NEW COMPOUNDS
The present invention relates to novel derivatives of 3-hydroxyanthranilic acid, 3-HANA, of the general formula I I wherein R1 and R2 are the same or different and selected from H, alkyl, aryl and arylalkyl; X and Y are the same or different and selected from alkoxy, aryloxy, alkyl, alkylthio, arylt...
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| creator | GOTTHAMMAR, KRISTINA, BRIGITTA LUTHMAN, PER, JOHAN BJOERK, SUSANNA, KARIN, MARIA PERSSON, KERSTIN, MARGARETA, IRMA LINDERBERG, MAT, TORBJOERN SCHWARCZ, ROBERT CARPENTIER, BARRY, K |
| description | The present invention relates to novel derivatives of 3-hydroxyanthranilic acid, 3-HANA, of the general formula I I wherein R1 and R2 are the same or different and selected from H, alkyl, aryl and arylalkyl; X and Y are the same or different and selected from alkoxy, aryloxy, alkyl, alkylthio, arylthio, fluoroalkyl, halogen, cyano, OSO2CH3, OSO2CF3, OCF3 and SCF3 with the proviso that the compound of formula I wherein R1 and R2=H, X=Br and Y=Me is excluded; or a pharmaceutically acceptable salt thereof, methods and intermediates for their preparation, novel pharmaceutical compositions and the use thereof for inhibiting the enzyme 3-hydroxyanthranilate oxygenase, 3-HAO, responsible for the production of the endogenous neurotoxin quinolinic acid, QUIN. |
| format | Patent |
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CARPENTIER, BARRY, K</creatorcontrib><description>The present invention relates to novel derivatives of 3-hydroxyanthranilic acid, 3-HANA, of the general formula I I wherein R1 and R2 are the same or different and selected from H, alkyl, aryl and arylalkyl; X and Y are the same or different and selected from alkoxy, aryloxy, alkyl, alkylthio, arylthio, fluoroalkyl, halogen, cyano, OSO2CH3, OSO2CF3, OCF3 and SCF3 with the proviso that the compound of formula I wherein R1 and R2=H, X=Br and Y=Me is excluded; or a pharmaceutically acceptable salt thereof, methods and intermediates for their preparation, novel pharmaceutical compositions and the use thereof for inhibiting the enzyme 3-hydroxyanthranilate oxygenase, 3-HAO, responsible for the production of the endogenous neurotoxin quinolinic acid, QUIN.</description><edition>6</edition><language>eng ; fre ; ger</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; 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X and Y are the same or different and selected from alkoxy, aryloxy, alkyl, alkylthio, arylthio, fluoroalkyl, halogen, cyano, OSO2CH3, OSO2CF3, OCF3 and SCF3 with the proviso that the compound of formula I wherein R1 and R2=H, X=Br and Y=Me is excluded; or a pharmaceutically acceptable salt thereof, methods and intermediates for their preparation, novel pharmaceutical compositions and the use thereof for inhibiting the enzyme 3-hydroxyanthranilate oxygenase, 3-HAO, responsible for the production of the endogenous neurotoxin quinolinic acid, QUIN.</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1995</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZOD1cw1XcPb3DfAP9XMJ5mFgTUvMKU7lhdLcDApuriHOHrqpBfnxqcUFicmpeakl8a4BBmYWZoYmpo6GxkQoAQB78Bxa</recordid><startdate>19951213</startdate><enddate>19951213</enddate><creator>GOTTHAMMAR, KRISTINA, BRIGITTA</creator><creator>LUTHMAN, PER, JOHAN</creator><creator>BJOERK, SUSANNA, KARIN, MARIA</creator><creator>PERSSON, KERSTIN, MARGARETA, IRMA</creator><creator>LINDERBERG, MAT, TORBJOERN</creator><creator>SCHWARCZ, ROBERT</creator><creator>CARPENTIER, BARRY, K</creator><scope>EVB</scope></search><sort><creationdate>19951213</creationdate><title>NEW COMPOUNDS</title><author>GOTTHAMMAR, KRISTINA, BRIGITTA ; LUTHMAN, PER, JOHAN ; BJOERK, SUSANNA, KARIN, MARIA ; PERSSON, KERSTIN, MARGARETA, IRMA ; LINDERBERG, MAT, TORBJOERN ; SCHWARCZ, ROBERT ; CARPENTIER, BARRY, K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_EP0686145A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre ; ger</language><creationdate>1995</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>GOTTHAMMAR, KRISTINA, BRIGITTA</creatorcontrib><creatorcontrib>LUTHMAN, PER, JOHAN</creatorcontrib><creatorcontrib>BJOERK, SUSANNA, KARIN, MARIA</creatorcontrib><creatorcontrib>PERSSON, KERSTIN, MARGARETA, IRMA</creatorcontrib><creatorcontrib>LINDERBERG, MAT, TORBJOERN</creatorcontrib><creatorcontrib>SCHWARCZ, ROBERT</creatorcontrib><creatorcontrib>CARPENTIER, BARRY, K</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>GOTTHAMMAR, KRISTINA, BRIGITTA</au><au>LUTHMAN, PER, JOHAN</au><au>BJOERK, SUSANNA, KARIN, MARIA</au><au>PERSSON, KERSTIN, MARGARETA, IRMA</au><au>LINDERBERG, MAT, TORBJOERN</au><au>SCHWARCZ, ROBERT</au><au>CARPENTIER, BARRY, K</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>NEW COMPOUNDS</title><date>1995-12-13</date><risdate>1995</risdate><abstract>The present invention relates to novel derivatives of 3-hydroxyanthranilic acid, 3-HANA, of the general formula I I wherein R1 and R2 are the same or different and selected from H, alkyl, aryl and arylalkyl; X and Y are the same or different and selected from alkoxy, aryloxy, alkyl, alkylthio, arylthio, fluoroalkyl, halogen, cyano, OSO2CH3, OSO2CF3, OCF3 and SCF3 with the proviso that the compound of formula I wherein R1 and R2=H, X=Br and Y=Me is excluded; or a pharmaceutically acceptable salt thereof, methods and intermediates for their preparation, novel pharmaceutical compositions and the use thereof for inhibiting the enzyme 3-hydroxyanthranilate oxygenase, 3-HAO, responsible for the production of the endogenous neurotoxin quinolinic acid, QUIN.</abstract><edition>6</edition><oa>free_for_read</oa></addata></record> |
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| language | eng ; fre ; ger |
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| subjects | ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | NEW COMPOUNDS |
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