Diazabicyclo derivatives as 5-HT3 antagonists
Diazabicyclo derivatives of formula (I) and pharmaceutically acceptable salts thereof: wherein R is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, alkoxyalkyl, oxoalkyl, alkoxycarbonylalkyl, alkoxycarbonyl, acyl, dialkylaminoalkyl, hydroxyalkyl, haloalkyl, cyanoalkyl, heterocycloalk...
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| creator | HAYAKAWA, TORU ARAI, TAKEO SUZUKI, MASASHI KIKUCHI, HARUHIKO MINO, SETSUKO FUKUTOMI, RUTA HAGIHARA, KOICHIRO SATOH, HIROAKI YAMADA, KAZUHIKO |
| description | Diazabicyclo derivatives of formula (I) and pharmaceutically acceptable salts thereof: wherein R is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, alkoxyalkyl, oxoalkyl, alkoxycarbonylalkyl, alkoxycarbonyl, acyl, dialkylaminoalkyl, hydroxyalkyl, haloalkyl, cyanoalkyl, heterocycloalkyl, aryl, heteroarylalkyl or arylalkyl, the aryl group and the aryl moiety being optionally substituted by alkoxy, nitro, alkyl, amino or halo; R is hydrogen or alkyl; R and R may be the same or different and each is hydrogen, alkyl, alkenyl, acyl, alkoxyalkyl or arylalkyl wherein the aryl moiety is optionally substituted by alkoxy, nitro, alkyl, amino or halo; with the proviso that when R is hydrogen and both R and R are methyl, R does not represent hydrogen, alkyl, unsubstituted benzyl or dimethylaminoethyl; having 5-HT3 receptor antagonist activity. |
| format | Patent |
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R is hydrogen or alkyl; R and R may be the same or different and each is hydrogen, alkyl, alkenyl, acyl, alkoxyalkyl or arylalkyl wherein the aryl moiety is optionally substituted by alkoxy, nitro, alkyl, amino or halo; with the proviso that when R is hydrogen and both R and R are methyl, R does not represent hydrogen, alkyl, unsubstituted benzyl or dimethylaminoethyl; having 5-HT3 receptor antagonist activity.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2000</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZNB1yUysSkzKTK5MzslXSEktyixLLMksSy1WSCxWMNX1CDFWSMwrSUzPz8ssLinmYWBNS8wpTuWF0twMCm6uIc4euqkF-fGpxQWJyal5qSXxrgEGpqYWlkbGTobGRCgBAExAKWI</recordid><startdate>20000524</startdate><enddate>20000524</enddate><creator>HAYAKAWA, TORU</creator><creator>ARAI, TAKEO</creator><creator>SUZUKI, MASASHI</creator><creator>KIKUCHI, HARUHIKO</creator><creator>MINO, SETSUKO</creator><creator>FUKUTOMI, RUTA</creator><creator>HAGIHARA, KOICHIRO</creator><creator>SATOH, HIROAKI</creator><creator>YAMADA, KAZUHIKO</creator><scope>EVB</scope></search><sort><creationdate>20000524</creationdate><title>Diazabicyclo derivatives as 5-HT3 antagonists</title><author>HAYAKAWA, TORU ; 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R is hydrogen or alkyl; R and R may be the same or different and each is hydrogen, alkyl, alkenyl, acyl, alkoxyalkyl or arylalkyl wherein the aryl moiety is optionally substituted by alkoxy, nitro, alkyl, amino or halo; with the proviso that when R is hydrogen and both R and R are methyl, R does not represent hydrogen, alkyl, unsubstituted benzyl or dimethylaminoethyl; having 5-HT3 receptor antagonist activity.</abstract><edition>7</edition><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY |
| title | Diazabicyclo derivatives as 5-HT3 antagonists |
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