INDOL DERIVATIVES USEFUL FOR THE TREATMENT OF MIGRAINE, COMPOSITION AND UTILIZATION
Indole derivatives having the Formula (I) wherein R1 is H, alkyl or acyl group; R2 is H, halogen or alkyl, hydroxy, alkoxy; ciano, carboxamide, carboxyl, alkoxicarbonyl, phenyl, phenyloxy or a group -(CH2)n-R6, (n=1-3), and R6 is a group ciano, nitro, phenyl, carboxyl, -CO2R7; -CONR7R8; -SO2NR7R8; -...
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| creator | DEL CASTILLO NIETO, JUAN CARLOS ROCA ACIN, JUAN GIMENEZ GUASCH, FERNANDO CALDERO GES, JOSE MARIA BOSCH ROVIRA, ANNA MARQUILLAS OLONDRIZ, FRANCISCO DALMASES BARJOAN, PEDRO HUGUET CLOTET, JUAN |
| description | Indole derivatives having the Formula (I) wherein R1 is H, alkyl or acyl group; R2 is H, halogen or alkyl, hydroxy, alkoxy; ciano, carboxamide, carboxyl, alkoxicarbonyl, phenyl, phenyloxy or a group -(CH2)n-R6, (n=1-3), and R6 is a group ciano, nitro, phenyl, carboxyl, -CO2R7; -CONR7R8; -SO2NR7R8; -COR7; -SO2R7, R7 and R8 being H or alkyl; R7 and R8, together with N, can form a cycle of 4-7 links; R3, R4 and R5 are H, halogen or a group alkyl, phenyl, substituted phenyl, hydroxy, alcoxy, phenyloxy or benziloxy; NR11R12 is H or a group ciano, nitro, carboxyl, alcoxycarbonyl, carboxamido or a group R3; A is an alkyliden group -(CH2)-m, (m = 1-5), or alkenyl group; B is a piperazinoring (a), aminopyrrolidinoring (b); pyrrolidinamino ring (c); piperidinoring (d) or ethylendiamino -NR9-CH2-CH2-NR10-, R9 and R10 being H or an alkyl group. The compounds are useful for the treatment of migraine. |
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The compounds are useful for the treatment of migraine.</description><edition>6</edition><language>eng ; fre ; ger</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>1996</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19960605&DB=EPODOC&CC=EP&NR=0714896A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19960605&DB=EPODOC&CC=EP&NR=0714896A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>DEL CASTILLO NIETO, JUAN CARLOS</creatorcontrib><creatorcontrib>ROCA ACIN, JUAN</creatorcontrib><creatorcontrib>GIMENEZ GUASCH, FERNANDO</creatorcontrib><creatorcontrib>CALDERO GES, JOSE MARIA</creatorcontrib><creatorcontrib>BOSCH ROVIRA, ANNA</creatorcontrib><creatorcontrib>MARQUILLAS OLONDRIZ, FRANCISCO</creatorcontrib><creatorcontrib>DALMASES BARJOAN, PEDRO</creatorcontrib><creatorcontrib>HUGUET CLOTET, JUAN</creatorcontrib><title>INDOL DERIVATIVES USEFUL FOR THE TREATMENT OF MIGRAINE, COMPOSITION AND UTILIZATION</title><description>Indole derivatives having the Formula (I) wherein R1 is H, alkyl or acyl group; R2 is H, halogen or alkyl, hydroxy, alkoxy; ciano, carboxamide, carboxyl, alkoxicarbonyl, phenyl, phenyloxy or a group -(CH2)n-R6, (n=1-3), and R6 is a group ciano, nitro, phenyl, carboxyl, -CO2R7; -CONR7R8; -SO2NR7R8; -COR7; -SO2R7, R7 and R8 being H or alkyl; R7 and R8, together with N, can form a cycle of 4-7 links; R3, R4 and R5 are H, halogen or a group alkyl, phenyl, substituted phenyl, hydroxy, alcoxy, phenyloxy or benziloxy; NR11R12 is H or a group ciano, nitro, carboxyl, alcoxycarbonyl, carboxamido or a group R3; A is an alkyliden group -(CH2)-m, (m = 1-5), or alkenyl group; B is a piperazinoring (a), aminopyrrolidinoring (b); pyrrolidinamino ring (c); piperidinoring (d) or ethylendiamino -NR9-CH2-CH2-NR10-, R9 and R10 being H or an alkyl group. The compounds are useful for the treatment of migraine.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1996</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNyk0KwjAQQOFsXIh6hzmAgkXxZxmaiR1IMiWZdOGmFIkr0UK9PyJ4AFePD95cJQqGHRiM1GmhDhPkhDY7sBxBGgSJqMVjEGALni5RU8A11OxbTiTEAXQwkIUcXfXXSzW7D4-prH5dKLAodbMp46sv0zjcyrO8e2y3x2p_Oh90tftj-QC-9i_E</recordid><startdate>19960605</startdate><enddate>19960605</enddate><creator>DEL CASTILLO NIETO, JUAN CARLOS</creator><creator>ROCA ACIN, JUAN</creator><creator>GIMENEZ GUASCH, FERNANDO</creator><creator>CALDERO GES, JOSE MARIA</creator><creator>BOSCH ROVIRA, ANNA</creator><creator>MARQUILLAS OLONDRIZ, FRANCISCO</creator><creator>DALMASES BARJOAN, PEDRO</creator><creator>HUGUET CLOTET, JUAN</creator><scope>EVB</scope></search><sort><creationdate>19960605</creationdate><title>INDOL DERIVATIVES USEFUL FOR THE TREATMENT OF MIGRAINE, COMPOSITION AND UTILIZATION</title><author>DEL CASTILLO NIETO, JUAN CARLOS ; ROCA ACIN, JUAN ; GIMENEZ GUASCH, FERNANDO ; CALDERO GES, JOSE MARIA ; BOSCH ROVIRA, ANNA ; MARQUILLAS OLONDRIZ, FRANCISCO ; DALMASES BARJOAN, PEDRO ; HUGUET CLOTET, JUAN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_EP0714896A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre ; ger</language><creationdate>1996</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>DEL CASTILLO NIETO, JUAN CARLOS</creatorcontrib><creatorcontrib>ROCA ACIN, JUAN</creatorcontrib><creatorcontrib>GIMENEZ GUASCH, FERNANDO</creatorcontrib><creatorcontrib>CALDERO GES, JOSE MARIA</creatorcontrib><creatorcontrib>BOSCH ROVIRA, ANNA</creatorcontrib><creatorcontrib>MARQUILLAS OLONDRIZ, FRANCISCO</creatorcontrib><creatorcontrib>DALMASES BARJOAN, PEDRO</creatorcontrib><creatorcontrib>HUGUET CLOTET, JUAN</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>DEL CASTILLO NIETO, JUAN CARLOS</au><au>ROCA ACIN, JUAN</au><au>GIMENEZ GUASCH, FERNANDO</au><au>CALDERO GES, JOSE MARIA</au><au>BOSCH ROVIRA, ANNA</au><au>MARQUILLAS OLONDRIZ, FRANCISCO</au><au>DALMASES BARJOAN, PEDRO</au><au>HUGUET CLOTET, JUAN</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>INDOL DERIVATIVES USEFUL FOR THE TREATMENT OF MIGRAINE, COMPOSITION AND UTILIZATION</title><date>1996-06-05</date><risdate>1996</risdate><abstract>Indole derivatives having the Formula (I) wherein R1 is H, alkyl or acyl group; R2 is H, halogen or alkyl, hydroxy, alkoxy; ciano, carboxamide, carboxyl, alkoxicarbonyl, phenyl, phenyloxy or a group -(CH2)n-R6, (n=1-3), and R6 is a group ciano, nitro, phenyl, carboxyl, -CO2R7; -CONR7R8; -SO2NR7R8; -COR7; -SO2R7, R7 and R8 being H or alkyl; R7 and R8, together with N, can form a cycle of 4-7 links; R3, R4 and R5 are H, halogen or a group alkyl, phenyl, substituted phenyl, hydroxy, alcoxy, phenyloxy or benziloxy; NR11R12 is H or a group ciano, nitro, carboxyl, alcoxycarbonyl, carboxamido or a group R3; A is an alkyliden group -(CH2)-m, (m = 1-5), or alkenyl group; B is a piperazinoring (a), aminopyrrolidinoring (b); pyrrolidinamino ring (c); piperidinoring (d) or ethylendiamino -NR9-CH2-CH2-NR10-, R9 and R10 being H or an alkyl group. The compounds are useful for the treatment of migraine.</abstract><edition>6</edition><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | INDOL DERIVATIVES USEFUL FOR THE TREATMENT OF MIGRAINE, COMPOSITION AND UTILIZATION |
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