Heterocyclic compounds
Compounds of the formula (I): or a pharmaceutically acceptable salt or ester thereof, wherein X , is nitrogen or a group CH and X is nitrogen or a group CR wherein R is hydrogen, hydroxy, halo or a group NHR wherein R is hydrogen or a C1-4 alkyl or C1-4 alkylcarbonyl group, R is amino or hydrogen; R...
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| creator | KELLEY, JAMES LEROY MCLEAN, ED WILLIAMS |
| description | Compounds of the formula (I): or a pharmaceutically acceptable salt or ester thereof, wherein X , is nitrogen or a group CH and X is nitrogen or a group CR wherein R is hydrogen, hydroxy, halo or a group NHR wherein R is hydrogen or a C1-4 alkyl or C1-4 alkylcarbonyl group, R is amino or hydrogen; R is hydrogen, halo, SH, a group NHR wherein R is hydrogen or a C1-4 alkyl or C1-4 alkylcarbonyl group or R is a group OR wherein R is hydrogen, C1-4 alkyl or benzyl, R and R are the same or different and each is hydrogen or halo, X is a chain containing m CH2 groups and n oxygen atoms, m being 1, 2, 3, 4, or 5 and n being 0, 1 or 2 the sum of m and n being 2, 3, 4, 5, or 6; are disclosed as inhibitors of the enzyme, purine nucleoside phosphorylase, pharmaceutical compositions containing the compounds, their use in medicine and processes for their preparation are also described. |
| format | Patent |
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R is hydrogen, halo, SH, a group NHR wherein R is hydrogen or a C1-4 alkyl or C1-4 alkylcarbonyl group or R is a group OR wherein R is hydrogen, C1-4 alkyl or benzyl, R and R are the same or different and each is hydrogen or halo, X is a chain containing m CH2 groups and n oxygen atoms, m being 1, 2, 3, 4, or 5 and n being 0, 1 or 2 the sum of m and n being 2, 3, 4, 5, or 6; are disclosed as inhibitors of the enzyme, purine nucleoside phosphorylase, pharmaceutical compositions containing the compounds, their use in medicine and processes for their preparation are also described.</description><language>eng ; fre ; ger</language><subject>ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM ; CHEMISTRY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>1992</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19920401&DB=EPODOC&CC=EP&NR=0478292A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19920401&DB=EPODOC&CC=EP&NR=0478292A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>KELLEY, JAMES LEROY</creatorcontrib><creatorcontrib>MCLEAN, ED WILLIAMS</creatorcontrib><title>Heterocyclic compounds</title><description>Compounds of the formula (I): or a pharmaceutically acceptable salt or ester thereof, wherein X , is nitrogen or a group CH and X is nitrogen or a group CR wherein R is hydrogen, hydroxy, halo or a group NHR wherein R is hydrogen or a C1-4 alkyl or C1-4 alkylcarbonyl group, R is amino or hydrogen; R is hydrogen, halo, SH, a group NHR wherein R is hydrogen or a C1-4 alkyl or C1-4 alkylcarbonyl group or R is a group OR wherein R is hydrogen, C1-4 alkyl or benzyl, R and R are the same or different and each is hydrogen or halo, X is a chain containing m CH2 groups and n oxygen atoms, m being 1, 2, 3, 4, or 5 and n being 0, 1 or 2 the sum of m and n being 2, 3, 4, 5, or 6; are disclosed as inhibitors of the enzyme, purine nucleoside phosphorylase, pharmaceutical compositions containing the compounds, their use in medicine and processes for their preparation are also described.</description><subject>ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM</subject><subject>CHEMISTRY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1992</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZBDzSC1JLcpPrkzOyUxWSM7PLcgvzUsp5mFgTUvMKU7lhdLcDApuriHOHrqpBfnxqcUFicmpeakl8a4BBibmFkaWRo6GxkQoAQCANCF7</recordid><startdate>19920401</startdate><enddate>19920401</enddate><creator>KELLEY, JAMES LEROY</creator><creator>MCLEAN, ED WILLIAMS</creator><scope>EVB</scope></search><sort><creationdate>19920401</creationdate><title>Heterocyclic compounds</title><author>KELLEY, JAMES LEROY ; MCLEAN, ED WILLIAMS</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_EP0478292A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre ; ger</language><creationdate>1992</creationdate><topic>ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM</topic><topic>CHEMISTRY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>KELLEY, JAMES LEROY</creatorcontrib><creatorcontrib>MCLEAN, ED WILLIAMS</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>KELLEY, JAMES LEROY</au><au>MCLEAN, ED WILLIAMS</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Heterocyclic compounds</title><date>1992-04-01</date><risdate>1992</risdate><abstract>Compounds of the formula (I): or a pharmaceutically acceptable salt or ester thereof, wherein X , is nitrogen or a group CH and X is nitrogen or a group CR wherein R is hydrogen, hydroxy, halo or a group NHR wherein R is hydrogen or a C1-4 alkyl or C1-4 alkylcarbonyl group, R is amino or hydrogen; R is hydrogen, halo, SH, a group NHR wherein R is hydrogen or a C1-4 alkyl or C1-4 alkylcarbonyl group or R is a group OR wherein R is hydrogen, C1-4 alkyl or benzyl, R and R are the same or different and each is hydrogen or halo, X is a chain containing m CH2 groups and n oxygen atoms, m being 1, 2, 3, 4, or 5 and n being 0, 1 or 2 the sum of m and n being 2, 3, 4, 5, or 6; are disclosed as inhibitors of the enzyme, purine nucleoside phosphorylase, pharmaceutical compositions containing the compounds, their use in medicine and processes for their preparation are also described.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Heterocyclic compounds |
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