VARIANTS OF PAI-2
Des variantes de l'inhibiteur de l'activateur de plasminogène-2 (PAI-2), dans lesquelles on a altéré la région résiduelle des acides aminés 66-98 de façon à éliminer au moins un site sensible à la protéase, maintiennent l'activité biologique du PAI-2 et des acides aminés 1-65 et à par...
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| creator | RICHARDSON, MICHAEL, ANDREW GOSS, NEIL, HOWARD |
| description | Des variantes de l'inhibiteur de l'activateur de plasminogène-2 (PAI-2), dans lesquelles on a altéré la région résiduelle des acides aminés 66-98 de façon à éliminer au moins un site sensible à la protéase, maintiennent l'activité biologique du PAI-2 et des acides aminés 1-65 et à partir de 99 du PAI-2 dans le cadre. L'invention concerne également les variantes décrites du PAI-2 sous forme marquée, des molécules d'ADN de codage de ces variantes, des cellules hôtes transformées qui expriment ces variantes, ces compositions et des kits de diagnostic comprenant ces variantes, des anticorps contre ces variantes et des procédés de production de ces variantes, de molécules d'ADN, d'hôtes transformés, des compositions et des anticorps décrits.
PCT No. PCT/AU90/00603 Sec. 371 Date Oct. 11, 1991 Sec. 102(e) Date Oct. 11, 1991 PCT Filed Dec. 20, 1990 PCT Pub. No. WO91/09124 PCT Pub. Date Jun. 27, 1991.Variants of the plasminogen activator inhibitor PAI-2 in which the 66-98 amino acid residue region has been altered to eliminate at least one protease sensitive site are provided. The variants of the invention maintain the biological activity of PAI-2 and amino acids up to 65 and from 99 of PAI-2 in frame. The PAI-2 variants of the invention in labelled form, as well as DNA molecules encoding the variants of the invention, transformed host cells expressing the variants of the invention compositions and diagnostic kits comprising the variants of the invention, antibodies against the variants of the invention and processes for the production of the variants, DNA molecules, transformed hosts, compositions and antibodies of the invention are also described. |
| format | Patent |
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PCT No. PCT/AU90/00603 Sec. 371 Date Oct. 11, 1991 Sec. 102(e) Date Oct. 11, 1991 PCT Filed Dec. 20, 1990 PCT Pub. No. WO91/09124 PCT Pub. Date Jun. 27, 1991.Variants of the plasminogen activator inhibitor PAI-2 in which the 66-98 amino acid residue region has been altered to eliminate at least one protease sensitive site are provided. The variants of the invention maintain the biological activity of PAI-2 and amino acids up to 65 and from 99 of PAI-2 in frame. The PAI-2 variants of the invention in labelled form, as well as DNA molecules encoding the variants of the invention, transformed host cells expressing the variants of the invention compositions and diagnostic kits comprising the variants of the invention, antibodies against the variants of the invention and processes for the production of the variants, DNA molecules, transformed hosts, compositions and antibodies of the invention are also described.</description><language>eng ; fre ; ger</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE ; HUMAN NECESSITIES ; HYGIENE ; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES ; MEASURING ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; ORGANIC CHEMISTRY ; PEPTIDES ; PHYSICS ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PROCESSES USING MICROORGANISMS ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; SPIRITS ; TESTING ; VINEGAR ; WINE</subject><creationdate>1991</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19911204&DB=EPODOC&CC=EP&NR=0458937A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25543,76294</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19911204&DB=EPODOC&CC=EP&NR=0458937A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>RICHARDSON, MICHAEL, ANDREW</creatorcontrib><creatorcontrib>GOSS, NEIL, HOWARD</creatorcontrib><title>VARIANTS OF PAI-2</title><description>Des variantes de l'inhibiteur de l'activateur de plasminogène-2 (PAI-2), dans lesquelles on a altéré la région résiduelle des acides aminés 66-98 de façon à éliminer au moins un site sensible à la protéase, maintiennent l'activité biologique du PAI-2 et des acides aminés 1-65 et à partir de 99 du PAI-2 dans le cadre. L'invention concerne également les variantes décrites du PAI-2 sous forme marquée, des molécules d'ADN de codage de ces variantes, des cellules hôtes transformées qui expriment ces variantes, ces compositions et des kits de diagnostic comprenant ces variantes, des anticorps contre ces variantes et des procédés de production de ces variantes, de molécules d'ADN, d'hôtes transformés, des compositions et des anticorps décrits.
PCT No. PCT/AU90/00603 Sec. 371 Date Oct. 11, 1991 Sec. 102(e) Date Oct. 11, 1991 PCT Filed Dec. 20, 1990 PCT Pub. No. WO91/09124 PCT Pub. Date Jun. 27, 1991.Variants of the plasminogen activator inhibitor PAI-2 in which the 66-98 amino acid residue region has been altered to eliminate at least one protease sensitive site are provided. The variants of the invention maintain the biological activity of PAI-2 and amino acids up to 65 and from 99 of PAI-2 in frame. The PAI-2 variants of the invention in labelled form, as well as DNA molecules encoding the variants of the invention, transformed host cells expressing the variants of the invention compositions and diagnostic kits comprising the variants of the invention, antibodies against the variants of the invention and processes for the production of the variants, DNA molecules, transformed hosts, compositions and antibodies of the invention are also described.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</subject><subject>MEASURING</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PHYSICS</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>PROCESSES USING MICROORGANISMS</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>SPIRITS</subject><subject>TESTING</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1991</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZBAMcwzydPQLCVbwd1MIcPTUNeJhYE1LzClO5YXS3AwKbq4hzh66qQX58anFBYnJqXmpJfGuAQYmphaWxuaOhsZEKAEAzGEdHg</recordid><startdate>19911204</startdate><enddate>19911204</enddate><creator>RICHARDSON, MICHAEL, ANDREW</creator><creator>GOSS, NEIL, HOWARD</creator><scope>EVB</scope></search><sort><creationdate>19911204</creationdate><title>VARIANTS OF PAI-2</title><author>RICHARDSON, MICHAEL, ANDREW ; GOSS, NEIL, HOWARD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_EP0458937A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre ; ger</language><creationdate>1991</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</topic><topic>MEASURING</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PHYSICS</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>PROCESSES USING MICROORGANISMS</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><topic>SPIRITS</topic><topic>TESTING</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>RICHARDSON, MICHAEL, ANDREW</creatorcontrib><creatorcontrib>GOSS, NEIL, HOWARD</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>RICHARDSON, MICHAEL, ANDREW</au><au>GOSS, NEIL, HOWARD</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>VARIANTS OF PAI-2</title><date>1991-12-04</date><risdate>1991</risdate><abstract>Des variantes de l'inhibiteur de l'activateur de plasminogène-2 (PAI-2), dans lesquelles on a altéré la région résiduelle des acides aminés 66-98 de façon à éliminer au moins un site sensible à la protéase, maintiennent l'activité biologique du PAI-2 et des acides aminés 1-65 et à partir de 99 du PAI-2 dans le cadre. L'invention concerne également les variantes décrites du PAI-2 sous forme marquée, des molécules d'ADN de codage de ces variantes, des cellules hôtes transformées qui expriment ces variantes, ces compositions et des kits de diagnostic comprenant ces variantes, des anticorps contre ces variantes et des procédés de production de ces variantes, de molécules d'ADN, d'hôtes transformés, des compositions et des anticorps décrits.
PCT No. PCT/AU90/00603 Sec. 371 Date Oct. 11, 1991 Sec. 102(e) Date Oct. 11, 1991 PCT Filed Dec. 20, 1990 PCT Pub. No. WO91/09124 PCT Pub. Date Jun. 27, 1991.Variants of the plasminogen activator inhibitor PAI-2 in which the 66-98 amino acid residue region has been altered to eliminate at least one protease sensitive site are provided. The variants of the invention maintain the biological activity of PAI-2 and amino acids up to 65 and from 99 of PAI-2 in frame. The PAI-2 variants of the invention in labelled form, as well as DNA molecules encoding the variants of the invention, transformed host cells expressing the variants of the invention compositions and diagnostic kits comprising the variants of the invention, antibodies against the variants of the invention and processes for the production of the variants, DNA molecules, transformed hosts, compositions and antibodies of the invention are also described.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES USING MICROORGANISMS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TESTING VINEGAR WINE |
| title | VARIANTS OF PAI-2 |
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