NOVEL CEPHALOSPORIN INTERMEDIATES AND PROCESS FOR PREPARING THE INTERMEDIATES AND THEIR END PRODUCTS

The present invention provides certain novel cephalosporin derivatives represented by following formula(I), which are especially useful as intermediates for the preparation of cephalosporin compounds possessed with potent and broad antibacterial activities. wherein: R is a C1-4alkyl, C3-4 alkenyl, C...

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Hauptverfasser: KIM, YONG ZU, KIM, WON SUP, BANG, CHAN SIK, YEO, JAE HONG, LIM, JONG CHAN
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creator KIM, YONG ZU
KIM, WON SUP
BANG, CHAN SIK
YEO, JAE HONG
LIM, JONG CHAN
description The present invention provides certain novel cephalosporin derivatives represented by following formula(I), which are especially useful as intermediates for the preparation of cephalosporin compounds possessed with potent and broad antibacterial activities. wherein: R is a C1-4alkyl, C3-4 alkenyl, C3-4 cycloalkyl, amino optionally substititued with a C1-4 alkyl radical, or phenyl group optionally subsitututed on its 2-, 4-and/or 6-position with a halogen, C1-4 alkyl, C1-3 alkoxy or hydroxy radical; R is hydrogen or a C1-4 alkyl group; and n is either 0 or 1. The invention also relates to processes for preparing these intermediates and their pharmacologically active cephalosporin antibiotics.
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title NOVEL CEPHALOSPORIN INTERMEDIATES AND PROCESS FOR PREPARING THE INTERMEDIATES AND THEIR END PRODUCTS
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