Process for the determination of a dosing regimen for thrombin inhibitors
A method for determining a dosing regimen for hirudin or oral thrombin inhibitors, comprises: (a) administering a standard dose of hirudin or oral thrombin inhibitor; (b) testing the hirudin or oral thrombin inhibitor concentration using ecarin-clotting-time test; and (c) determining the standard do...
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| creator | KREIS, SIEGFRIED NOERTERSHEUSER, PETER DR |
| description | A method for determining a dosing regimen for hirudin or oral thrombin inhibitors, comprises: (a) administering a standard dose of hirudin or oral thrombin inhibitor; (b) testing the hirudin or oral thrombin inhibitor concentration using ecarin-clotting-time test; and (c) determining the standard dose ratio to the result of the ecarin-clotting-time-test using a computer program, e.g. p-PHARM 1.4, SIMED, 1996, based on pharmaco-kinetic/pharmaco-dynamic models, to determine the follow-up dosages of hirudin or oral thrombin inhibitors. An Independent claim is also included for the use of hirudin or oral thrombin inhibitors in the preparation of a medicament for the treatment or prevention of thromboembolisms according to a treatment plan, comprising: (a) administering a standard hirudin or oral thrombin inhibitor dose; (b) establishing ecarin-clotting-time; and (c) administering a second dose of hirudin or oral thrombin inhibitor which has been established using the computer program as described above. |
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An Independent claim is also included for the use of hirudin or oral thrombin inhibitors in the preparation of a medicament for the treatment or prevention of thromboembolisms according to a treatment plan, comprising: (a) administering a standard hirudin or oral thrombin inhibitor dose; (b) establishing ecarin-clotting-time; and (c) administering a second dose of hirudin or oral thrombin inhibitor which has been established using the computer program as described above.</description><language>eng ; fre ; ger</language><subject>BEER ; BIOCHEMISTRY ; CALCULATING ; CHEMISTRY ; COMPOSITIONS THEREOF ; COMPUTING ; COUNTING ; CULTURE MEDIA ; ELECTRIC DIGITAL DATA PROCESSING ; ENZYMOLOGY ; HUMAN NECESSITIES ; HYGIENE ; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES ; MEASURING ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; ORGANIC CHEMISTRY ; PEPTIDES ; PHYSICS ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; SPIRITS ; TESTING ; VINEGAR ; WINE</subject><creationdate>2006</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20060104&DB=EPODOC&CC=EP&NR=0924519B1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,778,883,25547,76298</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20060104&DB=EPODOC&CC=EP&NR=0924519B1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>KREIS, SIEGFRIED</creatorcontrib><creatorcontrib>NOERTERSHEUSER, PETER DR</creatorcontrib><title>Process for the determination of a dosing regimen for thrombin inhibitors</title><description>A method for determining a dosing regimen for hirudin or oral thrombin inhibitors, comprises: (a) administering a standard dose of hirudin or oral thrombin inhibitor; (b) testing the hirudin or oral thrombin inhibitor concentration using ecarin-clotting-time test; and (c) determining the standard dose ratio to the result of the ecarin-clotting-time-test using a computer program, e.g. p-PHARM 1.4, SIMED, 1996, based on pharmaco-kinetic/pharmaco-dynamic models, to determine the follow-up dosages of hirudin or oral thrombin inhibitors. 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An Independent claim is also included for the use of hirudin or oral thrombin inhibitors in the preparation of a medicament for the treatment or prevention of thromboembolisms according to a treatment plan, comprising: (a) administering a standard hirudin or oral thrombin inhibitor dose; (b) establishing ecarin-clotting-time; and (c) administering a second dose of hirudin or oral thrombin inhibitor which has been established using the computer program as described above.</abstract><oa>free_for_read</oa></addata></record> |
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| language | eng ; fre ; ger |
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| subjects | BEER BIOCHEMISTRY CALCULATING CHEMISTRY COMPOSITIONS THEREOF COMPUTING COUNTING CULTURE MEDIA ELECTRIC DIGITAL DATA PROCESSING ENZYMOLOGY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TESTING VINEGAR WINE |
| title | Process for the determination of a dosing regimen for thrombin inhibitors |
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