REVERSED PHASE CHROMATOGRAPHIC PROCESS
An improved process for the reversed phase chromatographic decolorization, separation, and purification of water-soluble, nonionic contrast media compounds from solutions containing nonionic compound impurities involves the steps of (a) packing a chromatographic column with a chromatographic packing...
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| creator | DORAN, NARCISCO, O LIN, YOULIN DUNN, THOMAS, J WHITE, DAVID, H WONG, DAVID, MING-LEE KNELLER, MILLS, T |
| description | An improved process for the reversed phase chromatographic decolorization, separation, and purification of water-soluble, nonionic contrast media compounds from solutions containing nonionic compound impurities involves the steps of (a) packing a chromatographic column with a chromatographic packing material; (b) passing through the column a solution containing a water-soluble, nonionic contrast media compound and nonionic compounds as impurities at a loading ratio between approximately 10 to 1 and 1.5 to 1 wt. packing material/total wt. nonionic compounds; and (c) eluting the column to produce an eluate containing substantially pure, water-soluble, nonionic contrast media compound or MRI agent. The process can be economically practiced on a factory scale and efficiently removes non-polar impurities difficult to remove by conventional methods. |
| format | Patent |
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The process can be economically practiced on a factory scale and efficiently removes non-polar impurities difficult to remove by conventional methods.</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>CHEMISTRY</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PERFORMING OPERATIONS</subject><subject>PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL</subject><subject>SEPARATION</subject><subject>TRANSPORTING</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1992</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZFALcg1zDQp2dVEI8HAMdlVw9gjy93UM8XcPcgzw8HRWCAjyd3YNDuZhYE1LzClO5YXS3AwKbq4hzh66qQX58anFBYnJqXmpJfGuAQYm5gZGJuaOJsZEKAEAkaQjVg</recordid><startdate>19920708</startdate><enddate>19920708</enddate><creator>DORAN, NARCISCO, O</creator><creator>LIN, YOULIN</creator><creator>DUNN, THOMAS, J</creator><creator>WHITE, DAVID, H</creator><creator>WONG, DAVID, MING-LEE</creator><creator>KNELLER, MILLS, T</creator><scope>EVB</scope></search><sort><creationdate>19920708</creationdate><title>REVERSED PHASE CHROMATOGRAPHIC PROCESS</title><author>DORAN, NARCISCO, O ; LIN, YOULIN ; DUNN, THOMAS, J ; WHITE, DAVID, H ; WONG, DAVID, MING-LEE ; KNELLER, MILLS, T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_EP0470247A43</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>1992</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>CHEMISTRY</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PERFORMING OPERATIONS</topic><topic>PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL</topic><topic>SEPARATION</topic><topic>TRANSPORTING</topic><toplevel>online_resources</toplevel><creatorcontrib>DORAN, NARCISCO, O</creatorcontrib><creatorcontrib>LIN, YOULIN</creatorcontrib><creatorcontrib>DUNN, THOMAS, J</creatorcontrib><creatorcontrib>WHITE, DAVID, H</creatorcontrib><creatorcontrib>WONG, DAVID, MING-LEE</creatorcontrib><creatorcontrib>KNELLER, MILLS, T</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>DORAN, NARCISCO, O</au><au>LIN, YOULIN</au><au>DUNN, THOMAS, J</au><au>WHITE, DAVID, H</au><au>WONG, DAVID, MING-LEE</au><au>KNELLER, MILLS, T</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>REVERSED PHASE CHROMATOGRAPHIC PROCESS</title><date>1992-07-08</date><risdate>1992</risdate><abstract>An improved process for the reversed phase chromatographic decolorization, separation, and purification of water-soluble, nonionic contrast media compounds from solutions containing nonionic compound impurities involves the steps of (a) packing a chromatographic column with a chromatographic packing material; (b) passing through the column a solution containing a water-soluble, nonionic contrast media compound and nonionic compounds as impurities at a loading ratio between approximately 10 to 1 and 1.5 to 1 wt. packing material/total wt. nonionic compounds; and (c) eluting the column to produce an eluate containing substantially pure, water-soluble, nonionic contrast media compound or MRI agent. The process can be economically practiced on a factory scale and efficiently removes non-polar impurities difficult to remove by conventional methods.</abstract><edition>5</edition><oa>free_for_read</oa></addata></record> |
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| subjects | ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY METALLURGY ORGANIC CHEMISTRY PERFORMING OPERATIONS PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL SEPARATION TRANSPORTING |
| title | REVERSED PHASE CHROMATOGRAPHIC PROCESS |
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