Analogs of 15-deoxyspergualine, process for their preparation and their use as immunosuppressive agents

15-deoxy-spergualin analogues of formula (I) and their addn. salts are new. X = (CH2)n; Y = (CH2)4; T = (CH2)2; A = a single bond, -CH2-, -CH2O-, -CH2NH-, -CH(OH)-, -CHF-, or -CH(OCH3)-; n = 6-8. Intermediate cpds. of formula (II) are also claimed. A has the values above or in addn. is CH(OCH2C6H5);...

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Hauptverfasser:	DUTARTRE, PATRICK, SAMRETH, SOTH, LEBRETON, LUC, RENAUT, PATRICE, DERREPAS, PHILIPPE
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HAND TOOLS HUMAN NECESSITIES HYGIENE MANIPULATORS MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PERFORMING OPERATIONS PORTABLE POWER-DRIVEN TOOLS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS TOOLS OR BENCH DEVICES NOT OTHERWISE PROVIDED FOR, FORFASTENING, CONNECTING, DISENGAGING OR HOLDING TRANSPORTING
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creator	DUTARTRE, PATRICK SAMRETH, SOTH LEBRETON, LUC RENAUT, PATRICE DERREPAS, PHILIPPE
description	15-deoxy-spergualin analogues of formula (I) and their addn. salts are new. X = (CH2)n; Y = (CH2)4; T = (CH2)2; A = a single bond, -CH2-, -CH2O-, -CH2NH-, -CH(OH)-, -CHF-, or -CH(OCH3)-; n = 6-8. Intermediate cpds. of formula (II) are also claimed. A has the values above or in addn. is CH(OCH2C6H5); R1, R2, R3 = amino-protective gps. of alkoxycarbonyl, benzyloxycarbonyl or benzyl type.
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X = (CH2)n; Y = (CH2)4; T = (CH2)2; A = a single bond, -CH2-, -CH2O-, -CH2NH-, -CH(OH)-, -CHF-, or -CH(OCH3)-; n = 6-8. Intermediate cpds. of formula (II) are also claimed. 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X = (CH2)n; Y = (CH2)4; T = (CH2)2; A = a single bond, -CH2-, -CH2O-, -CH2NH-, -CH(OH)-, -CHF-, or -CH(OCH3)-; n = 6-8. Intermediate cpds. of formula (II) are also claimed. A has the values above or in addn. is CH(OCH2C6H5); R1, R2, R3 = amino-protective gps. of alkoxycarbonyl, benzyloxycarbonyl or benzyl type.</abstract><edition>6</edition><oa>free_for_read</oa></addata></record>
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subjects	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HAND TOOLS HUMAN NECESSITIES HYGIENE MANIPULATORS MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PERFORMING OPERATIONS PORTABLE POWER-DRIVEN TOOLS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS TOOLS OR BENCH DEVICES NOT OTHERWISE PROVIDED FOR, FORFASTENING, CONNECTING, DISENGAGING OR HOLDING TRANSPORTING
title	Analogs of 15-deoxyspergualine, process for their preparation and their use as immunosuppressive agents
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