Benzodiazepine derivatives

A compound of the formula : wherein R is halogen, heterocyclic group which may have one or more suitable substituent(s), aryl which may have one or more suitable substituent(s), -NH-R (in which R is hydrogen, lower alkanoyl or hydroxy(lower)alkyl), -S-R (in which R is lower alkyl, lower alkyl substituted with carboxy and amino, lower alkyl substituted with protected carboxy and protected amino, or pyridyl), -O-R (in which R is hydrogen, hydroxy protective group, lower alkyl, lower alkenyl, ar(lower)alkyl, halo(lower)alkyl, amino(loweralkyl, protected amino(lower)alkyl, or piperazinyl(lower)alkyl which may have lower alkyl), -CONH-R (in which R is cyano, carbamoyl(lower)alkyl, carboxy(lower)alkyl, protected carboxy(lower)alkyl, or lower alkyl substituted with carbamoyl and aryl ), or -Z-R [in which R is hydrogen or lower alkyl, and Z is (wherein is hydroxy, lower alkoxy or amino) or (wherein R is carboxy or protected carboxy and R is hydrogen; or R is halogen and R is halogen)], R is aryl which may have one or more suitable substituent(s), R is hydrogen or halogen, R is hydrogen, halogen or lower alkoxy and A is lower alkylene, and a pharmaceutically acceptable salt thereof, processes for the preparation and pharmaceutical compositions comprising them as an active ingredient