METHODS FOR THE DIAGNOSIS OF CHRONIC LOWER BACK AND CERVICAL PAIN

L'invention se rapporte à des procédés de diagnostic et de contrôle pour les douleurs lombaires et cervicales de type chronique, qui consistent à soumettre un échantillon de fluide corporel d'un patient supposé souffrir de douleurs cervicales ou du bas du dos du type chronique à une électr...

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Hauptverfasser: CAMERON, BRUCE, M., SR, CREED, GUY, JOSEPH, VANDERPUTTEN, DALE, MERRIL, CARL, R
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creator CAMERON, BRUCE, M., SR
CREED, GUY, JOSEPH
VANDERPUTTEN, DALE
MERRIL, CARL, R
description L'invention se rapporte à des procédés de diagnostic et de contrôle pour les douleurs lombaires et cervicales de type chronique, qui consistent à soumettre un échantillon de fluide corporel d'un patient supposé souffrir de douleurs cervicales ou du bas du dos du type chronique à une électrophorèse bidimensionnelle ou à une immunoanalyse, puis à mesurer les quantités relatives de protéine(s) dont la concentration augmente ou diminue par rapport à un témoin standard. L'invention décrit également des kits à utiliser avec ces procédés de diagnostic. Methods of diagnosing peripheral nerve damage, including diagnosing and monitoring chronic back and cervical pain are disclosed. The methods involve subjecting a body fluid sample from a patient suspected of having chronic lumbar or cervical pain and peripheral nerve damage to two-dimensional electrophoresis or an immunoassay and measuring relative amounts of protein or proteins which increase or decrease in concentration as compared to a standard control. A preferred method employs an Apo-E variant as a marker of peripheral nerve damage. Also disclosed are kits for use with the diagnostic methods.
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L'invention décrit également des kits à utiliser avec ces procédés de diagnostic. Methods of diagnosing peripheral nerve damage, including diagnosing and monitoring chronic back and cervical pain are disclosed. The methods involve subjecting a body fluid sample from a patient suspected of having chronic lumbar or cervical pain and peripheral nerve damage to two-dimensional electrophoresis or an immunoassay and measuring relative amounts of protein or proteins which increase or decrease in concentration as compared to a standard control. A preferred method employs an Apo-E variant as a marker of peripheral nerve damage. 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L'invention décrit également des kits à utiliser avec ces procédés de diagnostic. Methods of diagnosing peripheral nerve damage, including diagnosing and monitoring chronic back and cervical pain are disclosed. The methods involve subjecting a body fluid sample from a patient suspected of having chronic lumbar or cervical pain and peripheral nerve damage to two-dimensional electrophoresis or an immunoassay and measuring relative amounts of protein or proteins which increase or decrease in concentration as compared to a standard control. A preferred method employs an Apo-E variant as a marker of peripheral nerve damage. Also disclosed are kits for use with the diagnostic methods.</abstract><oa>free_for_read</oa></addata></record>
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language eng ; fre ; ger
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subjects BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE
HUMAN NECESSITIES
HYGIENE
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PEPTIDES
PHYSICS
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROCESSES USING MICROORGANISMS
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
TESTING
VINEGAR
WINE
title METHODS FOR THE DIAGNOSIS OF CHRONIC LOWER BACK AND CERVICAL PAIN
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