantiomers or racemates, are new. R1 = 1-5C alkyl; R2, R3 = H or 1-5C alkyl; or R1+R2 = (CH2)2, (CH2)3, (CH2)4, (CH2)2CHR7 or CH2-CHR7-CH2; R4, R6 = H, OH, 1-4C alkyl, 1-4C alkoxy, benzyloxy, CF3, OCF3, Cl, F or OR8; R5 = CHF2 or as for R4; provided that two of R4-R6 = H; or R4 = H and R5+R6 = CH=CH-C(OR10)=CH; or R4+R5 = CH=C(R9)-O and R6 = H; R7 = 1-8C alkyl, 3-8C cycloalkyl, 1-4C alkoxy, benzyloxy, CF3, Cl or F; R8 = phenyl, pyridyl, thienyl, thiazolyl (all optionally substituted), CO-T or PO(OR)2; T = 1-5C alkyl, 1-5C alkoxy, C6H4-R11, CHR12-NHR13 or NH-C6H3(R14)2; R = 1-4C alkyl; R9 = H or 1-4C alkyl; R10 = H or 1-3C alkyl; R11 = (1-3C alkyl)carbonyloxy in the o-position, or CH2N(R15)2 in the m- or p- position; R12, R13 = H, 1-6C alkyl or 3-8C cycloalkyl; or R12+R13 = (CH2)n; n = 3-8; R14 = independently H, OH, 1-7C alkyl , 1-7C alkoxy, phenyl, aryloxy, CF3, Cl or F; R15 = R; or N(R15)2 = morpholino; provided that the racemate (I; R1+R2 = (CH2)3; R3, R4, R6 = H; R5 = OMe) is excluded. |
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| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_EP1069106A2</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>EP1069106A2</sourcerecordid><originalsourceid>FETCH-epo_espacenet_EP1069106A23</originalsourceid><addsrcrecordid>eNrjZHBzycxNLcmozNHVMNZNLALSSaUlusa6qXmVOZoKibmZeakKKalFmWWJJZllqcUK5ZklGQqJeYk56anFmckKiclA4cySSh4G1rTEnOJUXijNzaDg5hri7KGbWpAfn1pckJicmpdaEu8aYGhgZgnEjkbGRCgBAFrcMng</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>Dimethyl-(3-aryl-but-3-enyl) amine derivatives with analgesic activity</title><source>esp@cenet</source><creator>BUSCHMANN, HELMUT HEINRICH ; FRIDERICHS, ELMAR JOSEF ; KOEGEL, BABETTE-YVONNE ; STRASSBURGER, WOLFGANG WERNER ALFRED, -DR</creator><creatorcontrib>BUSCHMANN, HELMUT HEINRICH ; FRIDERICHS, ELMAR JOSEF ; KOEGEL, BABETTE-YVONNE ; STRASSBURGER, WOLFGANG WERNER ALFRED, -DR</creatorcontrib><description>Es werden Dimethyl-(3-aryl-but-3-enyl)-aminverbindungen der allgemeinen Formel 1, Verfahren zu deren Herstellung sowie die Verwendung dieser Verbindungen als pharmazeutische Wirkstoffe beschrieben. in der R C1-5-Alkyl ist und R H oder C-1-5-Alkyl bedeutet oder R und R zusammen -(CH2)2-4-, -(CH2)2-CHR oder -CH2-CHR -CH2- darstellen, R H oder C1-5-Alkyl bedeutet, R H, OH, C1-4-Alkyl, O-C1-4-Alkyl, O-Benzyl, CF3, O-CF3, Cl, F oder OR bedeutet, R H, OH, C1-4-Alkyl, O-C1-4-Alkyl, O-Benzyl, CHF2, CF3, O-CF3, Cl, F oder OR darstellt und R H, OH, C1-4-Alkyl, O-C1-4-Alkyl, O-Benzyl, CF3, O-CF3, Cl, F oder OR bedeutet, mit der Maßgabe, daß zwei der Reste R , R oder R H sind, oder R und R zusammen -CH=C(R )-O- oder -CH=C(R )-S- bedeuten, mit der Maßgabe, daß R H ist, oder R und R zusammen -CH=CH-C(OR )=CH- bedeuten, mit der Maßgabe, daß R H ist.
Dimethyl-(3-aryl-but-3-enyl)amine compounds of formula (I) and their salts, as enantiomers or racemates, are new. R1 = 1-5C alkyl; R2, R3 = H or 1-5C alkyl; or R1+R2 = (CH2)2, (CH2)3, (CH2)4, (CH2)2CHR7 or CH2-CHR7-CH2; R4, R6 = H, OH, 1-4C alkyl, 1-4C alkoxy, benzyloxy, CF3, OCF3, Cl, F or OR8; R5 = CHF2 or as for R4; provided that two of R4-R6 = H; or R4 = H and R5+R6 = CH=CH-C(OR10)=CH; or R4+R5 = CH=C(R9)-O and R6 = H; R7 = 1-8C alkyl, 3-8C cycloalkyl, 1-4C alkoxy, benzyloxy, CF3, Cl or F; R8 = phenyl, pyridyl, thienyl, thiazolyl (all optionally substituted), CO-T or PO(OR)2; T = 1-5C alkyl, 1-5C alkoxy, C6H4-R11, CHR12-NHR13 or NH-C6H3(R14)2; R = 1-4C alkyl; R9 = H or 1-4C alkyl; R10 = H or 1-3C alkyl; R11 = (1-3C alkyl)carbonyloxy in the o-position, or CH2N(R15)2 in the m- or p- position; R12, R13 = H, 1-6C alkyl or 3-8C cycloalkyl; or R12+R13 = (CH2)n; n = 3-8; R14 = independently H, OH, 1-7C alkyl , 1-7C alkoxy, phenyl, aryloxy, CF3, Cl or F; R15 = R; or N(R15)2 = morpholino; provided that the racemate (I; R1+R2 = (CH2)3; R3, R4, R6 = H; R5 = OMe) is excluded.</description><edition>7</edition><language>eng ; fre ; ger</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM ; CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2001</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20010117&DB=EPODOC&CC=EP&NR=1069106A2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20010117&DB=EPODOC&CC=EP&NR=1069106A2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>BUSCHMANN, HELMUT HEINRICH</creatorcontrib><creatorcontrib>FRIDERICHS, ELMAR JOSEF</creatorcontrib><creatorcontrib>KOEGEL, BABETTE-YVONNE</creatorcontrib><creatorcontrib>STRASSBURGER, WOLFGANG WERNER ALFRED, -DR</creatorcontrib><title>Dimethyl-(3-aryl-but-3-enyl) amine derivatives with analgesic activity</title><description>Es werden Dimethyl-(3-aryl-but-3-enyl)-aminverbindungen der allgemeinen Formel 1, Verfahren zu deren Herstellung sowie die Verwendung dieser Verbindungen als pharmazeutische Wirkstoffe beschrieben. in der R C1-5-Alkyl ist und R H oder C-1-5-Alkyl bedeutet oder R und R zusammen -(CH2)2-4-, -(CH2)2-CHR oder -CH2-CHR -CH2- darstellen, R H oder C1-5-Alkyl bedeutet, R H, OH, C1-4-Alkyl, O-C1-4-Alkyl, O-Benzyl, CF3, O-CF3, Cl, F oder OR bedeutet, R H, OH, C1-4-Alkyl, O-C1-4-Alkyl, O-Benzyl, CHF2, CF3, O-CF3, Cl, F oder OR darstellt und R H, OH, C1-4-Alkyl, O-C1-4-Alkyl, O-Benzyl, CF3, O-CF3, Cl, F oder OR bedeutet, mit der Maßgabe, daß zwei der Reste R , R oder R H sind, oder R und R zusammen -CH=C(R )-O- oder -CH=C(R )-S- bedeuten, mit der Maßgabe, daß R H ist, oder R und R zusammen -CH=CH-C(OR )=CH- bedeuten, mit der Maßgabe, daß R H ist.
Dimethyl-(3-aryl-but-3-enyl)amine compounds of formula (I) and their salts, as enantiomers or racemates, are new. R1 = 1-5C alkyl; R2, R3 = H or 1-5C alkyl; or R1+R2 = (CH2)2, (CH2)3, (CH2)4, (CH2)2CHR7 or CH2-CHR7-CH2; R4, R6 = H, OH, 1-4C alkyl, 1-4C alkoxy, benzyloxy, CF3, OCF3, Cl, F or OR8; R5 = CHF2 or as for R4; provided that two of R4-R6 = H; or R4 = H and R5+R6 = CH=CH-C(OR10)=CH; or R4+R5 = CH=C(R9)-O and R6 = H; R7 = 1-8C alkyl, 3-8C cycloalkyl, 1-4C alkoxy, benzyloxy, CF3, Cl or F; R8 = phenyl, pyridyl, thienyl, thiazolyl (all optionally substituted), CO-T or PO(OR)2; T = 1-5C alkyl, 1-5C alkoxy, C6H4-R11, CHR12-NHR13 or NH-C6H3(R14)2; R = 1-4C alkyl; R9 = H or 1-4C alkyl; R10 = H or 1-3C alkyl; R11 = (1-3C alkyl)carbonyloxy in the o-position, or CH2N(R15)2 in the m- or p- position; R12, R13 = H, 1-6C alkyl or 3-8C cycloalkyl; or R12+R13 = (CH2)n; n = 3-8; R14 = independently H, OH, 1-7C alkyl , 1-7C alkoxy, phenyl, aryloxy, CF3, Cl or F; R15 = R; or N(R15)2 = morpholino; provided that the racemate (I; R1+R2 = (CH2)3; R3, R4, R6 = H; R5 = OMe) is excluded.</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM</subject><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2001</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZHBzycxNLcmozNHVMNZNLALSSaUlusa6qXmVOZoKibmZeakKKalFmWWJJZllqcUK5ZklGQqJeYk56anFmckKiclA4cySSh4G1rTEnOJUXijNzaDg5hri7KGbWpAfn1pckJicmpdaEu8aYGhgZgnEjkbGRCgBAFrcMng</recordid><startdate>20010117</startdate><enddate>20010117</enddate><creator>BUSCHMANN, HELMUT HEINRICH</creator><creator>FRIDERICHS, ELMAR JOSEF</creator><creator>KOEGEL, BABETTE-YVONNE</creator><creator>STRASSBURGER, WOLFGANG WERNER ALFRED, -DR</creator><scope>EVB</scope></search><sort><creationdate>20010117</creationdate><title>Dimethyl-(3-aryl-but-3-enyl) amine derivatives with analgesic activity</title><author>BUSCHMANN, HELMUT HEINRICH ; FRIDERICHS, ELMAR JOSEF ; KOEGEL, BABETTE-YVONNE ; STRASSBURGER, WOLFGANG WERNER ALFRED, -DR</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_EP1069106A23</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre ; ger</language><creationdate>2001</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM</topic><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>BUSCHMANN, HELMUT HEINRICH</creatorcontrib><creatorcontrib>FRIDERICHS, ELMAR JOSEF</creatorcontrib><creatorcontrib>KOEGEL, BABETTE-YVONNE</creatorcontrib><creatorcontrib>STRASSBURGER, WOLFGANG WERNER ALFRED, -DR</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>BUSCHMANN, HELMUT HEINRICH</au><au>FRIDERICHS, ELMAR JOSEF</au><au>KOEGEL, BABETTE-YVONNE</au><au>STRASSBURGER, WOLFGANG WERNER ALFRED, -DR</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Dimethyl-(3-aryl-but-3-enyl) amine derivatives with analgesic activity</title><date>2001-01-17</date><risdate>2001</risdate><abstract>Es werden Dimethyl-(3-aryl-but-3-enyl)-aminverbindungen der allgemeinen Formel 1, Verfahren zu deren Herstellung sowie die Verwendung dieser Verbindungen als pharmazeutische Wirkstoffe beschrieben. in der R C1-5-Alkyl ist und R H oder C-1-5-Alkyl bedeutet oder R und R zusammen -(CH2)2-4-, -(CH2)2-CHR oder -CH2-CHR -CH2- darstellen, R H oder C1-5-Alkyl bedeutet, R H, OH, C1-4-Alkyl, O-C1-4-Alkyl, O-Benzyl, CF3, O-CF3, Cl, F oder OR bedeutet, R H, OH, C1-4-Alkyl, O-C1-4-Alkyl, O-Benzyl, CHF2, CF3, O-CF3, Cl, F oder OR darstellt und R H, OH, C1-4-Alkyl, O-C1-4-Alkyl, O-Benzyl, CF3, O-CF3, Cl, F oder OR bedeutet, mit der Maßgabe, daß zwei der Reste R , R oder R H sind, oder R und R zusammen -CH=C(R )-O- oder -CH=C(R )-S- bedeuten, mit der Maßgabe, daß R H ist, oder R und R zusammen -CH=CH-C(OR )=CH- bedeuten, mit der Maßgabe, daß R H ist.
Dimethyl-(3-aryl-but-3-enyl)amine compounds of formula (I) and their salts, as enantiomers or racemates, are new. R1 = 1-5C alkyl; R2, R3 = H or 1-5C alkyl; or R1+R2 = (CH2)2, (CH2)3, (CH2)4, (CH2)2CHR7 or CH2-CHR7-CH2; R4, R6 = H, OH, 1-4C alkyl, 1-4C alkoxy, benzyloxy, CF3, OCF3, Cl, F or OR8; R5 = CHF2 or as for R4; provided that two of R4-R6 = H; or R4 = H and R5+R6 = CH=CH-C(OR10)=CH; or R4+R5 = CH=C(R9)-O and R6 = H; R7 = 1-8C alkyl, 3-8C cycloalkyl, 1-4C alkoxy, benzyloxy, CF3, Cl or F; R8 = phenyl, pyridyl, thienyl, thiazolyl (all optionally substituted), CO-T or PO(OR)2; T = 1-5C alkyl, 1-5C alkoxy, C6H4-R11, CHR12-NHR13 or NH-C6H3(R14)2; R = 1-4C alkyl; R9 = H or 1-4C alkyl; R10 = H or 1-3C alkyl; R11 = (1-3C alkyl)carbonyloxy in the o-position, or CH2N(R15)2 in the m- or p- position; R12, R13 = H, 1-6C alkyl or 3-8C cycloalkyl; or R12+R13 = (CH2)n; n = 3-8; R14 = independently H, OH, 1-7C alkyl , 1-7C alkoxy, phenyl, aryloxy, CF3, Cl or F; R15 = R; or N(R15)2 = morpholino; provided that the racemate (I; R1+R2 = (CH2)3; R3, R4, R6 = H; R5 = OMe) is excluded.</abstract><edition>7</edition><oa>free_for_read</oa></addata></record> |
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| subjects | ACYCLIC OR CARBOCYCLIC COMPOUNDS ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Dimethyl-(3-aryl-but-3-enyl) amine derivatives with analgesic activity |
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