CONSTRAINED HELICAL PEPTIDES AND METHODS OF MAKING SAME

Provided are cyclized peptides with a constrained region(s) having an alpha -helical conformation. Constrained helical peptides having amino acid sequences from HIV gp41 are provided, as is their use in preparing antibodies that prevent viral membrane fusion. Also provided are methods for making suc...

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Hauptverfasser:	BRAISTED, ANDREW, WELLS, JAMES, A, STAROVASNIK, MELISSA, A, PHELAN, J., CHRISTOPHER, JUDICE, J., KEVIN, MCDOWELL, ROBERT, S
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Sprache:	eng ; fre ; ger
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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creator	BRAISTED, ANDREW WELLS, JAMES, A STAROVASNIK, MELISSA, A PHELAN, J., CHRISTOPHER JUDICE, J., KEVIN MCDOWELL, ROBERT, S
description	Provided are cyclized peptides with a constrained region(s) having an alpha -helical conformation. Constrained helical peptides having amino acid sequences from HIV gp41 are provided, as is their use in preparing antibodies that prevent viral membrane fusion. Also provided are methods for making such cyclized peptides.
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subjects	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title	CONSTRAINED HELICAL PEPTIDES AND METHODS OF MAKING SAME
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