2-, 3-, 4-, 5-, 6-, 7-, 8-, 9- AND/OR 10-SUBSTITUTED DIBENZOXAZEPINE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE

The present invention provides substituted dibenzoxazepine compounds of Formula I: Formula I wherein X is oxygen, sulfur A is -CH2- or E and F may be -CH, oxygen, nitrogen or sulfur, and may not be the same; G is oxygen, nitrogen or sulfur; with the proviso that when G is oxygen or sulfur, one of E...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	HAGEN, TIMOTHY, JOSEPH, HALLINAN, E., ANN, TSYMBALOV, SOFYA, PITZELE, BARNETT, SYLVAIN, CHANDRAKUMAR, NIZAL, SAMUEL
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

container_end_page
container_issue
container_start_page
container_title
container_volume
creator	HAGEN, TIMOTHY, JOSEPH HALLINAN, E., ANN TSYMBALOV, SOFYA PITZELE, BARNETT, SYLVAIN CHANDRAKUMAR, NIZAL, SAMUEL
description	The present invention provides substituted dibenzoxazepine compounds of Formula I: Formula I wherein X is oxygen, sulfur A is -CH2- or E and F may be -CH, oxygen, nitrogen or sulfur, and may not be the same; G is oxygen, nitrogen or sulfur; with the proviso that when G is oxygen or sulfur, one of E or F is nitrogen, which are useful as analgesic agents for the treatment of pain, and as prostaglandin-E2 antagonists for the treatment of prostaglandin-E2 mediated diseases, pharmaceutical compositions comprising a therapeutically-effective amount of a compound of Formula I in combination with a pharmaceutically-acceptable carrier, a method for eliminating or ameliorating pain in an animal, and a method for treating prostaglandin-E2 mediated diseases in an animal, comprising administering a therapeutically-effective amount of a compound of Formula I to the animal.
format	Patent
fullrecord	<record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_EP0696283B1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>EP0696283B1</sourcerecordid><originalsourceid>FETCH-epo_espacenet_EP0696283B13</originalsourceid><addsrcrecordid>eNqNzDEOgjAYBWAWB6Pe4T8AjSCKMJb2JzSRtqFtYlgIMXUySoKzZ7dGD-Dw5Q3v5S2j147EkAX74BDkwTEogpIAlXyrOkgTYlxlrLDOIgcuKpS9OtMetZAITLVaOclNDLqhXUsZOisYPX0bI6xQ0nzOoEXbKG5A1eAMrqPFdbzNfvPLVQQ1WtYQPz0GP0_jxd_9c0Cd5GW-K7Iqzf6YvAFAmDhy</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>2-, 3-, 4-, 5-, 6-, 7-, 8-, 9- AND/OR 10-SUBSTITUTED DIBENZOXAZEPINE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE</title><source>esp@cenet</source><creator>HAGEN, TIMOTHY, JOSEPH ; HALLINAN, E., ANN ; TSYMBALOV, SOFYA ; PITZELE, BARNETT, SYLVAIN ; CHANDRAKUMAR, NIZAL, SAMUEL</creator><creatorcontrib>HAGEN, TIMOTHY, JOSEPH ; HALLINAN, E., ANN ; TSYMBALOV, SOFYA ; PITZELE, BARNETT, SYLVAIN ; CHANDRAKUMAR, NIZAL, SAMUEL</creatorcontrib><description>The present invention provides substituted dibenzoxazepine compounds of Formula I: Formula I wherein X is oxygen, sulfur A is -CH2- or E and F may be -CH, oxygen, nitrogen or sulfur, and may not be the same; G is oxygen, nitrogen or sulfur; with the proviso that when G is oxygen or sulfur, one of E or F is nitrogen, which are useful as analgesic agents for the treatment of pain, and as prostaglandin-E2 antagonists for the treatment of prostaglandin-E2 mediated diseases, pharmaceutical compositions comprising a therapeutically-effective amount of a compound of Formula I in combination with a pharmaceutically-acceptable carrier, a method for eliminating or ameliorating pain in an animal, and a method for treating prostaglandin-E2 mediated diseases in an animal, comprising administering a therapeutically-effective amount of a compound of Formula I to the animal.</description><edition>6</edition><language>eng ; fre ; ger</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>1997</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19970917&DB=EPODOC&CC=EP&NR=0696283B1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25544,76293</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19970917&DB=EPODOC&CC=EP&NR=0696283B1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>HAGEN, TIMOTHY, JOSEPH</creatorcontrib><creatorcontrib>HALLINAN, E., ANN</creatorcontrib><creatorcontrib>TSYMBALOV, SOFYA</creatorcontrib><creatorcontrib>PITZELE, BARNETT, SYLVAIN</creatorcontrib><creatorcontrib>CHANDRAKUMAR, NIZAL, SAMUEL</creatorcontrib><title>2-, 3-, 4-, 5-, 6-, 7-, 8-, 9- AND/OR 10-SUBSTITUTED DIBENZOXAZEPINE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE</title><description>The present invention provides substituted dibenzoxazepine compounds of Formula I: Formula I wherein X is oxygen, sulfur A is -CH2- or E and F may be -CH, oxygen, nitrogen or sulfur, and may not be the same; G is oxygen, nitrogen or sulfur; with the proviso that when G is oxygen or sulfur, one of E or F is nitrogen, which are useful as analgesic agents for the treatment of pain, and as prostaglandin-E2 antagonists for the treatment of prostaglandin-E2 mediated diseases, pharmaceutical compositions comprising a therapeutically-effective amount of a compound of Formula I in combination with a pharmaceutically-acceptable carrier, a method for eliminating or ameliorating pain in an animal, and a method for treating prostaglandin-E2 mediated diseases in an animal, comprising administering a therapeutically-effective amount of a compound of Formula I to the animal.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1997</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNzDEOgjAYBWAWB6Pe4T8AjSCKMJb2JzSRtqFtYlgIMXUySoKzZ7dGD-Dw5Q3v5S2j147EkAX74BDkwTEogpIAlXyrOkgTYlxlrLDOIgcuKpS9OtMetZAITLVaOclNDLqhXUsZOisYPX0bI6xQ0nzOoEXbKG5A1eAMrqPFdbzNfvPLVQQ1WtYQPz0GP0_jxd_9c0Cd5GW-K7Iqzf6YvAFAmDhy</recordid><startdate>19970917</startdate><enddate>19970917</enddate><creator>HAGEN, TIMOTHY, JOSEPH</creator><creator>HALLINAN, E., ANN</creator><creator>TSYMBALOV, SOFYA</creator><creator>PITZELE, BARNETT, SYLVAIN</creator><creator>CHANDRAKUMAR, NIZAL, SAMUEL</creator><scope>EVB</scope></search><sort><creationdate>19970917</creationdate><title>2-, 3-, 4-, 5-, 6-, 7-, 8-, 9- AND/OR 10-SUBSTITUTED DIBENZOXAZEPINE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE</title><author>HAGEN, TIMOTHY, JOSEPH ; HALLINAN, E., ANN ; TSYMBALOV, SOFYA ; PITZELE, BARNETT, SYLVAIN ; CHANDRAKUMAR, NIZAL, SAMUEL</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_EP0696283B13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre ; ger</language><creationdate>1997</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>HAGEN, TIMOTHY, JOSEPH</creatorcontrib><creatorcontrib>HALLINAN, E., ANN</creatorcontrib><creatorcontrib>TSYMBALOV, SOFYA</creatorcontrib><creatorcontrib>PITZELE, BARNETT, SYLVAIN</creatorcontrib><creatorcontrib>CHANDRAKUMAR, NIZAL, SAMUEL</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>HAGEN, TIMOTHY, JOSEPH</au><au>HALLINAN, E., ANN</au><au>TSYMBALOV, SOFYA</au><au>PITZELE, BARNETT, SYLVAIN</au><au>CHANDRAKUMAR, NIZAL, SAMUEL</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>2-, 3-, 4-, 5-, 6-, 7-, 8-, 9- AND/OR 10-SUBSTITUTED DIBENZOXAZEPINE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE</title><date>1997-09-17</date><risdate>1997</risdate><abstract>The present invention provides substituted dibenzoxazepine compounds of Formula I: Formula I wherein X is oxygen, sulfur A is -CH2- or E and F may be -CH, oxygen, nitrogen or sulfur, and may not be the same; G is oxygen, nitrogen or sulfur; with the proviso that when G is oxygen or sulfur, one of E or F is nitrogen, which are useful as analgesic agents for the treatment of pain, and as prostaglandin-E2 antagonists for the treatment of prostaglandin-E2 mediated diseases, pharmaceutical compositions comprising a therapeutically-effective amount of a compound of Formula I in combination with a pharmaceutically-acceptable carrier, a method for eliminating or ameliorating pain in an animal, and a method for treating prostaglandin-E2 mediated diseases in an animal, comprising administering a therapeutically-effective amount of a compound of Formula I to the animal.</abstract><edition>6</edition><oa>free_for_read</oa></addata></record>
fulltext	fulltext_linktorsrc
identifier
ispartof
issn
language	eng ; fre ; ger
recordid	cdi_epo_espacenet_EP0696283B1
source	esp@cenet
subjects	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title	2-, 3-, 4-, 5-, 6-, 7-, 8-, 9- AND/OR 10-SUBSTITUTED DIBENZOXAZEPINE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE
url	https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-27T21%3A50%3A34IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=HAGEN,%20TIMOTHY,%20JOSEPH&rft.date=1997-09-17&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3EEP0696283B1%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true