Lyophilized dihydrochloride of 7-[alpha-(2-aminothiazol-4-yl)-alpha-(Z)-methoxyiminoacetamido]-3-[(1-methyl-1-pyrrolidinium)-methyl]-3-cephem-4-carboxylate

Lyophilized dihydrochloride of 7-[alpha-(2-aminothiazol-4-yl)-alpha-(Z)-methoxyiminoacetamido]-3-[(1-methyl-1-pyrrolidinium)-methyl]-3-cephem-4-carboxylate

A stable, amorphous, lyophilized dihydrochloride salt of 7-( alpha -(2-aminothiazol-4-yl)- alpha -(Z)-methoxyiminoacetamido]-3-[(1-methyl-1-pyrrolidi nium)methyl]-3-cephem-4-carboxylate is described. This lyophilized salt is more easily prepared than the crystalline counterpart and can be reconstitu...

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Hauptverfasser: KAPLAN, MURRAY A, NASSAR, MUNIR N
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Sprache:eng ; fre ; ger
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CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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creator KAPLAN, MURRAY A
NASSAR, MUNIR N
description A stable, amorphous, lyophilized dihydrochloride salt of 7-( alpha -(2-aminothiazol-4-yl)- alpha -(Z)-methoxyiminoacetamido]-3-[(1-methyl-1-pyrrolidi nium)methyl]-3-cephem-4-carboxylate is described. This lyophilized salt is more easily prepared than the crystalline counterpart and can be reconstituted in effective concentrations for intramuscular and intravenous injection utilizing suitable organic and inorganic bases to pH 3-7.0.
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title Lyophilized dihydrochloride of 7-[alpha-(2-aminothiazol-4-yl)-alpha-(Z)-methoxyiminoacetamido]-3-[(1-methyl-1-pyrrolidinium)-methyl]-3-cephem-4-carboxylate
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