5'-Phosphonates of 3'-azido-2',3'-dideoxynucleosides

L'invention se rapporte à la biologie moléculaire. Les substances 5'-phosphonates 3'-azido-2',3'-didésoxynucléosides ont la formule générale (I), où R = (a), (b), (c), où B est thimine-1-yl, cytosine-1-yl, adénine-9-yl, guanine-9-yl. Ces substances sont des inhibiteurs sélec...

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Hauptverfasser:	TARUSOVA, NATALYA BORISOVNA, KHORLIN, ALEXANDR ANATOLIEVICH, KRAEVSKY, ALEXANDR ANTONOVICH, DYATKINA, NATALYA BORISOVNA, KORNEEVA, MARINA NIKOLAEVNA, NOSIK, DMITRY NIKOLAEVICH, MAIOROVA, SVETLANA NIKOLAEVNA, SHOBUKHOV, VADIM MAXIMOVICH, BIBILASHVILI, ROBERT SHALVOVICH, GALEGOV, GEORGY ARTEMIEVICH, ZHDANOV, VIKTOR MIKHAILOVICH
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	CHEMISTRY DERIVATIVES THEREOF HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SUGARS
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Beschreibung
Zusammenfassung:	L'invention se rapporte à la biologie moléculaire. Les substances 5'-phosphonates 3'-azido-2',3'-didésoxynucléosides ont la formule générale (I), où R = (a), (b), (c), où B est thimine-1-yl, cytosine-1-yl, adénine-9-yl, guanine-9-yl. Ces substances sont des inhibiteurs sélectifs de la reproduction du virus d'immunodéficience humaine dans la culture des lymphocytes humains. PCT No. PCT/SU88/00271 Sec. 371 Date Aug. 18, 1989 Sec. 102(e) Date Aug. 18, 1989 PCT Filed Dec. 20, 1988 PCT Pub. No. WO89/06238 PCT Pub. Date Jul. 13, 1989.The compounds of the invention are 5'-phosphonates of 3'-azido-2',3'-dideoxynucleosides having the following general formula: where B is thymin-1-yl, cytosin-1-yl, adenin-9-yl, or guanin-9-yl. The compounds according to the present invention are selective inhibitors of replication of the human immunodeficiency virus in a culture of human lymphocytes.