Stem cell factor

Non-naturally occurring polypeptide (I) is claimed, whose aminoacid sequence is similar enough to naturally-occurring stem cell factor (SCF) to give it the same haematopoietic biological activity. (I) is produced by eukaryotic or prokaryotic expression of an exogeneous DNA sequence, and has in vivo...

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Bibliographische Detailangaben
Hauptverfasser:	SUGGS, SIDNEY VAUGHN, BOSSELMANN, ROBERT A, ZSEBO, KRISZTINA M, MARTIN, FRANCIS HALL
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES USING MICROORGANISMS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	Non-naturally occurring polypeptide (I) is claimed, whose aminoacid sequence is similar enough to naturally-occurring stem cell factor (SCF) to give it the same haematopoietic biological activity. (I) is produced by eukaryotic or prokaryotic expression of an exogeneous DNA sequence, and has in vivo and in vitro biological activity. Also claimed are a DNA sequence encoding (I), a host transformed with the DNA sequence, a process for producing and recoverng SCF, a DNA sequence encoding a human SCF analogue, an antibody that binds SCF, a compsn.; of (I) with a water-soluble polymer, a method of preparing the above compsn. and a method of transfecting early haematopoietic stem cells. Routes of administration are e.g. parenteral, pulmonary, nasal and oral.