CLONING AND EXPRESSION OF HUMANIZED MONOCLONAL ANTIBODIES AGAINST HUMAN INTERLEUKIN-4
L'invention concerne des anticorps monoclonaux spécifiques de l'interleukine-4 humaine. L'invention concerne aussi des ADN complémentaires qui codent les régions variables à chaînes légères et lourdes desdits anticorps et les régions déterminantes de complémentarité de ces ADN. Enfin...
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| creator | DALIE, BARBARA MILLER, KENNETH MURGOLO, NICHOLAS, J PEARCE, MICHAEL TINDALL, STEPHEN ZAVODNY, PAUL, J NGUYEN, HANH ABRAMS, JOHN, S LE, HUNG, V |
| description | L'invention concerne des anticorps monoclonaux spécifiques de l'interleukine-4 humaine. L'invention concerne aussi des ADN complémentaires qui codent les régions variables à chaînes légères et lourdes desdits anticorps et les régions déterminantes de complémentarité de ces ADN. Enfin l'invention concerne les nécessaires et procédés permettant de détecter, mesurer et immuno-purifier l'interleukin-4 humaine, ainsi que de bloquer l'activité biologique de cette interleukine-4.
PCT No. PCT/US93/01301 Sec. 371 Date Aug. 16, 1994 Sec. 102(e) Date Aug. 16, 1994 PCT Filed Feb. 18, 1993 PCT Pub. No. WO93/17106 PCT Pub. Date Sep. 2, 1993Monoclonal antibodies are provided which are specific for human interleukin-4. Also provided are complementary DNAs which encode the heavy and light chain variable regions of such monoclonal antibodies and complementarity determining regions from such DNAs; and kits and methods for detecting, measuring and immunopurifying human interleukin-4, and for blocking the biological activity of human interleukin-4. |
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PCT No. PCT/US93/01301 Sec. 371 Date Aug. 16, 1994 Sec. 102(e) Date Aug. 16, 1994 PCT Filed Feb. 18, 1993 PCT Pub. No. WO93/17106 PCT Pub. Date Sep. 2, 1993Monoclonal antibodies are provided which are specific for human interleukin-4. Also provided are complementary DNAs which encode the heavy and light chain variable regions of such monoclonal antibodies and complementarity determining regions from such DNAs; and kits and methods for detecting, measuring and immunopurifying human interleukin-4, and for blocking the biological activity of human interleukin-4.</description><edition>5</edition><language>eng ; fre ; ger</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; ORGANIC CHEMISTRY ; PEPTIDES ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PROCESSES USING MICROORGANISMS ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>1994</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19941207&DB=EPODOC&CC=EP&NR=0627002A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25543,76293</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19941207&DB=EPODOC&CC=EP&NR=0627002A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>DALIE, BARBARA</creatorcontrib><creatorcontrib>MILLER, KENNETH</creatorcontrib><creatorcontrib>MURGOLO, NICHOLAS, J</creatorcontrib><creatorcontrib>PEARCE, MICHAEL</creatorcontrib><creatorcontrib>TINDALL, STEPHEN</creatorcontrib><creatorcontrib>ZAVODNY, PAUL, J</creatorcontrib><creatorcontrib>NGUYEN, HANH</creatorcontrib><creatorcontrib>ABRAMS, JOHN, S</creatorcontrib><creatorcontrib>LE, HUNG, V</creatorcontrib><title>CLONING AND EXPRESSION OF HUMANIZED MONOCLONAL ANTIBODIES AGAINST HUMAN INTERLEUKIN-4</title><description>L'invention concerne des anticorps monoclonaux spécifiques de l'interleukine-4 humaine. L'invention concerne aussi des ADN complémentaires qui codent les régions variables à chaînes légères et lourdes desdits anticorps et les régions déterminantes de complémentarité de ces ADN. Enfin l'invention concerne les nécessaires et procédés permettant de détecter, mesurer et immuno-purifier l'interleukin-4 humaine, ainsi que de bloquer l'activité biologique de cette interleukine-4.
PCT No. PCT/US93/01301 Sec. 371 Date Aug. 16, 1994 Sec. 102(e) Date Aug. 16, 1994 PCT Filed Feb. 18, 1993 PCT Pub. No. WO93/17106 PCT Pub. Date Sep. 2, 1993Monoclonal antibodies are provided which are specific for human interleukin-4. Also provided are complementary DNAs which encode the heavy and light chain variable regions of such monoclonal antibodies and complementarity determining regions from such DNAs; and kits and methods for detecting, measuring and immunopurifying human interleukin-4, and for blocking the biological activity of human interleukin-4.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>PROCESSES USING MICROORGANISMS</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1994</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNyrEKwjAQANAsDqL-w_1AIVbROTbX9jC9K00C4lKKxEm0UP8fFf0Ap7e8uYqFEyauwLAFPLUdek_CICXUsTFMZ7TQCMvnGfdugQ5iCT2YyhD78H1AHLBzGI_E2XapZtfhNqXVz4WCEkNRZ2l89Gkah0u6p2ePrd7le61zs978UV4P7zAM</recordid><startdate>19941207</startdate><enddate>19941207</enddate><creator>DALIE, BARBARA</creator><creator>MILLER, KENNETH</creator><creator>MURGOLO, NICHOLAS, J</creator><creator>PEARCE, MICHAEL</creator><creator>TINDALL, STEPHEN</creator><creator>ZAVODNY, PAUL, J</creator><creator>NGUYEN, HANH</creator><creator>ABRAMS, JOHN, S</creator><creator>LE, HUNG, V</creator><scope>EVB</scope></search><sort><creationdate>19941207</creationdate><title>CLONING AND EXPRESSION OF HUMANIZED MONOCLONAL ANTIBODIES AGAINST HUMAN INTERLEUKIN-4</title><author>DALIE, BARBARA ; MILLER, KENNETH ; MURGOLO, NICHOLAS, J ; PEARCE, MICHAEL ; TINDALL, STEPHEN ; ZAVODNY, PAUL, J ; NGUYEN, HANH ; ABRAMS, JOHN, S ; LE, HUNG, V</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_EP0627002A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre ; ger</language><creationdate>1994</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>PROCESSES USING MICROORGANISMS</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><topic>SPIRITS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>DALIE, BARBARA</creatorcontrib><creatorcontrib>MILLER, KENNETH</creatorcontrib><creatorcontrib>MURGOLO, NICHOLAS, J</creatorcontrib><creatorcontrib>PEARCE, MICHAEL</creatorcontrib><creatorcontrib>TINDALL, STEPHEN</creatorcontrib><creatorcontrib>ZAVODNY, PAUL, J</creatorcontrib><creatorcontrib>NGUYEN, HANH</creatorcontrib><creatorcontrib>ABRAMS, JOHN, S</creatorcontrib><creatorcontrib>LE, HUNG, V</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>DALIE, BARBARA</au><au>MILLER, KENNETH</au><au>MURGOLO, NICHOLAS, J</au><au>PEARCE, MICHAEL</au><au>TINDALL, STEPHEN</au><au>ZAVODNY, PAUL, J</au><au>NGUYEN, HANH</au><au>ABRAMS, JOHN, S</au><au>LE, HUNG, V</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>CLONING AND EXPRESSION OF HUMANIZED MONOCLONAL ANTIBODIES AGAINST HUMAN INTERLEUKIN-4</title><date>1994-12-07</date><risdate>1994</risdate><abstract>L'invention concerne des anticorps monoclonaux spécifiques de l'interleukine-4 humaine. L'invention concerne aussi des ADN complémentaires qui codent les régions variables à chaînes légères et lourdes desdits anticorps et les régions déterminantes de complémentarité de ces ADN. Enfin l'invention concerne les nécessaires et procédés permettant de détecter, mesurer et immuno-purifier l'interleukin-4 humaine, ainsi que de bloquer l'activité biologique de cette interleukine-4.
PCT No. PCT/US93/01301 Sec. 371 Date Aug. 16, 1994 Sec. 102(e) Date Aug. 16, 1994 PCT Filed Feb. 18, 1993 PCT Pub. No. WO93/17106 PCT Pub. Date Sep. 2, 1993Monoclonal antibodies are provided which are specific for human interleukin-4. Also provided are complementary DNAs which encode the heavy and light chain variable regions of such monoclonal antibodies and complementarity determining regions from such DNAs; and kits and methods for detecting, measuring and immunopurifying human interleukin-4, and for blocking the biological activity of human interleukin-4.</abstract><edition>5</edition><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES USING MICROORGANISMS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE |
| title | CLONING AND EXPRESSION OF HUMANIZED MONOCLONAL ANTIBODIES AGAINST HUMAN INTERLEUKIN-4 |
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