RECOMBINANT ANTIBODY

Molécule d'anticorps modifié (AAM), dotée d'une région charnière comportant un nombre de résidus de cystéine différent de celui trouvé dans la région charnière normalement associée au domaine CH1 de la molécule d'anticorps, et procédé en permettant la production par une technologie re...

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Hauptverfasser:	BODMER, MARK, WILLIAM, WHITTLE, NIGEL, RICHARD, ADAIR, JOHN, ROBERT
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES USING MICROORGANISMS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS TESTING VINEGAR WINE
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creator	BODMER, MARK, WILLIAM WHITTLE, NIGEL, RICHARD ADAIR, JOHN, ROBERT
description	Molécule d'anticorps modifié (AAM), dotée d'une région charnière comportant un nombre de résidus de cystéine différent de celui trouvé dans la région charnière normalement associée au domaine CH1 de la molécule d'anticorps, et procédé en permettant la production par une technologie recombinante à base d'ADN. PCT No. PCT/GB88/00729 Sec. 371 Date Jul. 3, 1989 Sec. 102(e) Date Jul. 3, 1989 PCT Filed Sep. 5, 1988 PCT Pub. No. WO89/01782 PCT Pub. Date Mar. 9, 1989.The present invention provides an altered antibody molecule wherein a residue in a surface pocket on the molecule has been changed to a cysteine residue to introduce a thiol group in the surface pocket and a process for its production by recombinant DNA technology.
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PCT No. PCT/GB88/00729 Sec. 371 Date Jul. 3, 1989 Sec. 102(e) Date Jul. 3, 1989 PCT Filed Sep. 5, 1988 PCT Pub. No. WO89/01782 PCT Pub. 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PCT No. PCT/GB88/00729 Sec. 371 Date Jul. 3, 1989 Sec. 102(e) Date Jul. 3, 1989 PCT Filed Sep. 5, 1988 PCT Pub. No. WO89/01782 PCT Pub. 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subjects	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES USING MICROORGANISMS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS TESTING VINEGAR WINE
title	RECOMBINANT ANTIBODY
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