MAGNETICALLY RESPONSIVE COMPOSITION

MAGNETICALLY RESPONSIVE COMPOSITION

A magnetically controllable, or guided, carrier composition and methods of use and production are disclosed, the composition for carrying biologically active substances to a treatment zone in a body under control of a magnetic field. The composition comprises composite, volume-compounded paclitaxel-...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: CHERNYAKOV, SERGEI, V, ALLEN, LARRY, M, VOLKONSKY, VIKTOR, A, KENT, THOMAS, B, DYUKHSHERSTNOV, SERGEI, D
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page
container_issue
container_start_page
container_title
container_volume
creator CHERNYAKOV, SERGEI, V
ALLEN, LARRY, M
VOLKONSKY, VIKTOR, A
KENT, THOMAS, B
DYUKHSHERSTNOV, SERGEI, D
description A magnetically controllable, or guided, carrier composition and methods of use and production are disclosed, the composition for carrying biologically active substances to a treatment zone in a body under control of a magnetic field. The composition comprises composite, volume-compounded paclitaxel-adsorbed particles of 0.2 to 5.0 mum in size, and preferably between 0.5 and 5.0 mum, containing 1.0 to 95.0% by mass of carbon, and preferably from about 20% to about 60%. The particles are produced by mechanical milling of a mixture of iron and carbon powders. The obtained particles are placed in a solution of a biologically active substance to adsorb the substance onto the particles. The composition is generally administered in suspension. Magnetic carrier particles having therapeutic quantities of adsorbed paclitaxel, doxorubicin, Tc99, and antisense-C Myc oligonucleotide, an hematoporphyrin derivative, 6-mercaptopurine, Amphotericin B, and Camptothecin have been produced using this invention. Magnetic carrier particles having diagnostic quantities of adsorbed Re186 and Re188 have also been produced using this invention.
format Patent
fullrecord <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_EP1043975A1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>EP1043975A1</sourcerecordid><originalsourceid>FETCH-epo_espacenet_EP1043975A13</originalsourceid><addsrcrecordid>eNrjZFD2dXT3cw3xdHb08YlUCHINDvD3C_YMc1Vw9vcN8A_2DPH09-NhYE1LzClO5YXS3AwKbq4hzh66qQX58anFBYnJqXmpJfGuAYYGJsaW5qaOhsZEKAEARK4iyA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>MAGNETICALLY RESPONSIVE COMPOSITION</title><source>esp@cenet</source><creator>CHERNYAKOV, SERGEI, V ; ALLEN, LARRY, M ; VOLKONSKY, VIKTOR, A ; KENT, THOMAS, B ; DYUKHSHERSTNOV, SERGEI, D</creator><creatorcontrib>CHERNYAKOV, SERGEI, V ; ALLEN, LARRY, M ; VOLKONSKY, VIKTOR, A ; KENT, THOMAS, B ; DYUKHSHERSTNOV, SERGEI, D</creatorcontrib><description>A magnetically controllable, or guided, carrier composition and methods of use and production are disclosed, the composition for carrying biologically active substances to a treatment zone in a body under control of a magnetic field. The composition comprises composite, volume-compounded paclitaxel-adsorbed particles of 0.2 to 5.0 mum in size, and preferably between 0.5 and 5.0 mum, containing 1.0 to 95.0% by mass of carbon, and preferably from about 20% to about 60%. The particles are produced by mechanical milling of a mixture of iron and carbon powders. The obtained particles are placed in a solution of a biologically active substance to adsorb the substance onto the particles. The composition is generally administered in suspension. Magnetic carrier particles having therapeutic quantities of adsorbed paclitaxel, doxorubicin, Tc99, and antisense-C Myc oligonucleotide, an hematoporphyrin derivative, 6-mercaptopurine, Amphotericin B, and Camptothecin have been produced using this invention. Magnetic carrier particles having diagnostic quantities of adsorbed Re186 and Re188 have also been produced using this invention.</description><edition>7</edition><language>eng ; fre ; ger</language><subject>HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2000</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&amp;date=20001018&amp;DB=EPODOC&amp;CC=EP&amp;NR=1043975A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&amp;date=20001018&amp;DB=EPODOC&amp;CC=EP&amp;NR=1043975A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>CHERNYAKOV, SERGEI, V</creatorcontrib><creatorcontrib>ALLEN, LARRY, M</creatorcontrib><creatorcontrib>VOLKONSKY, VIKTOR, A</creatorcontrib><creatorcontrib>KENT, THOMAS, B</creatorcontrib><creatorcontrib>DYUKHSHERSTNOV, SERGEI, D</creatorcontrib><title>MAGNETICALLY RESPONSIVE COMPOSITION</title><description>A magnetically controllable, or guided, carrier composition and methods of use and production are disclosed, the composition for carrying biologically active substances to a treatment zone in a body under control of a magnetic field. The composition comprises composite, volume-compounded paclitaxel-adsorbed particles of 0.2 to 5.0 mum in size, and preferably between 0.5 and 5.0 mum, containing 1.0 to 95.0% by mass of carbon, and preferably from about 20% to about 60%. The particles are produced by mechanical milling of a mixture of iron and carbon powders. The obtained particles are placed in a solution of a biologically active substance to adsorb the substance onto the particles. The composition is generally administered in suspension. Magnetic carrier particles having therapeutic quantities of adsorbed paclitaxel, doxorubicin, Tc99, and antisense-C Myc oligonucleotide, an hematoporphyrin derivative, 6-mercaptopurine, Amphotericin B, and Camptothecin have been produced using this invention. Magnetic carrier particles having diagnostic quantities of adsorbed Re186 and Re188 have also been produced using this invention.</description><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2000</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZFD2dXT3cw3xdHb08YlUCHINDvD3C_YMc1Vw9vcN8A_2DPH09-NhYE1LzClO5YXS3AwKbq4hzh66qQX58anFBYnJqXmpJfGuAYYGJsaW5qaOhsZEKAEARK4iyA</recordid><startdate>20001018</startdate><enddate>20001018</enddate><creator>CHERNYAKOV, SERGEI, V</creator><creator>ALLEN, LARRY, M</creator><creator>VOLKONSKY, VIKTOR, A</creator><creator>KENT, THOMAS, B</creator><creator>DYUKHSHERSTNOV, SERGEI, D</creator><scope>EVB</scope></search><sort><creationdate>20001018</creationdate><title>MAGNETICALLY RESPONSIVE COMPOSITION</title><author>CHERNYAKOV, SERGEI, V ; ALLEN, LARRY, M ; VOLKONSKY, VIKTOR, A ; KENT, THOMAS, B ; DYUKHSHERSTNOV, SERGEI, D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_EP1043975A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre ; ger</language><creationdate>2000</creationdate><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>CHERNYAKOV, SERGEI, V</creatorcontrib><creatorcontrib>ALLEN, LARRY, M</creatorcontrib><creatorcontrib>VOLKONSKY, VIKTOR, A</creatorcontrib><creatorcontrib>KENT, THOMAS, B</creatorcontrib><creatorcontrib>DYUKHSHERSTNOV, SERGEI, D</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>CHERNYAKOV, SERGEI, V</au><au>ALLEN, LARRY, M</au><au>VOLKONSKY, VIKTOR, A</au><au>KENT, THOMAS, B</au><au>DYUKHSHERSTNOV, SERGEI, D</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>MAGNETICALLY RESPONSIVE COMPOSITION</title><date>2000-10-18</date><risdate>2000</risdate><abstract>A magnetically controllable, or guided, carrier composition and methods of use and production are disclosed, the composition for carrying biologically active substances to a treatment zone in a body under control of a magnetic field. The composition comprises composite, volume-compounded paclitaxel-adsorbed particles of 0.2 to 5.0 mum in size, and preferably between 0.5 and 5.0 mum, containing 1.0 to 95.0% by mass of carbon, and preferably from about 20% to about 60%. The particles are produced by mechanical milling of a mixture of iron and carbon powders. The obtained particles are placed in a solution of a biologically active substance to adsorb the substance onto the particles. The composition is generally administered in suspension. Magnetic carrier particles having therapeutic quantities of adsorbed paclitaxel, doxorubicin, Tc99, and antisense-C Myc oligonucleotide, an hematoporphyrin derivative, 6-mercaptopurine, Amphotericin B, and Camptothecin have been produced using this invention. Magnetic carrier particles having diagnostic quantities of adsorbed Re186 and Re188 have also been produced using this invention.</abstract><edition>7</edition><oa>free_for_read</oa></addata></record>
fulltext fulltext_linktorsrc
identifier
ispartof
issn
language eng ; fre ; ger
recordid cdi_epo_espacenet_EP1043975A1
source esp@cenet
subjects HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title MAGNETICALLY RESPONSIVE COMPOSITION
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-03T08%3A33%3A37IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=CHERNYAKOV,%20SERGEI,%20V&rft.date=2000-10-18&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3EEP1043975A1%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true