2-SUBSTITUTED-4,6-DI-TERTIARY-BUTYL-5-HYDROXY-1,3-PYRIMIDINES USEFUL AS ANTIINFLAMMATORY AGENTS
L'invention concerne les nouveaux composés pyrimidines-1,3, hydroxy-5, dibutyle-4,6 tertiaire substituées en position 2 ainsi que leurs sels d'addition ou de base d'acides pharmaceutiquement acceptables, des compositions pharmaceutiques les contenant ainsi que leurs procédés d'ut...
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| creator | CONNOR, DAVID, THOMAS KOSTLAN, CATHERINE, ROSE |
| description | L'invention concerne les nouveaux composés pyrimidines-1,3, hydroxy-5, dibutyle-4,6 tertiaire substituées en position 2 ainsi que leurs sels d'addition ou de base d'acides pharmaceutiquement acceptables, des compositions pharmaceutiques les contenant ainsi que leurs procédés d'utilisation. On a découvert que lesdits composés ont une activité d'inhibiteurs de 5-lipoxygénase et/ou cyclo-oxygénase permettant le traitement d'états que l'on peut améliorer par ladite inhibition, parmi lesquels l'inflammation, l'arthrite, les douleurs, la fièvre et analogues. Ainsi, l'invention constitue également une composition pharmaceutique ou un procédé de production d'une composition pharmaceutique destinée à être utilisée dans le traitement des états précités.
PCT No. PCT/US92/00443 Sec. 371 Date Jul. 1, 1993 Sec. 102(e) Date Jul. 1, 1993 PCT Filed Jan. 17, 1992 PCT Pub. No. WO92/13536 PCT Pub. Date Aug. 20, 1992.The present invention is novel compounds which are 2-substituted-4,6-di-tertiarybutyl-5-hydroxy-1,3-pyrimidines and pharmaceutically acceptable acid addition or base salts thereof, pharmaceutical compositions and methods of use therefor. The invention compounds are now found to have activity as inhibitors of 5-lipoxygenase and/or cyclooxygenase providing treatment of conditions advantageously affected by such inhibition including inflammation, arthritis, pain, fever and the like. Thus, the present invention is also a pharmaceutical composition or method of manufacturing a pharmaceutical composition for the use of treating the noted conditions. |
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PCT No. PCT/US92/00443 Sec. 371 Date Jul. 1, 1993 Sec. 102(e) Date Jul. 1, 1993 PCT Filed Jan. 17, 1992 PCT Pub. No. WO92/13536 PCT Pub. Date Aug. 20, 1992.The present invention is novel compounds which are 2-substituted-4,6-di-tertiarybutyl-5-hydroxy-1,3-pyrimidines and pharmaceutically acceptable acid addition or base salts thereof, pharmaceutical compositions and methods of use therefor. The invention compounds are now found to have activity as inhibitors of 5-lipoxygenase and/or cyclooxygenase providing treatment of conditions advantageously affected by such inhibition including inflammation, arthritis, pain, fever and the like. Thus, the present invention is also a pharmaceutical composition or method of manufacturing a pharmaceutical composition for the use of treating the noted conditions.</description><edition>5</edition><language>eng ; fre ; ger</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>1993</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19931118&DB=EPODOC&CC=EP&NR=0569491A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25563,76318</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19931118&DB=EPODOC&CC=EP&NR=0569491A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>CONNOR, DAVID, THOMAS</creatorcontrib><creatorcontrib>KOSTLAN, CATHERINE, ROSE</creatorcontrib><title>2-SUBSTITUTED-4,6-DI-TERTIARY-BUTYL-5-HYDROXY-1,3-PYRIMIDINES USEFUL AS ANTIINFLAMMATORY AGENTS</title><description>L'invention concerne les nouveaux composés pyrimidines-1,3, hydroxy-5, dibutyle-4,6 tertiaire substituées en position 2 ainsi que leurs sels d'addition ou de base d'acides pharmaceutiquement acceptables, des compositions pharmaceutiques les contenant ainsi que leurs procédés d'utilisation. On a découvert que lesdits composés ont une activité d'inhibiteurs de 5-lipoxygénase et/ou cyclo-oxygénase permettant le traitement d'états que l'on peut améliorer par ladite inhibition, parmi lesquels l'inflammation, l'arthrite, les douleurs, la fièvre et analogues. Ainsi, l'invention constitue également une composition pharmaceutique ou un procédé de production d'une composition pharmaceutique destinée à être utilisée dans le traitement des états précités.
PCT No. PCT/US92/00443 Sec. 371 Date Jul. 1, 1993 Sec. 102(e) Date Jul. 1, 1993 PCT Filed Jan. 17, 1992 PCT Pub. No. WO92/13536 PCT Pub. Date Aug. 20, 1992.The present invention is novel compounds which are 2-substituted-4,6-di-tertiarybutyl-5-hydroxy-1,3-pyrimidines and pharmaceutically acceptable acid addition or base salts thereof, pharmaceutical compositions and methods of use therefor. The invention compounds are now found to have activity as inhibitors of 5-lipoxygenase and/or cyclooxygenase providing treatment of conditions advantageously affected by such inhibition including inflammation, arthritis, pain, fever and the like. Thus, the present invention is also a pharmaceutical composition or method of manufacturing a pharmaceutical composition for the use of treating the noted conditions.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1993</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNysEKgkAQAFAvHaL6h_0ABzJN8Di2Yw7oKruz0J5EYjtFCfb_dOkDOr3L2ybTCZyvnbB4IQ1FWoJmELLCaAPUXkIHZ2iDtsMtQJbmMAbLPWs25JR31PhOoVNohNk0HfY9ymCDwisZcftk85ifazz83CWqIbm0EJf3FNdlvsdX_Ew0Hs9lVVQZZvkf5Qvw_zLy</recordid><startdate>19931118</startdate><enddate>19931118</enddate><creator>CONNOR, DAVID, THOMAS</creator><creator>KOSTLAN, CATHERINE, ROSE</creator><scope>EVB</scope></search><sort><creationdate>19931118</creationdate><title>2-SUBSTITUTED-4,6-DI-TERTIARY-BUTYL-5-HYDROXY-1,3-PYRIMIDINES USEFUL AS ANTIINFLAMMATORY AGENTS</title><author>CONNOR, DAVID, THOMAS ; KOSTLAN, CATHERINE, ROSE</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_EP0569491A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre ; ger</language><creationdate>1993</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>CONNOR, DAVID, THOMAS</creatorcontrib><creatorcontrib>KOSTLAN, CATHERINE, ROSE</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>CONNOR, DAVID, THOMAS</au><au>KOSTLAN, CATHERINE, ROSE</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>2-SUBSTITUTED-4,6-DI-TERTIARY-BUTYL-5-HYDROXY-1,3-PYRIMIDINES USEFUL AS ANTIINFLAMMATORY AGENTS</title><date>1993-11-18</date><risdate>1993</risdate><abstract>L'invention concerne les nouveaux composés pyrimidines-1,3, hydroxy-5, dibutyle-4,6 tertiaire substituées en position 2 ainsi que leurs sels d'addition ou de base d'acides pharmaceutiquement acceptables, des compositions pharmaceutiques les contenant ainsi que leurs procédés d'utilisation. On a découvert que lesdits composés ont une activité d'inhibiteurs de 5-lipoxygénase et/ou cyclo-oxygénase permettant le traitement d'états que l'on peut améliorer par ladite inhibition, parmi lesquels l'inflammation, l'arthrite, les douleurs, la fièvre et analogues. Ainsi, l'invention constitue également une composition pharmaceutique ou un procédé de production d'une composition pharmaceutique destinée à être utilisée dans le traitement des états précités.
PCT No. PCT/US92/00443 Sec. 371 Date Jul. 1, 1993 Sec. 102(e) Date Jul. 1, 1993 PCT Filed Jan. 17, 1992 PCT Pub. No. WO92/13536 PCT Pub. Date Aug. 20, 1992.The present invention is novel compounds which are 2-substituted-4,6-di-tertiarybutyl-5-hydroxy-1,3-pyrimidines and pharmaceutically acceptable acid addition or base salts thereof, pharmaceutical compositions and methods of use therefor. The invention compounds are now found to have activity as inhibitors of 5-lipoxygenase and/or cyclooxygenase providing treatment of conditions advantageously affected by such inhibition including inflammation, arthritis, pain, fever and the like. Thus, the present invention is also a pharmaceutical composition or method of manufacturing a pharmaceutical composition for the use of treating the noted conditions.</abstract><edition>5</edition><oa>free_for_read</oa></addata></record> |
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| language | eng ; fre ; ger |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | 2-SUBSTITUTED-4,6-DI-TERTIARY-BUTYL-5-HYDROXY-1,3-PYRIMIDINES USEFUL AS ANTIINFLAMMATORY AGENTS |
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