PROCESS FOR SYNTHESIZING CARBAPENEM SIDE CHAIN INTERMEDIATES

PROCESS FOR SYNTHESIZING CARBAPENEM SIDE CHAIN INTERMEDIATES

A process of synthesizing a compound of formula (1) is described. A compound of formula (2) is reacted with diphenylphosphinic chloride to activate the carboxylic acid group, and then reacted with methanesulfonyl chloride to produce a compound of formula (4). Compound (4) is then reacted with a grou...

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Hauptverfasser: BRANDS, KAREL, M., J, DOLLING, ULF, H, CAMERON, MARK, JOBSON, RONALD, B, ASHWOOD, MICHAEL, S, WILLIAMS, JOHN, M, COTTRELL, IAN, F, DAVIES, ANTHONY, J
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Sprache:eng ; fre ; ger
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ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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creator BRANDS, KAREL, M., J
DOLLING, ULF, H
CAMERON, MARK
JOBSON, RONALD, B
ASHWOOD, MICHAEL, S
WILLIAMS, JOHN, M
COTTRELL, IAN, F
DAVIES, ANTHONY, J
description A process of synthesizing a compound of formula (1) is described. A compound of formula (2) is reacted with diphenylphosphinic chloride to activate the carboxylic acid group, and then reacted with methanesulfonyl chloride to produce a compound of formula (4). Compound (4) is then reacted with a group II metal sulfide source in water to produce a compound of formula (1).
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A compound of formula (2) is reacted with diphenylphosphinic chloride to activate the carboxylic acid group, and then reacted with methanesulfonyl chloride to produce a compound of formula (4). Compound (4) is then reacted with a group II metal sulfide source in water to produce a compound of formula (1).</abstract><edition>7</edition><oa>free_for_read</oa></addata></record>
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subjects ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
title PROCESS FOR SYNTHESIZING CARBAPENEM SIDE CHAIN INTERMEDIATES
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